Negative regulation of MAPK pathway

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
inactive RAFsPAQR3:inactive RAFsPaqr3Pebp1p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1p21RAS:GTP:activated RAF1 homo/heterodimerp21RAS:GTP:dephosphorylated RAF1 homo/heterodimerPiH2Op21RAS:GTP:p-S621 RAF1 homo/heterodimerp-T,Y MAPK monomers and dimersMAPK monomers and dimersPip-T,Y MAPK monomers and dimersMAPK monomers and dimersBRAPBRAP:KSR1:MARK3KSR1:MARK3p21 RAS:GTPp21 RAS:GTP:BRAPUbp21 RAS:GTP:ub-BRAPp-ERK dimerPTPN7:p-T,Y-MAPK dimersPTPN7PTPN7:p-T-MAPK dimersO08911PTPN3:p-T183,Y185-MAPK12PTPN3MAPK12ATPADPp-S459 PTPN3:p-T183,Y185-MAPK12
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025