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Connector enhancer of kinase suppressor of ras 2
Summary
- UniProt ID
- Q8WXI2
- Gene Symbol
-
- CNKSR2
- CNK2
- KIAA0902
- KSR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Coiled coil
- Cytoplasm
- Disease variant
- Intellectual disability
- Membrane
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| postsynapse organization |
| regulation of signal transduction |
| intracellular signal transduction |
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| neuronal cell body |
| extrinsic component of postsynaptic density membrane |
| extracellular exosome |
| glutamatergic synapse |
| GO Term |
|---|
| protein kinase binding |
| identical protein binding |
Sequence
MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 332 |
|
|
||
| 898 |
|
|||
| 900 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| MAP2K and MAPK activation | Homo sapiens |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | Homo sapiens |
| Signaling by BRAF and RAF1 fusions | Homo sapiens |
| Signaling by RAF1 mutants | Homo sapiens |
| Signaling by high-kinase activity BRAF mutants | Homo sapiens |
| Signaling by moderate kinase activity BRAF mutants | Homo sapiens |
| Signaling downstream of RAS mutants | Homo sapiens |
