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Beta-klotho
Summary
- UniProt ID
- Q99N32
- Gene Symbol
-
- Betakl
- Klb
- Gene ID
- 83379
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0007258
- PubChem
- Q99N32
- Re-Glyco
- Q99N32
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Glycoprotein
- Reference proteome
- Repeat
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| membrane |
| GO Term |
|---|
| hydrolase activity, hydrolyzing O-glycosyl compounds |
| fibroblast growth factor binding |
| fibroblast growth factor receptor binding |
Sequence
MKTGCAAGSPGNEWIFFSSDERNTRSRKTMSNRALQRSAVLSAFVLLRAVTGFSGDGKAIWDKKQYVSPVNPSQLFLYDTFPKNFSWGVGTGAFQVEGSWKTDGRGPSIWDRYVYSHLRGVNGTDRSTDSYIFLEKDLLALDFLGVSFYQFSISWPRLFPNGTVAAVNAQGLRYYRALLDSLVLRNIEPIVTLYHWDLPLTLQEEYGGWKNATMIDLFNDYATYCFQTFGDRVKYWITIHNPYLVAWHGFGTGMHAPGEKGNLTAVYTVGHNLIKAHSKVWHNYDKNFRPHQKGWLSITLGSHWIEPNRTDNMEDVINCQHSMSSVLGWFANPIHGDGDYPEFMKTGAMIPEFSEAEKEEVRGTADFFAFSFGPNNFRPSNTVVKMGQNVSLNLRQVLNWIKLEYDDPQILISENGWFTDSYIKTEDTTAIYMMKNFLNQVLQAIKFDEIRVFGYTAWTLLDGFEWQDAYTTRRGLFYVDFNSEQKERKPKSSAHYYKQIIQDNGFPLKESTPDMKGRFPCDFSWGVTESVLKPEFTVSSPQFTDPHLYVWNVTGNRLLYRVEGVRLKTRPSQCTDYVSIKKRVEMLAKMKVTHYQFALDWTSILPTGNLSKVNRQVLRYYRCVVSEGLKLGVFPMVTLYHPTHSHLGLPLPLLSSGGWLNMNTAKAFQDYAELCFRELGDLVKLWITINEPNRLSDMYNRTSNDTYRAAHNLMIAHAQVWHLYDRQYRPVQHGAVSLSLHCDWAEPANPFVDSHWKAAERFLQFEIAWFADPLFKTGDYPSVMKEYIASKNQRGLSSSVLPRFTAKESRLVKGTVDFYALNHFTTRFVIHKQLNTNRSVADRDVQFLQDITRLSSPSRLAVTPWGVRKLLAWIRRNYRDRDIYITANGIDDLALEDDQIRKYYLEKYVQEALKAYLIDKVKIKGYYAFKLTEEKSKPRFGFFTSDFRAKSSVQFYSKLISSSGLPAENRSPACGQPAEDTDCTICSFLVEKKPLIFFGCCFISTLAVLLSITVFHHQKRRKFQKARNLQNIPLKKGHSRVFS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 84 | N-linked (GlcNAc...) asparagine |
|
||
| 122 | N-linked (GlcNAc...) asparagine |
|
||
| 161 | N-linked (GlcNAc...) asparagine |
|
||
| 211 | N-linked (GlcNAc...) asparagine |
|
||
| 262 | N-linked (GlcNAc...) asparagine |
|
||
| 308 | N-linked (GlcNAc...) asparagine |
|
||
| 389 | N-linked (GlcNAc...) asparagine |
|
||
| 552 | N-linked (GlcNAc...) asparagine |
|
||
| 609 | N-linked (GlcNAc...) asparagine |
|
||
| 700 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| FRS-mediated FGFR4 signaling | Mus musculus |
| Negative regulation of FGFR4 signaling | Mus musculus |
| PI-3K cascade:FGFR4 | Mus musculus |
| PI3K Cascade | Mus musculus |
| PI3K/AKT Signaling | Mus musculus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Mus musculus |
| Phospholipase C-mediated cascade; FGFR4 | Mus musculus |
| RAF/MAP kinase cascade | Mus musculus |
| SHC-mediated cascade:FGFR4 | Mus musculus |
| betaKlotho-mediated ligand binding | Mus musculus |
