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MIRAGE
Toll-like receptor 9

Summary
UniProt ID
Q9NR96
Gene Symbol
  • TLR9
  • UNQ5798/PRO19605
Gene ID
54106
Organism
Homo sapiens (human)
GlyGen
Q9NR96
PubChem
Q9NR96
The Human Metabolome Database
HMDBP02761
Re-Glyco
Q9NR96
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cytoplasmic vesicle
  • Disulfide bond
  • Endoplasmic reticulum
  • Endosome
  • Glycoprotein
  • Golgi apparatus
  • Inflammatory response
  • Innate immunity
  • Leucine-rich repeat
  • Lysosome
  • Palmitate
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying entries 1 - 10 of 15 in total
GO Term
extracellular region
cytoplasm
lysosome
plasma membrane
Golgi membrane
endosome
endoplasmic reticulum
endoplasmic reticulum membrane
basolateral plasma membrane
apical plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 14 in total
Position Description PubMed ID GlyTouCan ID Source
64 N-linked (GlcNAc...) asparagine
129 N-linked (GlcNAc...) asparagine
200 N-linked (GlcNAc...) asparagine
209
210 N-linked (GlcNAc...) asparagine
242 N-linked (GlcNAc...) asparagine
300 N-linked (GlcNAc...) asparagine
340 N-linked (GlcNAc...) asparagine
469 N-linked (GlcNAc...) asparagine
474 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 7 entries
Pathway Name Organism
MyD88 dependent cascade initiated on endosome Homo sapiens
PI3K Cascade Homo sapiens
Potential therapeutics for SARS Homo sapiens
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Homo sapiens
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Homo sapiens
Toll Like Receptor 9 (TLR9) Cascade Homo sapiens
Trafficking and processing of endosomal TLR Homo sapiens
Disease
Displaying entries 1 - 10 of 15 in total
DO ID Disease Name Source
DOID:0080162 lupus nephritis
DOID:10533 viral pneumonia
DOID:1287 cardiovascular system disease
DOID:13166 allergic bronchopulmonary aspergillosis
DOID:1485 cystic fibrosis
DOID:1883 hepatitis C
DOID:2043 hepatitis B
DOID:2799 bronchiolitis obliterans
DOID:2841 asthma
DOID:2957 pulmonary tuberculosis
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025