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MIRAGE
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

Summary
UniProt ID
Q9NST1
Gene Symbol
  • ADPN
  • C22orf20
  • PNPLA3
Gene ID
80339
Organism
Homo sapiens (human)
GlyGen
Q9NST1
PubChem
Q9NST1
SwissLipids
The Human Metabolome Database
HMDBP00232
Re-Glyco
Q9NST1
Annotation
Keyword
  • Acyltransferase
  • Alternative splicing
  • Disease variant
  • Glycoprotein
  • Hydrolase
  • Lipid droplet
  • Obesity
  • Phospholipid biosynthesis
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 4 entries
GO Term
cytoplasm
membrane
endoplasmic reticulum membrane
lipid droplet
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGIPLEQTLQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISLTRVSDGENVLVSDFRSKDEVVDALVCSCFIPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICPKVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDELLDHLRLSILPWDESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTLPVESAIAIVQRLVTWLPDMPDDVLWLQWVTSQVFTRVLMCLLPASRSQMPVSSQQASPCTPEQDWPCWTPCSPKGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGLSTFPSFSLEKSL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 2 entries
Position Description PubMed ID GlyTouCan ID Source
89 N-linked (GlcNAc...) asparagine
280 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying 1 entry
Pathway Name Organism
Acyl chain remodeling of DAG and TAG Homo sapiens
Disease
Displaying all 6 entries
DO ID Disease Name Source
DOID:0080208 metabolic dysfunction-associated steatotic liver disease
DOID:3393 coronary artery disease
DOID:5082 liver cirrhosis
DOID:684 hepatocellular carcinoma
DOID:9352 type 2 diabetes mellitus
DOID:9452 steatotic liver disease
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025