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Repository for lectin-assisted multimodality data
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Toll-like receptor 7
Summary
- UniProt ID
- Q9NYK1
- Gene Symbol
-
- TLR7
- UNQ248/PRO285
- Gene ID
- 51284
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cytoplasmic vesicle
- Disease variant
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Inflammatory response
- Innate immunity
- Leucine-rich repeat
- Lysosome
- Receptor
- Reference proteome
- Repeat
- Signal
- Systemic lupus erythematosus
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| endolysosome membrane |
| GO Term |
|---|
| pattern recognition receptor activity |
| double-stranded RNA binding |
| single-stranded RNA binding |
| siRNA binding |
Sequence
MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 66 | N-linked (GlcNAc...) asparagine |
|
||
| 69 | N-linked (GlcNAc...) asparagine |
|
||
| 167 | N-linked (GlcNAc...) asparagine |
|
||
| 202 | N-linked (GlcNAc...) asparagine | |||
| 215 | N-linked (GlcNAc...) asparagine |
|
||
| 361 | N-linked (GlcNAc...) asparagine |
|
||
| 413 | N-linked (GlcNAc...) asparagine |
|
||
| 488 | N-linked (GlcNAc...) asparagine |
|
||
| 523 | N-linked (GlcNAc...) asparagine |
|
||
| 534 | N-linked (GlcNAc...) asparagine |
|
G57776ZS
G45395BF
G63041LO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective regulation of TLR7 by endogenous ligand | Homo sapiens |
| MyD88 dependent cascade initiated on endosome | Homo sapiens |
| Potential therapeutics for SARS | Homo sapiens |
| RSV-host interactions | Homo sapiens |
| Regulation of TLR by endogenous ligand | Homo sapiens |
| SARS-CoV-1 activates/modulates innate immune responses | Homo sapiens |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | Homo sapiens |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | Homo sapiens |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | Homo sapiens |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080600 | COVID-19 | |
| DOID:0112063 | X-Linked immunodeficiency 74 |
