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Toll-like receptor 4

Summary

UniProt ID

Q9QUK6

Gene Symbol

Tlr4
Lps

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0007644
GlyGen: Q9QUK6
PubChem: Q9QUK6

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Disease variant
Disulfide bond
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Leucine-rich repeat
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **91 - 100** of **101** in total

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GO Term
positive regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of peptidyl-tyrosine phosphorylation
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of macrophage cytokine production
response to fatty acid
positive regulation of cytokine production involved in inflammatory response
positive regulation of reactive oxygen species biosynthetic process

Displaying **all 10** entries
GO Term
plasma membrane
receptor complex
lipopolysaccharide receptor complex
ruffle
phagocytic cup
endosome membrane
early endosome
external side of plasma membrane
cell surface
perinuclear region of cytoplasm

Displaying **all 8** entries
GO Term
transmembrane signaling receptor activity
signaling receptor binding
NAD+ nucleotidase, cyclic ADP-ribose generating
identical protein binding
protein heterodimerization activity
lipopolysaccharide binding
lipopolysaccharide immune receptor activity
phosphatidylinositol 3-kinase binding

Annotation information from UniProt.

Sequence

MMPPWLLARTLIMALFFSCLTPGSLNPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 14 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
34	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
75	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
172	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
204	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
237	N-linked (GlcNAc...) asparagine	17803912	G62765YT	GlycoProtDB UniProt GlyGen
307	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
492	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
495	N-linked (GlcNAc...) asparagine			UniProt GlyGen
524	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
572	N-linked (GlcNAc...) asparagine	17803912	G50303LH	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 11 in total

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Pathway Name	Organism
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	Mus musculus
Heme signaling	Mus musculus
IKK complex recruitment mediated by RIP1	Mus musculus
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Mus musculus
Ligand-dependent caspase activation	Mus musculus
MyD88-independent TLR4 cascade	Mus musculus
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	Mus musculus
Regulation of TLR by endogenous ligand	Mus musculus
TRAF6-mediated induction of TAK1 complex within TLR4 complex	Mus musculus
TRIF-mediated programmed cell death	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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International Collaboration

Acknowledgements