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Oxysterols receptor LXR-alpha

Summary

UniProt ID

Q9Z0Y9

Gene Symbol

Nr1h3
Lxra

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q9Z0Y9
PubChem: Q9Z0Y9
The O-GlcNAc Database: Q9Z0Y9

Annotation

Keyword

3D-structure
Activator
Cytoplasm
DNA-binding
Nucleus
Phosphoprotein
Receptor
Reference proteome
Transcription regulation
Ubl conjugation
Zinc-finger

Gene Ontology (GO)

Displaying entries **1 - 10** of 34 in total

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GO Term
fatty acid biosynthetic process
negative regulation of transcription by RNA polymerase II
regulation of DNA-templated transcription
cholesterol homeostasis
negative regulation of DNA-templated transcription
positive regulation of DNA-templated transcription
positive regulation of transcription by RNA polymerase II
sterol homeostasis
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol efflux

Displaying **all 8** entries
GO Term
nucleolus
cytoplasm
receptor complex
chromatin
nucleus
cytosol
nucleoplasm
RNA polymerase II transcription regulator complex

Displaying **all 10** entries
GO Term
nuclear retinoid X receptor binding
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity
nuclear receptor activity
sequence-specific DNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
zinc ion binding
sterol response element binding
protein-containing complex binding
chromatin DNA binding

Annotation information from UniProt.

Sequence

MSLWLEASMPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGVALGIGLESAEPTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
LXRs regulate gene expression linked to cholesterol transport and efflux	Mus musculus
LXRs regulate gene expression to control bile acid homeostasis	Mus musculus
Nuclear Receptor transcription pathway	Mus musculus
SUMOylation of intracellular receptors	Mus musculus
VLDLR internalisation and degradation	Mus musculus