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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Complement factor B
Summary
- UniProt ID
- P00751
- Gene Symbol
-
- CFB
- BF
- BFD
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Alternative splicing
- Cleavage on pair of basic residues
- Complement alternate pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycation
- Hemolytic uremic syndrome
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sushi
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| proteolysis |
| complement activation |
| complement activation, alternative pathway |
| response to bacterium |
| GO Term |
|---|
| classical-complement-pathway C3/C5 convertase complex |
| blood microparticle |
| extracellular region |
| extracellular space |
| plasma membrane |
| extracellular exosome |
| GO Term |
|---|
| complement binding |
| serine-type endopeptidase activity |
Sequence
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of C3 and C5 | Homo sapiens |
| Alternative complement activation | Homo sapiens |
| Regulation of Complement cascade | Homo sapiens |
