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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Nicastrin
Summary
- UniProt ID
- P57716
- Gene Symbol
-
- Ncstn
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Cytoplasmic vesicle
- Disulfide bond
- Glycoprotein
- Notch signaling pathway
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| gamma-secretase complex |
| synaptic membrane |
| sarcolemma |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| early endosome |
| synaptic vesicle |
| presynaptic membrane |
| Golgi membrane |
| lysosome |
| GO Term |
|---|
| peptidase activity |
| growth factor receptor binding |
| ATPase binding |
| protein-macromolecule adaptor activity |
Sequence
MATTRGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLKWVLTDGPNPPYMVLLEGKLFTRDVMEKLKGTTSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSVGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLSRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLDLWMHTDPMSQKNESVKNQVEDLLATLEKSGAGVPEVVLRRLAQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPEWQSPEEDLNFVTDTAKALANVATVLARALYELAGGTNFSSSIQADPQTVTRLLYGFLVRANNSWFQSILKHDLRSYLDDRPLQHYIAVSSPTNTTYVVQYALANLTGKATNLTREQCQDPSKVPNESKDLYEYSWVQGPWNSNRTERLPQCVRSTVRLARALSPAFELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSTLVFSLIVTYCINAKADVLFVAPREPGAVSY
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| EPH-ephrin mediated repulsion of cells | Mus musculus |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | Mus musculus |
| NRIF signals cell death from the nucleus | Mus musculus |
| Neutrophil degranulation | Mus musculus |
| Noncanonical activation of NOTCH3 | Mus musculus |
| Nuclear signaling by ERBB4 | Mus musculus |
| Regulated proteolysis of p75NTR | Mus musculus |
