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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Lysosomal protective protein
Summary
- UniProt ID
- P10619
- Gene Symbol
-
- CTSA
- PPGB
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Carboxypeptidase
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Lysosome
- Reference proteome
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular exosome |
| endoplasmic reticulum |
| extracellular region |
| lysosome |
| membrane |
| intracellular membrane-bounded organelle |
| azurophil granule lumen |
| lysosomal lumen |
| GO Term |
|---|
| carboxypeptidase activity |
| serine-type carboxypeptidase activity |
| enzyme activator activity |
Sequence
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 333 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective NEU1 causes sialidosis | Homo sapiens |
| Glycosphingolipid catabolism | Homo sapiens |
| MHC class II antigen presentation | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Sialic acid metabolism | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080523 | adult-onset leukoencephalopathy with axonal spheroids and pigmented glia | |
| DOID:0080540 | galactosialidosis | |
| DOID:0111035 | CADASIL 1 | |
| DOID:0111390 | mucopolysaccharidosis Ih | |
| DOID:0111392 | mucopolysaccharidosis type IVB | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:1003 | pelvic inflammatory disease | |
| DOID:1059 | intellectual disability | |
| DOID:1074 | kidney failure | |
| DOID:10763 | hypertension |
