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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Lysosomal acid lipase/cholesteryl ester hydrolase
Summary
- UniProt ID
- P38571
- Gene Symbol
-
- LIPA
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011671
- GlyConnect
- GlyGen
- P38571
- PubChem
- P38571
- SwissLipids
- The Human Metabolome Database
- HMDBP00227
- The O-GlcNAc Database
- P38571
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Hydrolase
- Lipid degradation
- Lysosome
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| glucose metabolic process |
| fatty acid metabolic process |
| endocytosis |
| lysosome organization |
| gene expression |
| lipid catabolic process |
| glycolytic process |
| cholesterol biosynthetic process |
| ATP biosynthetic process |
| vitamin A metabolic process |
| GO Term |
|---|
| lysosome |
| intracellular membrane-bounded organelle |
| cytosol |
| fibrillar center |
| nucleoplasm |
| lysosomal lumen |
| GO Term |
|---|
| sterol esterase activity |
| lipase activity |
Sequence
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| LDL clearance | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110047 | Alzheimer's disease 14 | |
| DOID:0110048 | Alzheimer's disease 15 | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:10493 | adrenal cortical hypofunction | |
| DOID:10602 | obsolete steatorrhea | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10763 | hypertension | |
| DOID:10825 | essential hypertension | |
| DOID:114 | heart disease |
