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Transmembrane glycoprotein NMB

Summary

UniProt ID

Q14956

Gene Symbol

GPNMB
HGFIN
NMB

Organism

Homo sapiens (human)

External Links

GlyConnect

1847

GlyGen

Q14956

PubChem

Q14956

The O-GlcNAc Database

Q14956

RaftProt

Q14956

Annotation

Keyword

Alternative splicing
Amyloidosis
Cell membrane
Disease variant
Endosome
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
negative regulation of cytokine production
positive regulation of protein phosphorylation
cell adhesion
signal transduction
cell-cell signaling
negative regulation of cell population proliferation
positive regulation of cell migration
negative regulation of T cell proliferation
negative regulation of tumor necrosis factor production
regulation of tissue remodeling

Displaying **all 4** entries
GO Term
plasma membrane
membrane
melanosome membrane
early endosome membrane

Displaying **all 5** entries
GO Term
heparin binding
syndecan binding
receptor ligand activity
integrin binding
chemoattractant activity

Annotation information from UniProt.

Sequence

MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFVTMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
93	N-linked (GlcNAc...) asparagine		G14547CB G06247RL G79666IR G07246CJ G14972EH G00912UN G15664MX G29184RN G70223PD G72747WU G46503DX G80920RR G47702MW G02886BB G90659AW G64409MC G83633GK G62765YT G64527OM G47950XN G47644PP G05049YU G05724UK G31852PQ G96993FE G23719VF G41247ZX G02815KT G92050GC	UniProt GlyGen GlyConnect
134	N-linked (GlcNAc...) asparagine			UniProt GlyGen
146	N-linked (GlcNAc...) asparagine			UniProt GlyGen
200	N-linked (GlcNAc...) asparagine	19159218	G08609CW G14547CB G06247RL G44753VC G60834IK G86880BF G27947YN G20528HD G37692EO G33416PL G04854VP G94470IW G79666IR G98611JV G40834TG G45395BF G59324HL G07246CJ G10819WX G40926MX G43223CG G49642SA G58954YZ G37412TK G31986NC G26330YA G10846ZT G40574BA G78787DI G00273SJ G08918WF G00912UN G61256FT G83646BJ G17208MA G46691LC G27126ED G27058EU G43769HG G83460ZZ G37509XX G60033FS G35253PZ G72747WU G70619PT G59626AS G92406TI G20210JR G41840AI G01650EU G23294PN G70101JE G80920RR G63041LO G65184UU G02886BB G90659AW G45504EY G59924QI G12313PD G29299MO G37399XV G62765YT G47950XN G47644PP G95177YH G10486CT G05049YU G90734RJ G28541PG G18647XP G85269DF G72291OX G95865ZB G05724UK G31852PQ G90575OW G72787SB G23719VF G33609NS G39446WN G39188ZX G41247ZX G35029YA G57776ZU G36379GD G02815KT G06110VR G84349RE G57317CE G92050GC G92275SC G14669DU G28681TP	UniProt GlyGen GlyConnect
249	N-linked (GlcNAc...) asparagine	19159218	G74381CZ G66537LK G01521EA G13191RB G53075ES G76868JS G09831WQ G11115RO G67164EE G81637OR G99679NM G95046LV G32788FZ G52890YB G05962QB G45526EA G70232NH G37818NZ G69521XL G06247RL G35541EV G93718GY G80075MS G57776ZS G29545VG G44753VC G68490OW G86880BF G27947YN G90382BL G80479JV G85282JO G20528HD G87123QX G79666IR G47012YE G45395BF G40926MX G14972EH G43223CG G40574BA G75983OB G00912UN G58087IP G27915IV G70441OD G83646BJ G76295SF G46691LC G25451PN G27058EU G84452RH G83460ZZ G37509XX G60033FS G41071NU G59626AS G08290VR G25079LO G70101JE G80920RR G63041LO G01485JJ G42124LM G90659AW G45504EY G64409MC G29299MO G37399XV G62765YT G64527OM G47950XN G62894KT G11870QZ G47644PP G95177YH G10486CT G05049YU G18647XP G85269DF G72291OX G95865ZB G31852PQ G96993FE G72787SB G23719VF G11314AS G41247ZX G57776ZU G36379GD G02815KT G74724QE G92275SC G28681TP	UniProt GlyGen GlyConnect
275	N-linked (GlcNAc...) asparagine	19159218	G94310CV G52848YE G74381CZ G66537LK G01521EA G13191RB G09700PF G63040RU G53075ES G12745LE G76868JS G31309XD G94665LC G11115RO G67164EE G30221QT G81637OR G07810QS G71463BG G50856PC G99679NM G82443XX G32788FZ G56518TU G63136LV G01160VV G60967DT G05962QB G30740WO G45526EA G12341GU G70232NH G55132BD G37818NZ G69521XL G70888PK G06247RL G47518TP G12261QD G35541EV G34617SM G93718GY G13131HA G49755GI G75568BH G80075MS G57776ZS G16125XL G29545VG G44753VC G68490OW G99668VU G77669RF G60834IK G86880BF G27947YN G90382BL G80479JV G85282JO G40206WX G63980BQ G04854VP G94470IW G87123QX G79666IR G92135MA G98611JV G34989PA G40834TG G02528FI G43669FQ G45395BF G59324HL G07246CJ G85554PZ G20706XG G10819WX G40926MX G59536GA G14972EH G43223CG G58954YZ G37412TK G31986NC G26330YA G40574BA G78787DI G00273SJ G08918WF G00912UN G48414YA G49906RN G58087IP G27915IV G87389XI G23505EP G92551JA G61256FT G70441OD G87661QW G83646BJ G76295SF G27126ED G34029GR G04657PL G27058EU G70223PD G60033FS G41071NU G07755XJ G86182NS G49018RC G35253PZ G72747WU G70619PT G06356OH G59626AS G73430PD G84862VB G08290VR G46503DX G41840AI G01650EU G80920RR G01485JJ G65184UU G02886BB G90659AW G77547TA G31916IQ G45504EY G64409MC G29299MO G37399XV G62765YT G47950XN G11870QZ G47644PP G72790NZ G10486CT G05049YU G90734RJ G18647XP G85269DF G72291OX G95865ZB G72787SB G23719VF G39446WN G11314AS G29880MM G35029YA G57776ZU G06110VR G92050GC G74724QE G92275SC G14669DU G28681TP G84225JN G98129XB	UniProt GlyGen GlyConnect
296	N-linked (GlcNAc...) asparagine	19159218		UniProt GlyGen
300	N-linked (GlcNAc...) asparagine	19159218		UniProt GlyGen
306	N-linked (GlcNAc...) asparagine	19159218		UniProt GlyGen
312	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
PTK6 promotes HIF1A stabilization	Homo sapiens

Disease

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DO ID	Disease Name	Source
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050646	distal arthrogryposis	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060680	pigment dispersion syndrome	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET
DOID:0060896	Parkinson's disease 23	DisGeNET
DOID:0080001	bone disease	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET

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Acknowledgements