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CD209 antigen

Summary

Lectin Name Aliases

DC-SIGN
LSECtin CRD Fc

Monosaccharide Specificities

Organism

Homo sapiens (human)

External Links

UniProt

Q9NNX6

LfDB

UniLectin

Q9NNX6

CarboGrove

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Disulfide bond
Endocytosis
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Innate immunity
Mannose-binding
Metal-binding
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix

Gene Ontology (GO)

Displaying entries **11 - 18** of 18 in total

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GO Term
positive regulation of T cell proliferation
regulation of T cell proliferation
innate immune response
peptide antigen transport
intracellular transport of virus
virion attachment to host cell
viral entry into host cell
cell-cell recognition

Displaying **all 7** entries
GO Term
external side of plasma membrane
cell surface
extracellular region
cytoplasm
plasma membrane
membrane
host cell

Displaying **all 6** entries
GO Term
virion binding
mannose binding
carbohydrate binding
metal ion binding
virus receptor activity
peptide antigen binding

Annotation information from UniProt.

Reference

Displaying entries **1 - 10** of 52 in total

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PubMed ID	Title	First Author
11337487	Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.	Mummidi S
11384997	A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.	Mitchell DA
11799126	Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1.	Geijtenbeek TB
12122001	Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes.	Colmenares M
12496255	The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan.	Maeda N
12626400	The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x.	van Die I
12609975	DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2.	Lozach PY
12695508	Oligolysine-based oligosaccharide clusters: selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin.	Frison N
14711836	Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.	Liu W
14970226	DC-SIGN binds to HIV-1 glycoprotein 120 in a distinct but overlapping fashion compared with ICAM-2 and ICAM-3.	Su SV

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Butyrophilin (BTN) family interactions	Homo sapiens
CD209 (DC-SIGN) signaling	Homo sapiens
RSV-host interactions	Homo sapiens

UniLectin

UniProt
Q9NNX6

CarboGrove

Lectin Name: DC-SIGN
Common Name: DC-SIGN

Automated Analysis report (Top 10 high affinity glycans)

Array Source

Microbial

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G26425MP	33510	443.36
G25559RS	33029.5	724.08
G32046JJ	32195	1420.58
G48796BQ	31499	820.95
G64541AU	31369.5	388.91
G39023AU	30834.5	832.97
G26425MP	29150	908.63
G61491DK	29040.5	3225.82
G07682RX	28365	630.03
G00052MO	28117	601.75

GlyTouCan ID	Binding Intensity	Stdev
G53402KW	34798.5	67.88
G00051MO	34590	335.88
G25559RS	34211	313.25
G39023AU	33946.5	704.28
G00051MO	33050	297.69
G00052MO	32134	566.39
G32046JJ	28725.5	636.4
G26425MP	22898	1125.01
G64541AU	14759.5	435.58
G07682RX	3839.5	148.49

GlyTouCan ID	Binding Intensity	Stdev
G00052MO	24279	311.13
G53402KW	21797.5	183.14
G39023AU	17106	1197.84
G00051MO	14919.5	731.86
G25559RS	11041.5	3551.8
G00051MO	7597	16.97
G32046JJ	1947	91.92
G26425MP	344.5	68.59
G64541AU	273	15.56
G07682RX	134	14.14

GlyTouCan ID	Binding Intensity	Stdev
G53402KW	19767.5	192.33
G00051MO	19058.5	43.84
G00051MO	18948	149.2
G00052MO	18836	68.59
G39023AU	18725	116.67
G25559RS	16751.5	255.97
G32046JJ	15869.5	316.78
G26425MP	11577.5	690.14
G64541AU	11446	157.68
G07682RX	8035.5	205.06

GlyTouCan ID	Binding Intensity	Stdev
G00051MO	21324	147.79
G00052MO	21116	417.9
G53402KW	21084	188.8
G39023AU	20598.5	103.24
G00051MO	20421.5	353.55
G25559RS	15771	419.31
G32046JJ	11840.5	141.42
G26425MP	7133	205.77
G64541AU	5836	409.41
G07682RX	1725.5	206.48

GlyTouCan ID	Binding Intensity	Stdev
G00052MO	19368	1991.21
G39023AU	18401.5	830.85
G53402KW	17975	28.28
G00051MO	17670.5	1390.88
G00051MO	17308	161.22
G25559RS	14092.5	67.18
G32046JJ	6716.5	313.25
G26425MP	2475	188.09
G64541AU	1720.5	229.81
G07682RX	339	42.43

CarboGrove View

CarboGrove is populated with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies by processing and interpreting data from various types of glycan arrays.