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CD209 antigen

Summary

Lectin Name Aliases

DC-SIGN
LSECtin CRD Fc

Monosaccharide Specificities

Organism

Homo sapiens (human)

External Links

UniProt

Q9NNX6

LfDB

UniLectin

Q9NNX6

CarboGrove

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Disulfide bond
Endocytosis
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Innate immunity
Mannose-binding
Metal-binding
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 18 in total

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GO Term
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
adaptive immune response
endocytosis
immune response
leukocyte cell-cell adhesion
antigen processing and presentation
intracellular signal transduction
positive regulation of T cell proliferation
regulation of T cell proliferation
innate immune response

Displaying **all 7** entries
GO Term
external side of plasma membrane
cell surface
extracellular region
cytoplasm
plasma membrane
membrane
host cell

Displaying **all 7** entries
GO Term
mannose binding
carbohydrate binding
fucose binding
metal ion binding
virus receptor activity
peptide antigen binding
virion binding

Annotation information from UniProt.

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Butyrophilin (BTN) family interactions	Homo sapiens
CD209 (DC-SIGN) signaling	Homo sapiens
RSV-host interactions	Homo sapiens

UniLectin

UniProt	PDB
Q9NNX6	1K9I 1SL4 1SL5 2B6B 2IT5 2IT6 2XR5 2XR6 6GHV 7NL6 7NL7

CarboGrove

Lectin Name: DC-SIGN
Common Name: DC-SIGN

Automated Analysis report (Top 10 high affinity glycans)

Array Source

Microbial

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G26425MP	33510.0	443.355987548828125
G25559RS	33029.5	724.0772705078125
G32046JJ	32195.0	1420.5780029296875
G48796BQ	31499.0	820.95098876953125
G64541AU	31369.5	388.90869140625
G39023AU	30834.5	832.9718017578125
G26425MP	29150.0	908.6322021484375
G61491DK	29040.5	3225.821044921875
G07682RX	28365.0	630.0321044921875
G00052MO	28117.0	601.7479248046875

GlyTouCan ID	Binding Intensity	Stdev
G53402KW	34798.5	67.88230133056640625
G00051MO	34590.0	335.875701904296875
G25559RS	34211.0	313.248291015625
G39023AU	33946.5	704.27838134765625
G00051MO	33050.0	297.691986083984375
G00052MO	32134.0	566.39251708984375
G32046JJ	28725.5	636.3961181640625
G26425MP	22898.0	1125.0069580078125
G64541AU	14759.5	435.577789306640625
G07682RX	3839.5	148.492401123046875

GlyTouCan ID	Binding Intensity	Stdev
G00052MO	24279.0	311.12701416015625
G53402KW	21797.5	183.1407012939453125
G39023AU	17106.0	1197.8389892578125
G00051MO	14919.5	731.85552978515625
G25559RS	11041.5	3551.797119140625
G00051MO	7597.0	16.970600128173828125
G32046JJ	1947.0	91.92389678955078125
G26425MP	344.5	68.5894012451171875
G64541AU	273.0	15.556400299072265625
G07682RX	134.0	14.142100334167480469

GlyTouCan ID	Binding Intensity	Stdev
G53402KW	19767.5	192.3329925537109375
G00051MO	19058.5	43.84059906005859375
G00051MO	18948.0	149.199493408203125
G00052MO	18836.0	68.5894012451171875
G39023AU	18725.0	116.67259979248046875
G25559RS	16751.5	255.9727020263671875
G32046JJ	15869.5	316.7838134765625
G26425MP	11577.5	690.13623046875
G64541AU	11446.0	157.6847991943359375
G07682RX	8035.5	205.061004638671875

GlyTouCan ID	Binding Intensity	Stdev
G00051MO	21324.0	147.7852935791015625
G00052MO	21116.0	417.90008544921875
G53402KW	21084.0	188.7975006103515625
G39023AU	20598.5	103.23760223388671875
G00051MO	20421.5	353.55340576171875
G25559RS	15771.0	419.314300537109375
G32046JJ	11840.5	141.4214019775390625
G26425MP	7133.0	205.768096923828125
G64541AU	5836.0	409.414794921875
G07682RX	1725.5	206.4752044677734375

GlyTouCan ID	Binding Intensity	Stdev
G00052MO	19368.0	1991.2130126953125
G39023AU	18401.5	830.85052490234375
G53402KW	17975.0	28.284299850463867188
G00051MO	17670.5	1390.8790283203125
G00051MO	17308.0	161.220306396484375
G25559RS	14092.5	67.17510223388671875
G32046JJ	6716.5	313.248291015625
G26425MP	2475.0	188.09039306640625
G64541AU	1720.5	229.8096923828125
G07682RX	339.0	42.42639923095703125

CarboGrove View

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).