GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **276 - 298** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_003438	Ribose-5-phosphate isomerase	P49247		Homo sapiens (human)	9606	D-ribose metabolic process cytoplasm cytosol identical protein binding intracellular membrane-bounded organelle monosaccharide binding pentose-phosphate shunt, non-oxidative branch pentose-phosphate shunt ribose-5-phosphate isomerase activity	GO:0004751 GO:0005737 GO:0005829 GO:0006014 GO:0006098 GO:0009052 GO:0042802 GO:0043231 GO:0048029
GL_001413	Complement C4-B	P0C0L5	6YSQ	Homo sapiens (human)	9606	axon blood microparticle carbohydrate binding complement activation, classical pathway complement activation complement binding dendrite detection of molecule of bacterial origin endopeptidase inhibitor activity extracellular exosome extracellular region extracellular space inflammatory response innate immune response opsonization plasma membrane positive regulation of apoptotic cell clearance symbiont cell surface synapse	GO:0001848 GO:0004866 GO:0005576 GO:0005615 GO:0005886 GO:0006954 GO:0006956 GO:0006958 GO:0008228 GO:0030246 GO:0030424 GO:0030425 GO:0032490 GO:0045087 GO:0045202 GO:0070062 GO:0072562 GO:0106139 GO:2000427
GL_001143	Tetranectin	P05452	1HTN 1RJH 1TN3 3L9J	Homo sapiens (human)	9606	bone mineralization calcium ion binding carbohydrate binding cellular response to organic substance cellular response to transforming growth factor beta stimulus collagen-containing extracellular matrix cytoplasm extracellular exosome extracellular region extracellular space granular component heparin binding kringle domain binding ossification platelet dense granule lumen positive regulation of plasminogen activation	GO:0001503 GO:0001652 GO:0005509 GO:0005576 GO:0005615 GO:0005737 GO:0008201 GO:0010756 GO:0030246 GO:0030282 GO:0031089 GO:0036143 GO:0062023 GO:0070062 GO:0071310 GO:0071560
GL_004706	Putative inactive beta-glucuronidase-like protein SMA3	Q15486		Homo sapiens (human)	9606	beta-glucuronidase activity carbohydrate binding extracellular space glucuronoside catabolic process nervous system development signaling receptor binding skeletal system development	GO:0001501 GO:0004566 GO:0005102 GO:0005615 GO:0007399 GO:0019391 GO:0030246
GL_000358	Early activation antigen CD69	Q07108	1E87 1E8I 1FM5 3CCK 3HUP 8G94	Homo sapiens (human)	9606	carbohydrate binding cellular response to xenobiotic stimulus external side of plasma membrane identical protein binding plasma membrane protein-containing complex transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0009897 GO:0030246 GO:0032991 GO:0042802 GO:0071466
GL_001178	Zymogen granule membrane protein 16	O60844	3APA 3VY6 3VY7 3VZE 3VZF 3VZG 7O3I 7O4P 7O88	Homo sapiens (human)	9606	Golgi lumen carbohydrate binding collagen-containing extracellular matrix defense response to Gram-positive bacterium extracellular space mucus layer peptidoglycan binding protein transport suppression of symbiont entry into host zymogen granule membrane	GO:0005615 GO:0005796 GO:0015031 GO:0030246 GO:0042589 GO:0042834 GO:0050830 GO:0052373 GO:0062023 GO:0070701
GL_001231	Alpha-mannosidase 2	Q16706		Homo sapiens (human)	9606	Golgi medial cisterna Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding cis-Golgi network extracellular exosome hydrolase activity, hydrolyzing N-glycosyl compounds in utero embryonic development liver development lung alveolus development mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity membrane metal ion binding mitochondrion organization positive regulation of neurogenesis protein glycosylation protein homodimerization activity respiratory gaseous exchange by respiratory system retina morphogenesis in camera-type eye vacuole organization viral protein processing	GO:0000139 GO:0001701 GO:0001889 GO:0004559 GO:0004572 GO:0005797 GO:0005801 GO:0006013 GO:0006486 GO:0006491 GO:0007005 GO:0007033 GO:0007585 GO:0016020 GO:0016799 GO:0019082 GO:0030246 GO:0042803 GO:0046872 GO:0048286 GO:0050769 GO:0060042 GO:0070062
GL_000180	C-type lectin domain family 4 member E	Q9ULY5	3WH2 3WH3	Homo sapiens (human)	9606	Fc-gamma receptor signaling pathway T cell differentiation involved in immune response antifungal innate immune response calcium ion binding carbohydrate binding cell projection defense response to bacterium external side of plasma membrane glycolipid binding innate immune response membrane pattern recognition receptor activity pattern recognition receptor signaling pathway phagocytic cup phagocytic vesicle membrane plasma membrane positive regulation of cytokine production	GO:0001819 GO:0001891 GO:0002221 GO:0002292 GO:0005509 GO:0005886 GO:0009897 GO:0016020 GO:0030246 GO:0030670 GO:0038094 GO:0038187 GO:0042742 GO:0042995 GO:0045087 GO:0051861 GO:0061760
GL_003353	Pyruvate kinase PKLR	P30613	2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 5SC8 5SC9 5SCA 5SCB 5SCC 5SCD 5SCE 5SCF 5SCG 5SCH 5SCI 5SCJ 5SCK 5SCL 5SDT 6NN4 6NN5 6NN7 6NN8 7FRV 7FRW 7FRX 7FRY 7FRZ 7FS0 7FS1 7FS2 7FS3 7FS4 7FS5 7FS6 7FS7 7FS8 7FS9 7FSA 7FSB 7FSC 7FSD 7QDN 7QZU 8TBS 8TBT 8TBU	Homo sapiens (human)	9606	ATP binding cellular response to epinephrine stimulus cellular response to insulin stimulus cytoplasm cytosol extracellular exosome glycolytic process kinase activity magnesium ion binding monosaccharide binding phosphorylation potassium ion binding pyruvate biosynthetic process pyruvate kinase activity pyruvate kinase complex response to ATP response to cAMP response to glucose response to hypoxia response to metal ion response to nutrient	GO:0000287 GO:0001666 GO:0004743 GO:0005524 GO:0005737 GO:0005829 GO:0006096 GO:0007584 GO:0009749 GO:0010038 GO:0016301 GO:0016310 GO:0030955 GO:0032869 GO:0033198 GO:0042866 GO:0048029 GO:0051591 GO:0070062 GO:0071872 GO:1902912
GL_000914	Polypeptide N-acetylgalactosaminyltransferase 3	Q14435		Homo sapiens (human)	9606	Golgi apparatus Golgi cisterna membrane Golgi membrane O-glycan processing calcium ion binding carbohydrate binding carbohydrate metabolic process extracellular exosome fibroblast growth factor receptor signaling pathway manganese ion binding membrane perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via serine protein O-linked glycosylation via threonine protein O-linked glycosylation spermatogenesis	GO:0000139 GO:0004653 GO:0005509 GO:0005794 GO:0005975 GO:0006493 GO:0007283 GO:0008543 GO:0016020 GO:0016266 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0048471 GO:0070062
GL_003251	C-type lectin domain family 17, member A	Q6ZS10		Homo sapiens (human)	9606	cell surface external side of plasma membrane fucose binding identical protein binding mannose binding metal ion binding signaling receptor activity	GO:0005537 GO:0009897 GO:0009986 GO:0038023 GO:0042802 GO:0042806 GO:0046872
GL_000968	Protein FAM3A	P98173		Homo sapiens (human)	9606	antifungal humoral response antimicrobial humoral immune response mediated by antimicrobial peptide carbohydrate binding extracellular space negative regulation of antifungal innate immune response	GO:0005615 GO:0019732 GO:0030246 GO:0061844 GO:1905035
GL_002812	Proteoglycan 4	Q92954		Homo sapiens (human)	9606	collagen-containing extracellular matrix extracellular space immune response polysaccharide binding scavenger receptor activity	GO:0005044 GO:0005615 GO:0006955 GO:0030247 GO:0062023
GL_002069	Regenerating islet-derived protein 4	Q9BYZ8	2KV3	Homo sapiens (human)	9606	cytoplasm extracellular region heparin binding mannan binding response to bacterium signaling receptor activity	GO:0005576 GO:0005737 GO:0008201 GO:0009617 GO:0038023 GO:2001065
GL_000888	Polypeptide N-acetylgalactosaminyltransferase 10	Q86SR1	2D7I 2D7R	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_002758	HLA class II histocompatibility antigen, DRB1 beta chain	P01911	1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FYT 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2SEB 2WBJ 2XN9 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6HBY 6NIX 6QZA 6QZC 6QZD 6R0E 6V0Y 6V13 6V15 6V18 6V19 6V1A 8TBP	Homo sapiens (human)	9606	CD4 receptor binding ER to Golgi transport vesicle membrane Golgi membrane MHC class II protein complex binding MHC class II protein complex MHC class II receptor activity T cell receptor binding T cell receptor signaling pathway T-helper 1 type immune response antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II autolysosome membrane cell surface clathrin-coated endocytic vesicle membrane detection of bacterium endocytic vesicle membrane epidermis development external side of plasma membrane extracellular exosome extracellular space humoral immune response immune response immunological synapse inflammatory response to antigenic stimulus intermediate filament late endosome membrane lumenal side of endoplasmic reticulum membrane lysosomal membrane macrophage differentiation membrane myeloid dendritic cell antigen processing and presentation negative regulation of T cell proliferation negative regulation of inflammatory response to antigenic stimulus negative regulation of type II interferon production peptide antigen assembly with MHC class II protein complex peptide antigen binding plasma membrane polysaccharide binding positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade positive regulation of T cell activation positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immune response to tumor cell positive regulation of canonical NF-kappaB signal transduction positive regulation of immune response positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of kinase activity positive regulation of memory T cell differentiation positive regulation of monocyte differentiation positive regulation of protein phosphorylation positive regulation of viral entry into host cell protein tetramerization regulation of T-helper cell differentiation regulation of interleukin-10 production regulation of interleukin-4 production signal transduction structural constituent of cytoskeleton trans-Golgi network membrane transport vesicle membrane	GO:0000139 GO:0001772 GO:0001916 GO:0001934 GO:0002437 GO:0002469 GO:0002491 GO:0002503 GO:0002842 GO:0002862 GO:0005200 GO:0005615 GO:0005765 GO:0005882 GO:0005886 GO:0006955 GO:0006959 GO:0007165 GO:0008544 GO:0009897 GO:0009986 GO:0012507 GO:0016020 GO:0016045 GO:0019886 GO:0023026 GO:0030225 GO:0030247 GO:0030658 GO:0030666 GO:0030669 GO:0031902 GO:0032395 GO:0032588 GO:0032653 GO:0032673 GO:0032689 GO:0032831 GO:0033674 GO:0035774 GO:0042088 GO:0042130 GO:0042605 GO:0042608 GO:0042609 GO:0042613 GO:0043123 GO:0043382 GO:0043410 GO:0045622 GO:0045657 GO:0045893 GO:0046598 GO:0050778 GO:0050852 GO:0050870 GO:0051262 GO:0070062 GO:0070374 GO:0098553 GO:0120281 GO:2000516
GL_002325	T-cell surface antigen CD2	P06729	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	Homo sapiens (human)	9606	Golgi apparatus T cell activation apoptotic process cell surface receptor signaling pathway cell surface cell-cell adhesion cell-cell junction cytoplasmic side of plasma membrane external side of plasma membrane extracellular region heterotypic cell-cell adhesion identical protein binding membrane raft polarization natural killer cell activation natural killer cell mediated cytotoxicity nucleoplasm plasma membrane positive regulation of interleukin-8 production positive regulation of myeloid dendritic cell activation positive regulation of tumor necrosis factor production positive regulation of type II interferon production protein self-association protein-containing complex receptor tyrosine kinase binding regulation of T cell differentiation signaling receptor activity signaling receptor binding	GO:0001766 GO:0005102 GO:0005576 GO:0005654 GO:0005794 GO:0005886 GO:0005911 GO:0006915 GO:0007166 GO:0009897 GO:0009898 GO:0009986 GO:0030101 GO:0030887 GO:0030971 GO:0032729 GO:0032757 GO:0032760 GO:0032991 GO:0034113 GO:0038023 GO:0042110 GO:0042267 GO:0042802 GO:0043621 GO:0045580 GO:0098609
GL_005175	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	O60568	6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE	Homo sapiens (human)	9606	Golgi apparatus L-ascorbic acid binding basement membrane assembly collagen fibril organization collagen metabolic process collagen-containing extracellular matrix endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum endothelial cell morphogenesis epidermis morphogenesis extracellular exosome extracellular space hydroxylysine biosynthetic process in utero embryonic development iron ion binding lung morphogenesis metal ion binding neural tube development peptidyl-lysine hydroxylation procollagen galactosyltransferase activity procollagen glucosyltransferase activity procollagen-lysine 5-dioxygenase activity protein O-linked glycosylation protein localization rough endoplasmic reticulum small molecule binding trans-Golgi network vasodilation	GO:0001701 GO:0001886 GO:0005506 GO:0005615 GO:0005783 GO:0005788 GO:0005789 GO:0005791 GO:0005794 GO:0005802 GO:0006493 GO:0008104 GO:0008475 GO:0017185 GO:0021915 GO:0030199 GO:0031418 GO:0032963 GO:0033823 GO:0036094 GO:0042311 GO:0046872 GO:0046947 GO:0048730 GO:0050211 GO:0060425 GO:0062023 GO:0070062 GO:0070831
GL_000075	Attractin-like protein 1	Q5VV63		Homo sapiens (human)	9606	G protein-coupled receptor signaling pathway Golgi apparatus Notch binding carbohydrate binding membrane	GO:0005112 GO:0005794 GO:0007186 GO:0016020 GO:0030246
GL_000103	Beta/gamma crystallin domain-containing protein 2	Q8N1P7		Homo sapiens (human)	9606	carbohydrate binding lens development in camera-type eye structural constituent of eye lens visual perception	GO:0002088 GO:0005212 GO:0007601 GO:0030246
GL_000829	NKG2-E type II integral membrane protein	Q07444		Homo sapiens (human)	9606	carbohydrate binding cellular defense response external side of plasma membrane plasma membrane positive regulation of natural killer cell mediated cytotoxicity receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0004888 GO:0005886 GO:0006968 GO:0009897 GO:0030246 GO:0032814 GO:0043235 GO:0045954
GL_004526	Fructose-bisphosphate aldolase A	P04075	1ALD 2ALD 4ALD 5KY6 6XMH 6XML 6XMM 6XMO	Homo sapiens (human)	9606	ATP biosynthetic process I band M band RNA binding actin binding actin cytoskeleton actin filament organization binding of sperm to zona pellucida cadherin binding cytoskeletal protein binding cytosol extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen fructose 1,6-bisphosphate metabolic process fructose binding fructose metabolic process fructose-bisphosphate aldolase activity glycolytic process identical protein binding membrane muscle cell cellular homeostasis nucleus platelet alpha granule lumen protein homotetramerization regulation of cell shape secretory granule lumen sperm head striated muscle contraction tertiary granule lumen tubulin binding	GO:0003723 GO:0003779 GO:0004332 GO:0005576 GO:0005615 GO:0005634 GO:0005829 GO:0006000 GO:0006096 GO:0006754 GO:0006941 GO:0007015 GO:0007339 GO:0008092 GO:0008360 GO:0015629 GO:0015631 GO:0016020 GO:0030388 GO:0031093 GO:0031430 GO:0031674 GO:0034774 GO:0042802 GO:0045296 GO:0046716 GO:0051289 GO:0061827 GO:0070061 GO:0070062 GO:1904724 GO:1904813
GL_000304	Cell migration-inducing and hyaluronan-binding protein	Q8WUJ3		Homo sapiens (human)	9606	ER retention sequence binding carbohydrate binding clathrin heavy chain binding clathrin-coated endocytic vesicle clathrin-coated pit clathrin-coated vesicle membrane cytoplasm endoplasmic reticulum extracellular region fibrillar center hyaluronan biosynthetic process hyaluronan catabolic process hyaluronic acid binding hyalurononglucosaminidase activity nuclear membrane plasma membrane positive regulation of cell migration positive regulation of peptidyl-threonine phosphorylation positive regulation of protein kinase C activity positive regulation of protein targeting to membrane positive regulation of release of sequestered calcium ion into cytosol sensory perception of sound	GO:0001650 GO:0004415 GO:0005540 GO:0005576 GO:0005737 GO:0005783 GO:0005886 GO:0005905 GO:0007605 GO:0010800 GO:0030213 GO:0030214 GO:0030246 GO:0030335 GO:0030665 GO:0031965 GO:0032050 GO:0045334 GO:0046923 GO:0051281 GO:0090314 GO:1900020

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