GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **276 - 298** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	LfDB IDs	Organism ▼	Taxonomy ID	MCAW IDs	Gene Ontology	Gene Ontology ID
GL_005179	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Q02809			Homo sapiens (human)	9606		L-ascorbic acid binding catalytic complex endoplasmic reticulum membrane endoplasmic reticulum epidermis development extracellular exosome iron ion binding peptidyl-lysine hydroxylation procollagen-lysine 5-dioxygenase activity response to hypoxia rough endoplasmic reticulum membrane	GO:0001666 GO:0005506 GO:0005783 GO:0005789 GO:0008475 GO:0008544 GO:0017185 GO:0030867 GO:0031418 GO:0070062 GO:1902494
GL_000320	Chondrolectin	Q9H9P2			Homo sapiens (human)	9606		carbohydrate binding centrosome cytoplasm cytosol endoplasmic reticulum membrane muscle organ development nervous system development perinuclear region of cytoplasm positive regulation of axonogenesis	GO:0005737 GO:0005789 GO:0005813 GO:0005829 GO:0007399 GO:0007517 GO:0030246 GO:0048471 GO:0050772
GL_000968	Protein FAM3A	P98173			Homo sapiens (human)	9606		antifungal humoral response antimicrobial humoral immune response mediated by antimicrobial peptide carbohydrate binding extracellular space negative regulation of antifungal innate immune response	GO:0005615 GO:0019732 GO:0030246 GO:0061844 GO:1905035
GL_001113	Sialic acid-binding Ig-like lectin 11	Q96RL6			Homo sapiens (human)	9606		carbohydrate binding cell adhesion phosphatase binding plasma membrane sialic acid binding	GO:0005886 GO:0007155 GO:0019902 GO:0030246 GO:0033691
GL_001127	Sialoadhesin	Q9BZZ2			Homo sapiens (human)	9606		carbohydrate binding cell-cell adhesion cell-matrix adhesion clathrin-dependent endocytosis of virus by host cell early endosome extracellular region inflammatory response late endosome membrane negative regulation of type I interferon production plasma membrane virion binding	GO:0005576 GO:0005769 GO:0005770 GO:0005886 GO:0006954 GO:0007160 GO:0016020 GO:0030246 GO:0032480 GO:0046790 GO:0075512 GO:0098609
GL_000891	Polypeptide N-acetylgalactosaminyltransferase 11	Q8NCW6			Homo sapiens (human)	9606		Golgi apparatus Golgi membrane Notch binding Notch receptor processing Notch signaling involved in heart development O-glycan processing carbohydrate binding cilium assembly determination of left/right symmetry metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via threonine protein O-linked glycosylation regulation of Notch signaling pathway	GO:0000139 GO:0004653 GO:0005112 GO:0005794 GO:0006493 GO:0007220 GO:0007368 GO:0008593 GO:0016266 GO:0018243 GO:0030246 GO:0046872 GO:0060271 GO:0061314
GL_002053	Protein ERGIC-53	P49257	3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE		Homo sapiens (human)	9606		COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane Golgi membrane Golgi organization blood coagulation collagen-containing extracellular matrix endoplasmic reticulum membrane endoplasmic reticulum organization endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum extracellular exosome mannose binding membrane metal ion binding negative regulation of protein targeting to mitochondrion positive regulation of organelle organization protein folding protein transport sarcomere unfolded protein binding	GO:0000139 GO:0005537 GO:0005783 GO:0005789 GO:0005793 GO:0006457 GO:0006888 GO:0007029 GO:0007030 GO:0007596 GO:0010638 GO:0012507 GO:0015031 GO:0016020 GO:0030017 GO:0030134 GO:0033116 GO:0046872 GO:0051082 GO:0062023 GO:0070062 GO:1903215
GL_000534	Grifin	A4D1Z8			Homo sapiens (human)	9606		carbohydrate binding	GO:0030246
GL_000802	Natural killer cells antigen CD94	Q13241	1B6E 3BDW 3CDG 3CII		Homo sapiens (human)	9606		HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding MHC class Ib protein binding, via antigen binding groove adaptive immune response carbohydrate binding cell surface receptor signaling pathway external side of plasma membrane natural killer cell mediated immunity negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0007166 GO:0009897 GO:0023024 GO:0023030 GO:0030246 GO:0032814 GO:0043235 GO:0045953 GO:0045954 GO:0062082 GO:1990405
GL_004965	Dopamine beta-hydroxylase	P09172	4ZEL		Homo sapiens (human)	9606		L-ascorbic acid binding behavioral response to ethanol blood vessel remodeling catalytic activity centriolar satellite chemical synaptic transmission chromaffin granule lumen chromaffin granule membrane copper ion binding cytoplasm dopamine beta-monooxygenase activity dopamine catabolic process endoplasmic reticulum extracellular region extracellular space fear response glucose homeostasis homoiothermy intracellular membrane-bounded organelle leukocyte mediated immunity leukocyte migration locomotory behavior maternal behavior membrane memory norepinephrine biosynthetic process octopamine biosynthetic process positive regulation of cold-induced thermogenesis positive regulation of vasoconstriction regulation of extrinsic apoptotic signaling pathway regulation of vascular associated smooth muscle cell proliferation regulation of vascular endothelial cell proliferation response to amphetamine response to pain secretory granule lumen secretory granule membrane synapse transport vesicle membrane vasoconstriction visual learning	GO:0001974 GO:0001975 GO:0002443 GO:0003824 GO:0004500 GO:0005507 GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0006589 GO:0007268 GO:0007613 GO:0007626 GO:0008542 GO:0016020 GO:0030658 GO:0030667 GO:0031418 GO:0034451 GO:0034466 GO:0034774 GO:0042309 GO:0042310 GO:0042420 GO:0042421 GO:0042584 GO:0042593 GO:0042596 GO:0042711 GO:0043231 GO:0045202 GO:0045907 GO:0048149 GO:0048265 GO:0050900 GO:0120162 GO:1904705 GO:1905562 GO:2001236
GL_000482	Galectin-10	Q05315	1G86 1HDK 1LCL 1QKQ 5XRG 5XRH 5XRI 5XRJ 5XRK 5XRL 5XRM 5XRN 5XRO 5XRP 5YT4 6A1S 6A1T 6A1U 6A1V 6A1X 6A1Y 6GKQ 6GKS 6GKT 6GKU 6GLW 6GLX 6L64 6L67 6L68 6L6A 6L6B 6L6C 6L6D 6QRN		Homo sapiens (human)	9606		T cell apoptotic process carbohydrate binding collagen-containing extracellular matrix cysteine-type endopeptidase activity involved in apoptotic process cytosol identical protein binding regulation of T cell anergy regulation of T cell cytokine production regulation of activated T cell proliferation	GO:0002667 GO:0002724 GO:0005829 GO:0030246 GO:0042802 GO:0046006 GO:0062023 GO:0070231 GO:0097153
GL_003160	Protein phosphatase 1 regulatory subunit 3B	Q86XI6	2EEF 5ZT0		Homo sapiens (human)	9606		[phosphorylase] phosphatase activity glycogen binding glycogen granule glycogen metabolic process protein phosphatase 1 binding protein phosphatase regulator activity protein phosphatase type 1 complex regulation of glycogen biosynthetic process regulation of glycogen catabolic process	GO:0000164 GO:0005977 GO:0005979 GO:0005981 GO:0008157 GO:0019888 GO:0042587 GO:0050196 GO:2001069
GL_005175	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	O60568	6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE		Homo sapiens (human)	9606		Golgi apparatus L-ascorbic acid binding basement membrane assembly collagen fibril organization collagen metabolic process collagen-containing extracellular matrix endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum endothelial cell morphogenesis epidermis morphogenesis extracellular exosome extracellular space hydroxylysine biosynthetic process in utero embryonic development iron ion binding lung morphogenesis metal ion binding neural tube development peptidyl-lysine hydroxylation procollagen galactosyltransferase activity procollagen glucosyltransferase activity procollagen-lysine 5-dioxygenase activity protein O-linked glycosylation protein localization rough endoplasmic reticulum small molecule binding trans-Golgi network vasodilation	GO:0001701 GO:0001886 GO:0005506 GO:0005615 GO:0005783 GO:0005788 GO:0005789 GO:0005791 GO:0005794 GO:0005802 GO:0006493 GO:0008104 GO:0008475 GO:0017185 GO:0021915 GO:0030199 GO:0031418 GO:0032963 GO:0033823 GO:0036094 GO:0042311 GO:0046872 GO:0046947 GO:0048730 GO:0050211 GO:0060425 GO:0062023 GO:0070062 GO:0070831
GL_002302	C-reactive protein	P02741	1B09 1GNH 1LJ7 3L2Y 3PVN 3PVO 7PK9 7PKB 7PKD 7PKE 7PKF 7PKG 7PKH 7TBA		Homo sapiens (human)	9606		acute-phase response calcium ion binding choline binding complement component C1q complex binding defense response to Gram-positive bacterium extracellular region extracellular space identical protein binding inflammatory response innate immune response low-density lipoprotein particle binding low-density lipoprotein particle receptor binding negative regulation of lipid storage negative regulation of macrophage derived foam cell differentiation negative regulation of mononuclear cell proliferation opsonization positive regulation of gene expression positive regulation of superoxide anion generation regulation of interleukin-8 production vasoconstriction	GO:0001849 GO:0005509 GO:0005576 GO:0005615 GO:0006953 GO:0006954 GO:0008228 GO:0010628 GO:0010745 GO:0010888 GO:0030169 GO:0032677 GO:0032930 GO:0032945 GO:0033265 GO:0042310 GO:0042802 GO:0045087 GO:0050750 GO:0050830
GL_002536	Hexokinase-1	P19367	1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB		Homo sapiens (human)	9606		ATP binding canonical glycolysis carbohydrate phosphorylation cytosol establishment of protein localization to mitochondrion fructokinase activity fructose 6-phosphate metabolic process glucokinase activity glucosamine kinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process hexokinase activity inflammatory response innate immune response intracellular glucose homeostasis maintenance of protein location in mitochondrion mannokinase activity mannose metabolic process membrane raft mitochondrial outer membrane mitochondrion peptidoglycan binding positive regulation of cytokine production involved in immune response positive regulation of interleukin-1 beta production	GO:0001678 GO:0002720 GO:0004340 GO:0004396 GO:0005524 GO:0005536 GO:0005739 GO:0005741 GO:0005829 GO:0006002 GO:0006006 GO:0006013 GO:0006096 GO:0006954 GO:0008865 GO:0019158 GO:0032731 GO:0042834 GO:0045087 GO:0045121 GO:0046835 GO:0047931 GO:0051156 GO:0061621 GO:0072655 GO:0072656
GL_001120	Sialic acid-binding Ig-like lectin 6	O43699			Homo sapiens (human)	9606		carbohydrate binding cell adhesion cell-cell signaling cytosol extracellular region membrane plasma membrane sialic acid binding	GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0007267 GO:0016020 GO:0030246 GO:0033691
GL_000185	C-type lectin domain family 4 member F	Q8N1N0			Homo sapiens (human)	9606		carbohydrate binding endocytosis external side of plasma membrane	GO:0006897 GO:0009897 GO:0030246
GL_000842	Pancreatic adenocarcinoma up-regulated factor	Q96DA0	3AQG		Homo sapiens (human)	9606		apicolateral plasma membrane carbohydrate binding cell migration cytoplasm extracellular exosome extracellular region extracellular space plasma membrane	GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0016327 GO:0016477 GO:0030246 GO:0070062
GL_001648	Hematopoietic progenitor cell antigen CD34	P28906			Homo sapiens (human)	9606		RNA polymerase II-specific DNA-binding transcription factor binding apical plasma membrane basal plasma membrane carbohydrate binding cell motility cell-cell adhesion cell-matrix adhesion cytoplasm endothelial cell proliferation endothelium development external side of plasma membrane extracellular exosome assembly extracellular region glomerular endothelium development glomerular endothelium fenestra glomerular filtration hematopoietic stem cell proliferation hemopoiesis intercellular bridge leukocyte migration lysosome mesangial cell-matrix adhesion metanephric glomerular mesangial cell differentiation negative regulation of gene expression negative regulation of interleukin-2 production paracrine signaling perinuclear region of cytoplasm plasma membrane positive regulation of angiogenesis positive regulation of gene expression positive regulation of granulocyte colony-stimulating factor production positive regulation of odontogenesis positive regulation of vasculogenesis signal transduction stem cell proliferation sulfate binding tissue homeostasis transdifferentiation vascular wound healing	GO:0001894 GO:0001935 GO:0003094 GO:0003158 GO:0005576 GO:0005737 GO:0005764 GO:0005886 GO:0007160 GO:0007165 GO:0009897 GO:0009925 GO:0010628 GO:0010629 GO:0016324 GO:0030097 GO:0030246 GO:0032703 GO:0035759 GO:0036053 GO:0038001 GO:0042482 GO:0043199 GO:0045171 GO:0045766 GO:0048471 GO:0048870 GO:0050900 GO:0060290 GO:0061042 GO:0061629 GO:0071425 GO:0071657 GO:0071971 GO:0072011 GO:0072089 GO:0072254 GO:0098609 GO:2001214
GL_001117	Sialic acid-binding Ig-like lectin 14	Q08ET2			Homo sapiens (human)	9606		carbohydrate binding cell adhesion ficolin-1-rich granule membrane plasma membrane sialic acid binding tertiary granule membrane	GO:0005886 GO:0007155 GO:0030246 GO:0033691 GO:0070821 GO:0101003
GL_000779	Myelin-associated glycoprotein	P20916			Homo sapiens (human)	9606		Schmidt-Lanterman incisure axon regeneration carbohydrate binding cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cellular response to mechanical stimulus central nervous system myelin formation compact myelin ganglioside GT1b binding membrane raft mesaxon myelin sheath adaxonal region myelin sheath negative regulation of axon extension negative regulation of neuron apoptotic process negative regulation of neuron differentiation negative regulation of neuron projection development paranode region of axon plasma membrane positive regulation of astrocyte differentiation positive regulation of myelination protein homodimerization activity protein kinase binding sialic acid binding signaling receptor binding substantia nigra development transmission of nerve impulse	GO:0005102 GO:0005886 GO:0007155 GO:0010977 GO:0019226 GO:0019901 GO:0021762 GO:0030246 GO:0030517 GO:0031103 GO:0031643 GO:0032289 GO:0033270 GO:0033691 GO:0035749 GO:0042803 GO:0043209 GO:0043218 GO:0043220 GO:0043524 GO:0045121 GO:0045665 GO:0048711 GO:0071260 GO:0097453 GO:0098742 GO:1905576
GL_000150	C-type lectin domain family 19 member A	Q6UXS0			Homo sapiens (human)	9606		carbohydrate binding extracellular region signaling receptor activity	GO:0005576 GO:0030246 GO:0038023
GL_000509	Galectin-8 Aliases: Galectin-8	O00214	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8HL9	LfDB0273	Homo sapiens (human)	9606	4565	carbohydrate binding cellular response to virus cytoplasm cytoplasmic vesicle cytosol extracellular space integrin binding lymphatic endothelial cell migration membrane xenophagy	GO:0005178 GO:0005615 GO:0005737 GO:0005829 GO:0016020 GO:0030246 GO:0031410 GO:0098586 GO:0098792 GO:1904977

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