GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **51 - 75** of **298** in total

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GlyCosmos Lectin ▲	Lectin Name	UniProt ID	PDB IDs	LfDB IDs	Monosaccharide Specificities	Organism	Taxonomy ID	MCAW IDs	Gene Ontology	Gene Ontology ID
GL_000384	Ficolin-1	O00602	2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP			Homo sapiens (human)	9606	3259 3262 3264	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway external side of plasma membrane extracellular region extracellular space ficolin-1-rich granule lumen metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteolysis recognition of apoptotic cell secretory granule lumen serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0009897 GO:0030246 GO:0032757 GO:0033691 GO:0034394 GO:0034774 GO:0038187 GO:0043654 GO:0046597 GO:0046872 GO:0062023 GO:0097367 GO:1903028 GO:1904813 GO:1905370
GL_000393	Ficolin-3	O75636	2J5Z 2J60 2J64			Homo sapiens (human)	9606		antigen binding blood microparticle carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway complement activation defense response to virus external side of plasma membrane extracellular region extracellular space metal ion binding negative regulation of RNA biosynthetic process negative regulation of viral entry into host cell positive regulation of opsonization proteolysis recognition of apoptotic cell serine-type endopeptidase complex signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0006508 GO:0006956 GO:0009897 GO:0030246 GO:0043654 GO:0046597 GO:0046872 GO:0051607 GO:0062023 GO:0072562 GO:0097367 GO:1902679 GO:1903028 GO:1905370
GL_000397	FRAS1-related extracellular matrix protein 1	Q5H8C1				Homo sapiens (human)	9606		anatomical structure morphogenesis basement membrane carbohydrate binding cell communication cell-matrix adhesion collagen-containing extracellular matrix craniofacial suture morphogenesis extracellular region membrane metal ion binding	GO:0005576 GO:0005604 GO:0007154 GO:0007160 GO:0009653 GO:0016020 GO:0030246 GO:0046872 GO:0062023 GO:0097094
GL_000466	Galactoside-binding soluble lectin 13	Q9UHV8	5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY			Homo sapiens (human)	9606		apoptotic process carbohydrate binding collagen-containing extracellular matrix cytoplasm lysophospholipase activity nuclear body nuclear matrix nucleoplasm phospholipid metabolic process	GO:0004622 GO:0005654 GO:0005737 GO:0006644 GO:0006915 GO:0016363 GO:0016604 GO:0030246 GO:0062023
GL_000469	Galectin-1 Aliases: Galectin-1	P09382	1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59 4Q1P 4Q1R 4Q26 4Q27 4Q2F 4XBL 4Y1U 4Y1V 4Y1X 4Y1Y 4Y1Z 4Y20 4Y22 4Y24 5MWT 5MWX 6B94 6F83 6M5Y 7LTA 7NML 8B0W 8B0Z	LfDB0270		Homo sapiens (human)	9606	1273 1290 1291 1292 1720 1723 1724 1725 295 296 2985 2989 2991 2992 2993 2996 416 417 5109	RNA binding T cell costimulation apoptotic process cell-cell adhesion collagen-containing extracellular matrix cytoplasm cytosol endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space galactoside binding galectin complex lactose binding laminin binding myoblast differentiation plasma cell differentiation positive regulation of apoptotic process positive regulation of canonical NF-kappaB signal transduction positive regulation of inflammatory response positive regulation of viral entry into host cell regulation of apoptotic process	GO:0002317 GO:0003723 GO:0005576 GO:0005615 GO:0005737 GO:0005788 GO:0005829 GO:0006915 GO:0016936 GO:0030395 GO:0031295 GO:0042981 GO:0043065 GO:0043123 GO:0043236 GO:0045445 GO:0046598 GO:0050729 GO:0062023 GO:0070062 GO:0098609 GO:1990724
GL_000482	Galectin-10	Q05315	1G86 1HDK 1LCL 1QKQ 5XRG 5XRH 5XRI 5XRJ 5XRK 5XRL 5XRM 5XRN 5XRO 5XRP 5YT4 6A1S 6A1T 6A1U 6A1V 6A1X 6A1Y 6GKQ 6GKS 6GKT 6GKU 6GLW 6GLX 6L64 6L67 6L68 6L6A 6L6B 6L6C 6L6D 6QRN			Homo sapiens (human)	9606		T cell apoptotic process carbohydrate binding collagen-containing extracellular matrix cysteine-type endopeptidase activity involved in apoptotic process cytosol identical protein binding regulation of T cell anergy regulation of T cell cytokine production regulation of activated T cell proliferation	GO:0002667 GO:0002724 GO:0005829 GO:0030246 GO:0042802 GO:0046006 GO:0062023 GO:0070231 GO:0097153
GL_000487	Galectin-2 Aliases: Galectin-2 (Human)	P05162	1HLC 5DG1 5DG2 5EWS	LfDB0055	Gal	Homo sapiens (human)	9606	5110	T cell homeostasis carbohydrate binding cell-cell adhesion galactoside binding galectin complex positive regulation of apoptotic process positive regulation of inflammatory response	GO:0016936 GO:0030246 GO:0043029 GO:0043065 GO:0050729 GO:0098609 GO:1990724
GL_000491	Galectin-3 Aliases: Gal3 Galectin-3 (Human)	P17931	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6RZF 6RZG 6RZH 6RZI 6RZJ 6RZK 6RZL 6RZM 6TF6 6TF7 6Y4C 6Y78 6ZVF 7BE3 7CXA 7DF5 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX 8BZ3 8OJI 8OJK 8OJM 8OJO 8PBF 8PF9 8PFF 8PPN	LfDB0056 LfDB0065	Gal	Homo sapiens (human)	9606	103 104 106 107 108 115 116 5108	IgE binding RNA binding RNA splicing carbohydrate binding cell surface chemoattractant activity collagen-containing extracellular matrix cytoplasm cytosol disaccharide binding eosinophil chemotaxis epithelial cell differentiation extracellular exosome extracellular region extracellular space ficolin-1-rich granule membrane immunological synapse innate immune response laminin binding mRNA processing macrophage chemotaxis membrane mitochondrial inner membrane molecular condensate scaffold activity monocyte chemotaxis mononuclear cell migration negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell receptor signaling pathway negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway negative regulation of immunological synapse formation negative regulation of protein tyrosine phosphatase activity neutrophil chemotaxis nucleoplasm nucleus plasma membrane positive chemotaxis positive regulation of calcium ion import positive regulation of mononuclear cell migration positive regulation of protein localization to plasma membrane positive regulation of protein-containing complex assembly protein phosphatase binding protein phosphatase inhibitor activity regulation of T cell apoptotic process regulation of T cell proliferation regulation of extrinsic apoptotic signaling pathway via death domain receptors secretory granule membrane spliceosomal complex	GO:0001772 GO:0002548 GO:0003723 GO:0004864 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005681 GO:0005737 GO:0005743 GO:0005829 GO:0005886 GO:0006397 GO:0008380 GO:0009986 GO:0016020 GO:0019863 GO:0019903 GO:0030246 GO:0030593 GO:0030667 GO:0030855 GO:0031334 GO:0042056 GO:0042129 GO:0043236 GO:0045087 GO:0045806 GO:0048030 GO:0048245 GO:0048246 GO:0050860 GO:0050918 GO:0062023 GO:0070062 GO:0070232 GO:0071674 GO:0071677 GO:0090280 GO:0101003 GO:0140693 GO:1902041 GO:1903078 GO:1903614 GO:2000521 GO:2001189 GO:2001237
GL_000501	Galectin-4 Aliases: Galectin-4	P56470	1X50 4XZP 4YLZ 4YM0 4YM1 4YM2 4YM3 5CBL 5DUU 5DUV 5DUW 5DUX 6WAB	LfDB0272		Homo sapiens (human)	9606	523	antibacterial peptide biosynthetic process carbohydrate binding cell adhesion collagen-containing extracellular matrix cytosol extracellular space galactoside binding plasma membrane	GO:0002780 GO:0005615 GO:0005829 GO:0005886 GO:0007155 GO:0016936 GO:0030246 GO:0062023
GL_000507	Galectin-7 Aliases: Galectin-7 (Human)	P47929	1BKZ 2GAL 3GAL 3ZXE 3ZXF 4GAL 4UW3 4UW4 4UW5 4UW6 4XBQ 4Y26 5GAL 5H9Q 5H9S 6VTO 6VTP 6VTQ 6VTR 6VTS 7N4O 7N57 7N6C 7N8D 7N8G 7N96 7RDG 7TKW 7TKX 7TKY 7TKZ 7TRN 7TRO 7XAC 7XBL	LfDB0058	Gal	Homo sapiens (human)	9606	1461 1702 1703 1710 5107	apoptotic process carbohydrate binding cytoplasm extracellular exosome extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nucleus	GO:0005615 GO:0005634 GO:0005737 GO:0006915 GO:0007157 GO:0030246 GO:0070062
GL_000509	Galectin-8 Aliases: Galectin-8	O00214	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8HL9	LfDB0273		Homo sapiens (human)	9606	4565	carbohydrate binding cellular response to virus cytoplasm cytoplasmic vesicle cytosol extracellular space integrin binding lymphatic endothelial cell migration membrane xenophagy	GO:0005178 GO:0005615 GO:0005737 GO:0005829 GO:0016020 GO:0030246 GO:0031410 GO:0098586 GO:0098792 GO:1904977
GL_000514	Galectin-9 Aliases: Galectin-9	O00182	2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	LfDB0274		Homo sapiens (human)	9606	1935 2987	ERK1 and ERK2 cascade carbohydrate binding cellular response to type II interferon cellular response to virus chemotaxis collagen-containing extracellular matrix cytoplasm cytosol disaccharide binding enzyme binding extracellular space female pregnancy galactose binding galactoside binding inflammatory response maternal process involved in female pregnancy natural killer cell tolerance induction negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of activated T cell proliferation negative regulation of chemokine production negative regulation of gene expression negative regulation of mast cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of tumor necrosis factor production negative regulation of type II interferon production nucleus p38MAPK cascade positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of NF-kappaB transcription factor activity positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of activated T cell autonomous cell death positive regulation of canonical NF-kappaB signal transduction positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell chemotaxis positive regulation of dendritic cell differentiation positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of monocyte chemotactic protein-1 production positive regulation of non-canonical NF-kappaB signal transduction positive regulation of transforming growth factor beta production positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of viral entry into host cell response to interleukin-1 response to lipopolysaccharide	GO:0002519 GO:0005534 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0006935 GO:0006954 GO:0007565 GO:0010628 GO:0010629 GO:0016936 GO:0019899 GO:0030246 GO:0032496 GO:0032682 GO:0032689 GO:0032720 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032736 GO:0032753 GO:0032755 GO:0032757 GO:0032760 GO:0032834 GO:0038066 GO:0043123 GO:0043305 GO:0045953 GO:0046007 GO:0046598 GO:0048030 GO:0051092 GO:0060135 GO:0062023 GO:0070241 GO:0070371 GO:0070374 GO:0070555 GO:0071346 GO:0071636 GO:0071639 GO:0098586 GO:1901224 GO:2000510 GO:2000562 GO:2000563 GO:2000670 GO:2001190 GO:2001200 GO:2001269
GL_000516	Galectin-9B	Q3B8N2				Homo sapiens (human)	9606		carbohydrate binding cytosol galactoside binding negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of type II interferon production nucleus positive regulation of gene expression	GO:0005634 GO:0005829 GO:0010628 GO:0016936 GO:0030246 GO:0032689 GO:2000562
GL_000517	Galectin-9C	Q6DKI2				Homo sapiens (human)	9606		carbohydrate binding cytosol galactoside binding negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of type II interferon production nucleus positive regulation of gene expression	GO:0005634 GO:0005829 GO:0010628 GO:0016936 GO:0030246 GO:0032689 GO:2000562
GL_000519	Galectin-related protein	Q3ZCW2	2JJ6 3B9C			Homo sapiens (human)	9606		carbohydrate binding	GO:0030246
GL_000534	Grifin	A4D1Z8				Homo sapiens (human)	9606		carbohydrate binding	GO:0030246
GL_000551	Inactive cell surface hyaluronidase CEMIP2	Q9UHN6	8C6I			Homo sapiens (human)	9606		angiogenesis cadherin binding calcium ion binding carbohydrate binding cytosol extracellular exosome hyaluronan catabolic process intracellular membrane-bounded organelle membrane nucleolus plasma membrane regulation of sprouting angiogenesis	GO:0001525 GO:0005509 GO:0005730 GO:0005829 GO:0005886 GO:0016020 GO:0030214 GO:0030246 GO:0043231 GO:0045296 GO:0070062 GO:1903670
GL_000555	Integral membrane protein DGCR2/IDD	P98153				Homo sapiens (human)	9606		animal organ morphogenesis carbohydrate binding cell adhesion cognition membrane	GO:0007155 GO:0009887 GO:0016020 GO:0030246 GO:0050890
GL_000611	Killer cell lectin-like receptor subfamily B member 1	Q12918	5MGR 5MGS 5MGT			Homo sapiens (human)	9606		carbohydrate binding cell surface receptor signaling pathway cell surface plasma membrane regulation of natural killer cell mediated cytotoxicity signaling receptor activity transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007166 GO:0009986 GO:0030246 GO:0038023 GO:0042269
GL_000625	Killer cell lectin-like receptor subfamily F member 1	Q9NZS2				Homo sapiens (human)	9606		MHC class I receptor activity carbohydrate binding cell surface receptor signaling pathway membrane plasma membrane transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007166 GO:0016020 GO:0030246 GO:0032393
GL_000627	Killer cell lectin-like receptor subfamily F member 2	D3W0D1	4IOP			Homo sapiens (human)	9606		carbohydrate binding natural killer cell degranulation plasma membrane positive regulation of cytokine production protein homodimerization activity	GO:0001819 GO:0005886 GO:0030246 GO:0042803 GO:0043320
GL_000629	Killer cell lectin-like receptor subfamily G member 1	Q96E93	3FF7			Homo sapiens (human)	9606		carbohydrate binding cell surface receptor signaling pathway cellular defense response inflammatory response innate immune response intracellular membrane-bounded organelle membrane plasma membrane signaling receptor activity	GO:0005886 GO:0006954 GO:0006968 GO:0007166 GO:0016020 GO:0030246 GO:0038023 GO:0043231 GO:0045087
GL_000631	Killer cell lectin-like receptor subfamily G member 2	A4D1S0				Homo sapiens (human)	9606		carbohydrate binding membrane	GO:0016020 GO:0030246
GL_000639	L-selectin	P14151	2LGF 3CFW 5VC1			Homo sapiens (human)	9606		calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding cell adhesion external side of plasma membrane extracellular space glycosphingolipid binding heparin binding heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte tethering or rolling oligosaccharide binding plasma membrane protease binding response to cytokine secretory granule membrane sialic acid binding	GO:0002020 GO:0005509 GO:0005615 GO:0005886 GO:0007155 GO:0007157 GO:0007159 GO:0008201 GO:0009897 GO:0016339 GO:0030246 GO:0030667 GO:0033691 GO:0034097 GO:0043208 GO:0050901 GO:0070492
GL_000679	Layilin	Q6UX15				Homo sapiens (human)	9606		carbohydrate binding cell surface focal adhesion hyaluronic acid binding membrane ruffle	GO:0001726 GO:0005540 GO:0005925 GO:0009986 GO:0016020 GO:0030246

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