GlyCosmos Portal

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Galectin-1

Summary

Lectin Name Aliases

Gal 1
Galectin-1
Human Galectin 1

Organism

Homo sapiens (human)

External Links

UniProt

P09382

LfDB

LfDB0270

UniLectin

P09382

CarboGrove

1024

Annotation

Keyword

3D-structure
Acetylation
Apoptosis
Cytoplasm
Direct protein sequencing
Extracellular matrix
Lectin
Phosphoprotein
Reference proteome

Gene Ontology (GO)

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GO Term
apoptotic process
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of inflammatory response
cell-cell adhesion
positive regulation of canonical NF-kappaB signal transduction
plasma cell differentiation
T cell costimulation
myoblast differentiation
positive regulation of viral entry into host cell

Displaying **all 9** entries
GO Term
endoplasmic reticulum lumen
cytosol
extracellular region
extracellular space
cytoplasm
plasma membrane
collagen-containing extracellular matrix
extracellular exosome
galectin complex

Displaying **all 4** entries
GO Term
laminin binding
RNA binding
receptor ligand activity
lactose binding

Annotation information from UniProt.

Reference

Displaying entries **1 - 10** of 21 in total

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PubMed ID	Title	First Author
7890631	Galectin-1, a beta-galactoside-binding lectin in Chinese hamster ovary cells. II. Localization and biosynthesis.	Cho M
7890630	Galectin-1, a beta-galactoside-binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization.	Cho M
10642604	Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells.	Walzel H
12925577	Altered T cell surface glycosylation in HIV-1 infection results in increased susceptibility to galectin-1-induced cell death.	Lantéri M
14638631	Galectin-1, a cell adhesion modulator, induces apoptosis of rat Leydig cells in vitro.	Martinez VG
14693909	Quaternary solution structures of galectins-1, -3, and -7.	Morris S
14693917	Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor.	Sasaki T
15148296	Thermodynamic binding studies of bivalent oligosaccharides to galectin-1, galectin-3, and the carbohydrate recognition domain of galectin-3.	Ahmad N
18633135	Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans.	Karmakar S
18723690	Degeneration of dystrophic or injured skeletal muscles induces high expression of Galectin-1.	Cerri DG

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens

UniLectin

UniProt
P09382

CarboGrove

Lectin Name: Human Galectin 1
Common Name: Gal 1

Automated Analysis report (Top 10 high affinity glycans)

Array Source

ASNLinked

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G03652TR	131.5	24.68
G63889NK	127.5	26.16
G28800UK	124.5	56.21
G73866ZM	119.5	28.87
G72506RN	118.5	75.64
G66741YQ	115.25	94.4
G18938DW	108.5	88.78
G45359RY	71	6.68
G79809MM	49.75	18.41
G78030KJ	32.5	27.04

GlyTouCan ID	Binding Intensity	Stdev
G18938DW	1893.5	141.53
G86357DX	1579.25	408.96
G63889NK	1545.75	144.23
G66741YQ	1098.25	106.24
G29857RC	1063.75	348.49
G45359RY	1005.5	155.8
G79809MM	1001.75	61.91
G78059CC	947.5	123.95
G03652TR	645.75	52.36
G36191CD	555	103.61

CarboGrove View

CarboGrove is populated with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies by processing and interpreting data from various types of glycan arrays.

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).