GlyCosmos Portal

Submissions

Galectin-1

Summary

Lectin Name Aliases

Gal 1
Galectin-1
Human Galectin 1

Organism

Homo sapiens (human)

External Links

UniProt

P09382

LfDB

LfDB0270

UniLectin

P09382

CarboGrove

1024

Annotation

Keyword

3D-structure
Acetylation
Apoptosis
Cytoplasm
Direct protein sequencing
Extracellular matrix
Lectin
Phosphoprotein
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

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GO Term
plasma cell differentiation
T cell costimulation
myoblast differentiation
positive regulation of viral entry into host cell
negative regulation of T-helper 17 cell lineage commitment
apoptotic process
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of inflammatory response
cell-cell adhesion

Displaying **all 9** entries
GO Term
endoplasmic reticulum lumen
cytosol
extracellular exosome
extracellular region
extracellular space
cytoplasm
plasma membrane
collagen-containing extracellular matrix
galectin complex

Displaying **all 4** entries
GO Term
lactose binding
laminin binding
RNA binding
receptor ligand activity

Annotation information from UniProt.

Reference

Displaying entries **11 - 20** of 21 in total

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PubMed ID	Title	First Author
18796645	Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1.	Nishi N
19635795	Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling.	Fulcher JA
21372130	The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins.	Salomonsson E
22942212	Galectin-1 promotes human neutrophil migration.	Auvynet C
23223580	The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells.	Jouve N
24451991	Structural basis of redox-dependent modulation of galectin-1 dynamics and function.	Guardia CM
26216879	Galectin-1 regulates tissue exit of specific dendritic cell populations.	Thiemann S
27222530	Impact of human galectin-1 binding to saccharide ligands on dimer dissociation kinetics and structure.	Romero JM
32280962	Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand.	Mendoza M
33498084	Tissue-specific control of galectin-1-driven circuits during inflammatory responses.	Cutine AM

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens

UniLectin

UniProt
P09382

CarboGrove

Lectin Name: Human Galectin 1
Common Name: Gal 1

Automated Analysis report (Top 10 high affinity glycans)

Array Source

ASNLinked

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G03652TR	131.5	24.68
G63889NK	127.5	26.16
G28800UK	124.5	56.21
G73866ZM	119.5	28.87
G72506RN	118.5	75.64
G66741YQ	115.25	94.4
G18938DW	108.5	88.78
G45359RY	71	6.68
G79809MM	49.75	18.41
G78030KJ	32.5	27.04

GlyTouCan ID	Binding Intensity	Stdev
G18938DW	1893.5	141.53
G86357DX	1579.25	408.96
G63889NK	1545.75	144.23
G66741YQ	1098.25	106.24
G29857RC	1063.75	348.49
G45359RY	1005.5	155.8
G79809MM	1001.75	61.91
G78059CC	947.5	123.95
G03652TR	645.75	52.36
G36191CD	555	103.61

CarboGrove View

CarboGrove is populated with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies by processing and interpreting data from various types of glycan arrays.

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).