GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **51 - 75** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	LfDB IDs	Monosaccharide Specificities	Organism ▲	Taxonomy ID	MCAW IDs	Gene Ontology	Gene Ontology ID
GL_002066	Regenerating islet-derived protein 3-gamma	Q6UW15				Homo sapiens (human)	9606		MyD88-dependent toll-like receptor signaling pathway acute-phase response antimicrobial humoral immune response mediated by antimicrobial peptide collagen-containing extracellular matrix cytoplasm defense response to Gram-positive bacterium disruption of cell wall in another organism extracellular region extracellular space metal ion binding negative regulation of keratinocyte differentiation oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation positive regulation of keratinocyte proliferation positive regulation of wound healing response to peptide hormone signaling receptor activity	GO:0002755 GO:0005576 GO:0005615 GO:0005737 GO:0006953 GO:0008284 GO:0010838 GO:0038023 GO:0042834 GO:0043434 GO:0044278 GO:0045617 GO:0046872 GO:0050830 GO:0061844 GO:0062023 GO:0070492 GO:0090303
GL_001183	1,4-alpha-glucan-branching enzyme	Q04446	4BZY 5CLT 5CLW			Homo sapiens (human)	9606		1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) 1,4-alpha-glucan branching enzyme activity carbohydrate binding cation binding cytoplasm cytosol extracellular exosome generation of precursor metabolites and energy glycogen biosynthetic process glycogen metabolic process hydrolase activity, hydrolyzing O-glycosyl compounds negative regulation of neuron apoptotic process starch metabolic process	GO:0003844 GO:0004553 GO:0005737 GO:0005829 GO:0005977 GO:0005978 GO:0005982 GO:0006091 GO:0030246 GO:0043169 GO:0043524 GO:0070062 GO:0102752
GL_000972	Protein FAM3B	P58499				Homo sapiens (human)	9606		apoptotic process carbohydrate binding cytokine activity extracellular exosome extracellular region extracellular space insulin secretion	GO:0005125 GO:0005576 GO:0005615 GO:0006915 GO:0030073 GO:0030246 GO:0070062
GL_000487	Galectin-2 Aliases: Galectin-2 (Human)	P05162	1HLC 5DG1 5DG2 5EWS	LfDB0055	Gal	Homo sapiens (human)	9606	5110	T cell homeostasis carbohydrate binding cell-cell adhesion galactoside binding galectin complex positive regulation of apoptotic process positive regulation of inflammatory response	GO:0016936 GO:0030246 GO:0043029 GO:0043065 GO:0050729 GO:0098609 GO:1990724
GL_002384	CD83 antigen	Q01151	5MIX 5MJ0 5MJ1 5MJ2			Homo sapiens (human)	9606		CD4-positive, alpha-beta T cell differentiation defense response external side of plasma membrane humoral immune response negative regulation of interleukin-4 production plasma membrane positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of interleukin-10 production positive regulation of interleukin-2 production response to organic cyclic compound signal transduction	GO:0005886 GO:0006952 GO:0006959 GO:0007165 GO:0009897 GO:0014070 GO:0032713 GO:0032733 GO:0032743 GO:0043367 GO:0043372
GL_000151	C-type lectin domain family 2 member A	Q6UVW9	4IOP			Homo sapiens (human)	9606		carbohydrate binding external side of plasma membrane natural killer cell mediated cytotoxicity plasma membrane protein homodimerization activity	GO:0005886 GO:0009897 GO:0030246 GO:0042267 GO:0042803
GL_003151	Protein phosphatase 1 regulatory subunit 3F	Q6ZSY5				Homo sapiens (human)	9606		glycogen binding membrane protein phosphatase 1 binding protein phosphatase binding protein phosphatase type 1 complex regulation of glycogen (starch) synthase activity regulation of glycogen biosynthetic process	GO:0000164 GO:0005979 GO:0008157 GO:0016020 GO:0019903 GO:2000465 GO:2001069
GL_005016	Prolyl hydroxylase EGLN2	Q96KS0	5V1B			Homo sapiens (human)	9606		2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding cell redox homeostasis cellular response to hypoxia cytoplasm ferrous iron binding hypoxia-inducible factor-proline dioxygenase activity intracellular estrogen receptor signaling pathway nucleoplasm nucleus oxygen sensor activity peptidyl-proline 4-dioxygenase activity peptidyl-proline hydroxylation to 4-hydroxy-L-proline positive regulation of protein catabolic process regulation of cell growth regulation of neuron apoptotic process response to hypoxia	GO:0001558 GO:0001666 GO:0005634 GO:0005654 GO:0005737 GO:0008198 GO:0016706 GO:0018401 GO:0019826 GO:0030520 GO:0031418 GO:0031545 GO:0043523 GO:0045454 GO:0045732 GO:0071456 GO:0160082
GL_000150	C-type lectin domain family 19 member A	Q6UXS0				Homo sapiens (human)	9606		carbohydrate binding extracellular region signaling receptor activity	GO:0005576 GO:0030246 GO:0038023
GL_000817	NKG2-A/NKG2-B type II integral membrane protein	P26715	2RMX 2YU7 3BDW 3CDG 3CII			Homo sapiens (human)	9606		CD8-positive, gamma-delta intraepithelial T cell differentiation HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding adaptive immune response carbohydrate binding cell surface receptor signaling pathway external side of plasma membrane inhibitory MHC class Ib receptor activity innate immune response natural killer cell inhibitory signaling pathway negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002250 GO:0002305 GO:0002769 GO:0004888 GO:0005886 GO:0007166 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0045087 GO:0045953 GO:0045954 GO:0062080 GO:0062082
GL_001114	Sialic acid-binding Ig-like lectin 12	Q96PQ1				Homo sapiens (human)	9606		carbohydrate binding cell adhesion plasma membrane sialic acid binding	GO:0005886 GO:0007155 GO:0030246 GO:0033691
GL_000469	Galectin-1 Aliases: Galectin-1	P09382	1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59 4Q1P 4Q1R 4Q26 4Q27 4Q2F 4XBL 4Y1U 4Y1V 4Y1X 4Y1Y 4Y1Z 4Y20 4Y22 4Y24 5MWT 5MWX 6B94 6F83 6M5Y 7LTA 7NML 8B0W 8B0Z	LfDB0270		Homo sapiens (human)	9606	1273 1290 1291 1292 1720 1723 1724 1725 295 296 2985 2989 2991 2992 2993 2996 416 417 5109	RNA binding T cell costimulation apoptotic process cell-cell adhesion collagen-containing extracellular matrix cytoplasm cytosol endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space galactoside binding galectin complex lactose binding laminin binding myoblast differentiation plasma cell differentiation positive regulation of apoptotic process positive regulation of canonical NF-kappaB signal transduction positive regulation of inflammatory response positive regulation of viral entry into host cell regulation of apoptotic process	GO:0002317 GO:0003723 GO:0005576 GO:0005615 GO:0005737 GO:0005788 GO:0005829 GO:0006915 GO:0016936 GO:0030395 GO:0031295 GO:0042981 GO:0043065 GO:0043123 GO:0043236 GO:0045445 GO:0046598 GO:0050729 GO:0062023 GO:0070062 GO:0098609 GO:1990724
GL_005250	Prolyl hydroxylase EGLN3	Q9H6Z9				Homo sapiens (human)	9606		2-oxoglutarate-dependent dioxygenase activity DNA damage response L-ascorbic acid binding activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process cellular response to hypoxia cytoplasm cytosol ferrous iron binding hypoxia-inducible factor-proline dioxygenase activity nucleoplasm nucleus peptidyl-proline 4-dioxygenase activity peptidyl-proline hydroxylation to 4-hydroxy-L-proline protein hydroxylation regulation of cell population proliferation regulation of neuron apoptotic process response to hypoxia	GO:0001666 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0006974 GO:0008198 GO:0016706 GO:0018126 GO:0018401 GO:0031418 GO:0031545 GO:0042127 GO:0043523 GO:0071456 GO:0160082
GL_001363	Beta-glucuronidase	P08236	1BHG 3HN3			Homo sapiens (human)	9606		azurophil granule lumen beta-glucuronidase activity carbohydrate binding carbohydrate metabolic process chondroitin sulfate catabolic process extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen glucuronoside catabolic process glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process hyaluronan catabolic process intracellular membrane-bounded organelle lysosomal lumen membrane protein domain specific binding signaling receptor binding	GO:0004566 GO:0005102 GO:0005576 GO:0005615 GO:0005975 GO:0006027 GO:0016020 GO:0019391 GO:0019904 GO:0030200 GO:0030207 GO:0030214 GO:0030246 GO:0035578 GO:0043202 GO:0043231 GO:0070062 GO:1904813
GL_002596	Hexokinase-4	P35557	1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I 7T78 7T79			Homo sapiens (human)	9606		ATP binding NADP metabolic process calcium ion import canonical glycolysis carbohydrate phosphorylation cellular response to insulin stimulus cellular response to leptin stimulus cytosol fructokinase activity glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose catabolic process glucose homeostasis glucose metabolic process glucose sensor activity glycolytic process intracellular glucose homeostasis mannokinase activity mitochondrion negative regulation of gluconeogenesis nucleoplasm positive regulation of glycogen biosynthetic process positive regulation of insulin secretion regulation of glycolytic process regulation of insulin secretion regulation of potassium ion transport response to glucose	GO:0001678 GO:0004340 GO:0005524 GO:0005536 GO:0005654 GO:0005739 GO:0005829 GO:0006006 GO:0006007 GO:0006096 GO:0006110 GO:0006739 GO:0008865 GO:0009749 GO:0019158 GO:0032024 GO:0032869 GO:0042593 GO:0043266 GO:0044320 GO:0045721 GO:0045725 GO:0046835 GO:0050796 GO:0051156 GO:0061621 GO:0070509 GO:0141089
GL_000908	Polypeptide N-acetylgalactosaminyltransferase 18	Q6P9A2				Homo sapiens (human)	9606		Golgi apparatus Golgi membrane carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0030246 GO:0046872
GL_001120	Sialic acid-binding Ig-like lectin 6	O43699				Homo sapiens (human)	9606		carbohydrate binding cell adhesion cell-cell signaling cytosol extracellular region membrane plasma membrane sialic acid binding	GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0007267 GO:0016020 GO:0030246 GO:0033691
GL_002002	E-selectin	P16581	1ESL 1G1T 4C16 4CSY 6EYI 6EYJ 6EYK			Homo sapiens (human)	9606		actin filament-based process activation of phospholipase C activity calcium-mediated signaling caveola clathrin-coated pit cortical cytoskeleton external side of plasma membrane extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules inflammatory response leukocyte cell-cell adhesion leukocyte migration involved in inflammatory response leukocyte tethering or rolling membrane raft metal ion binding oligosaccharide binding perinuclear region of cytoplasm phospholipase binding plasma membrane positive regulation of leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of receptor internalization regulation of inflammatory response response to cytokine response to interleukin-1 response to lipopolysaccharide response to tumor necrosis factor sialic acid binding transmembrane signaling receptor activity	GO:0002092 GO:0002523 GO:0002687 GO:0004888 GO:0005615 GO:0005886 GO:0005901 GO:0005905 GO:0006954 GO:0007157 GO:0007159 GO:0007202 GO:0009897 GO:0019722 GO:0030029 GO:0030863 GO:0032496 GO:0033691 GO:0034097 GO:0034612 GO:0043274 GO:0045121 GO:0046872 GO:0048471 GO:0050727 GO:0050901 GO:0070492 GO:0070555 GO:1903238
GL_001087	Secretory phospholipase A2 receptor	Q13018	6JLI 7QSR			Homo sapiens (human)	9606		carbohydrate binding cell surface extracellular region negative regulation of arachidonic acid secretion negative regulation of phospholipase A2 activity oxidative stress-induced premature senescence phospholipase binding plasma membrane positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of arachidonic acid secretion positive regulation of cytokine production positive regulation of podocyte apoptotic process reactive oxygen species metabolic process receptor complex receptor-mediated endocytosis replicative senescence signaling receptor activity	GO:0001819 GO:0005576 GO:0005886 GO:0006898 GO:0009986 GO:0030246 GO:0038023 GO:0043235 GO:0043274 GO:0043517 GO:0072593 GO:0090238 GO:0090399 GO:0090403 GO:1900138 GO:1900139 GO:1904635
GL_002041	Lithostathine-1-alpha	P05451	1LIT 1QDD			Homo sapiens (human)	9606		antimicrobial humoral immune response mediated by antimicrobial peptide collagen-containing extracellular matrix disruption of cell wall in another organism extracellular exosome extracellular space growth factor activity molecular function inhibitor activity oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation response to peptide hormone signaling receptor activity	GO:0005615 GO:0008083 GO:0008284 GO:0038023 GO:0042834 GO:0043434 GO:0044278 GO:0061844 GO:0062023 GO:0070062 GO:0070492 GO:0140678
GL_001029	Putative C-type lectin domain family 20 member A	Q6ZU45				Homo sapiens (human)	9606		carbohydrate binding	GO:0030246
GL_001123	Sialic acid-binding Ig-like lectin 9	Q9Y336				Homo sapiens (human)	9606		carbohydrate binding cell adhesion cell surface receptor signaling pathway plasma membrane secretory granule membrane sialic acid binding	GO:0005886 GO:0007155 GO:0007166 GO:0030246 GO:0030667 GO:0033691
GL_000927	Polypeptide N-acetylgalactosaminyltransferase 6	Q8NCL4				Homo sapiens (human)	9606		Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via threonine protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0018243 GO:0030246 GO:0046872 GO:0048471
GL_000466	Galactoside-binding soluble lectin 13	Q9UHV8	5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY			Homo sapiens (human)	9606		apoptotic process carbohydrate binding collagen-containing extracellular matrix cytoplasm lysophospholipase activity nuclear body nuclear matrix nucleoplasm phospholipid metabolic process	GO:0004622 GO:0005654 GO:0005737 GO:0006644 GO:0006915 GO:0016363 GO:0016604 GO:0030246 GO:0062023
GL_001376	BOS complex subunit NOMO1	Q15155				Homo sapiens (human)	9606		carbohydrate binding endoplasmic reticulum membrane membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane ribosome binding	GO:0005789 GO:0016020 GO:0030246 GO:0043022 GO:0160063 GO:0160064

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