GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **76 - 100** of **298** in total

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GlyCosmos Lectin ▲	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_000766	Low affinity immunoglobulin epsilon Fc receptor	P06734	1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK 6Y0L 6Y0M	Homo sapiens (human)	9606	B cell antigen processing and presentation Fc receptor-mediated immune complex endocytosis IgE binding carbohydrate binding external side of plasma membrane extracellular exosome immune response integrin binding low-affinity IgE receptor activity macrophage activation metal ion binding plasma membrane positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of killing of cells of another organism positive regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase biosynthetic process	GO:0002450 GO:0002925 GO:0005178 GO:0005886 GO:0006955 GO:0009897 GO:0019769 GO:0019863 GO:0030246 GO:0042116 GO:0046872 GO:0051000 GO:0051712 GO:0051770 GO:0070062 GO:0160006
GL_000768	Lymphocyte antigen 75	O60449	7JPT 7JPU 8HBC	Homo sapiens (human)	9606	carbohydrate binding endocytosis external side of plasma membrane extracellular exosome immune response inflammatory response plasma membrane signaling receptor activity	GO:0005886 GO:0006897 GO:0006954 GO:0006955 GO:0009897 GO:0030246 GO:0038023 GO:0070062
GL_000779	Myelin-associated glycoprotein	P20916		Homo sapiens (human)	9606	Schmidt-Lanterman incisure axon regeneration carbohydrate binding cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cellular response to mechanical stimulus central nervous system myelin formation compact myelin ganglioside GT1b binding membrane raft mesaxon myelin sheath adaxonal region myelin sheath negative regulation of axon extension negative regulation of neuron apoptotic process negative regulation of neuron differentiation negative regulation of neuron projection development paranode region of axon plasma membrane positive regulation of astrocyte differentiation positive regulation of myelination protein homodimerization activity protein kinase binding sialic acid binding signaling receptor binding substantia nigra development transmission of nerve impulse	GO:0005102 GO:0005886 GO:0007155 GO:0010977 GO:0019226 GO:0019901 GO:0021762 GO:0030246 GO:0030517 GO:0031103 GO:0031643 GO:0032289 GO:0033270 GO:0033691 GO:0035749 GO:0042803 GO:0043209 GO:0043218 GO:0043220 GO:0043524 GO:0045121 GO:0045665 GO:0048711 GO:0071260 GO:0097453 GO:0098742 GO:1905576
GL_000782	Myeloid cell surface antigen CD33	P20138	5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8 7AW6	Homo sapiens (human)	9606	Golgi apparatus carbohydrate binding cell adhesion cell surface cell-cell adhesion cell-cell signaling external side of plasma membrane immune response-inhibiting signal transduction negative regulation of calcium ion transport negative regulation of cell population proliferation negative regulation of interleukin-1 beta production negative regulation of interleukin-8 production negative regulation of monocyte activation negative regulation of tumor necrosis factor production nucleoplasm peroxisome plasma membrane positive regulation of protein secretion positive regulation of protein tyrosine phosphatase activity protein phosphatase binding sialic acid binding signal transduction signaling receptor activity specific granule membrane tertiary granule membrane	GO:0002765 GO:0005654 GO:0005777 GO:0005794 GO:0005886 GO:0007155 GO:0007165 GO:0007267 GO:0008285 GO:0009897 GO:0009986 GO:0019903 GO:0030246 GO:0032691 GO:0032717 GO:0032720 GO:0033691 GO:0035579 GO:0038023 GO:0050714 GO:0051926 GO:0070821 GO:0098609 GO:0150102 GO:1903615
GL_000794	N-acetylgalactosaminyltransferase 7	Q86SF2	6IWQ 6IWR	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding carbohydrate metabolic process extracellular exosome membrane metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0005975 GO:0006493 GO:0016020 GO:0016266 GO:0030246 GO:0046872 GO:0070062
GL_000802	Natural killer cells antigen CD94	Q13241	1B6E 3BDW 3CDG 3CII	Homo sapiens (human)	9606	HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding MHC class Ib protein binding, via antigen binding groove adaptive immune response carbohydrate binding cell surface receptor signaling pathway external side of plasma membrane natural killer cell mediated immunity negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0007166 GO:0009897 GO:0023024 GO:0023030 GO:0030246 GO:0032814 GO:0043235 GO:0045953 GO:0045954 GO:0062082 GO:1990405
GL_000807	Neurocan core protein	O14594		Homo sapiens (human)	9606	Golgi lumen calcium ion binding carbohydrate binding cell adhesion central nervous system development extracellular region extracellular space glial cell differentiation hyaluronic acid binding lysosomal lumen perineuronal net positive regulation of neuroblast proliferation skeletal system development synapse	GO:0001501 GO:0002052 GO:0005509 GO:0005540 GO:0005576 GO:0005615 GO:0005796 GO:0007155 GO:0007417 GO:0010001 GO:0030246 GO:0043202 GO:0045202 GO:0072534
GL_000811	Neuronal pentraxin-2	P47972		Homo sapiens (human)	9606	associative learning carbohydrate binding chemical synaptic transmission extracellular region glutamatergic synapse metal ion binding	GO:0005576 GO:0007268 GO:0008306 GO:0030246 GO:0046872 GO:0098978
GL_000817	NKG2-A/NKG2-B type II integral membrane protein	P26715	2RMX 2YU7 3BDW 3CDG 3CII	Homo sapiens (human)	9606	CD8-positive, gamma-delta intraepithelial T cell differentiation HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding adaptive immune response carbohydrate binding cell surface receptor signaling pathway external side of plasma membrane inhibitory MHC class Ib receptor activity innate immune response natural killer cell inhibitory signaling pathway negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002250 GO:0002305 GO:0002769 GO:0004888 GO:0005886 GO:0007166 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0045087 GO:0045953 GO:0045954 GO:0062080 GO:0062082
GL_000820	NKG2-C type II integral membrane protein	P26717	2L35	Homo sapiens (human)	9606	MHC class I protein complex binding activating MHC class Ib receptor activity adaptive immune response carbohydrate binding cellular defense response external side of plasma membrane natural killer cell mediated immunity plasma membrane positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation signal transduction stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0006968 GO:0007165 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0043323 GO:0045954 GO:0062081 GO:1990405
GL_000823	NKG2-D type II integral membrane protein	P26718	1HYR 1KCG 1MPU 4PDC 4S0U	Homo sapiens (human)	9606	MHC class I protein binding MHC class Ib receptor activity T cell costimulation adaptive immune response carbohydrate binding cell differentiation cell surface cellular response to lipopolysaccharide defense response to Gram-positive bacterium external side of plasma membrane identical protein binding membrane natural killer cell activation natural killer cell mediated cytotoxicity negative regulation of GTPase activity negative regulation of natural killer cell chemotaxis nitric oxide biosynthetic process plasma membrane positive regulation of natural killer cell mediated cytotoxicity positive regulation of nitric oxide biosynthetic process positive regulation of type II interferon production signal transduction signaling receptor activity stimulatory C-type lectin receptor signaling pathway	GO:0002223 GO:0002250 GO:0005886 GO:0006809 GO:0007165 GO:0009897 GO:0009986 GO:0016020 GO:0030101 GO:0030154 GO:0030246 GO:0031295 GO:0032394 GO:0032729 GO:0034260 GO:0038023 GO:0042267 GO:0042288 GO:0042802 GO:0045429 GO:0045954 GO:0050830 GO:0071222 GO:2000502
GL_000829	NKG2-E type II integral membrane protein	Q07444		Homo sapiens (human)	9606	carbohydrate binding cellular defense response external side of plasma membrane plasma membrane positive regulation of natural killer cell mediated cytotoxicity receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0004888 GO:0005886 GO:0006968 GO:0009897 GO:0030246 GO:0032814 GO:0043235 GO:0045954
GL_000835	Oxidized low-density lipoprotein receptor 1	P78380	1YPO 1YPQ 1YPU 1YXJ 1YXK 3VLG 6TL7 6TL9 6TLA 7R8U 7W5D 7XMP	Homo sapiens (human)	9606	blood circulation carbohydrate binding extracellular region identical protein binding immune system process inflammatory response intracellular membrane-bounded organelle leukocyte cell-cell adhesion lipoprotein metabolic process low-density lipoprotein particle receptor activity membrane raft membrane nucleoplasm plasma membrane proteolysis receptor complex specific granule membrane tertiary granule membrane	GO:0002376 GO:0005041 GO:0005576 GO:0005654 GO:0005886 GO:0006508 GO:0006954 GO:0007159 GO:0008015 GO:0016020 GO:0030246 GO:0035579 GO:0042157 GO:0042802 GO:0043231 GO:0043235 GO:0045121 GO:0070821
GL_000842	Pancreatic adenocarcinoma up-regulated factor	Q96DA0	3AQG	Homo sapiens (human)	9606	apicolateral plasma membrane carbohydrate binding cell migration cytoplasm extracellular exosome extracellular region extracellular space plasma membrane	GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0016327 GO:0016477 GO:0030246 GO:0070062
GL_000874	Placental protein 13-like	Q8TCE9	6K2Y 6K2Z	Homo sapiens (human)	9606	apoptotic process carbohydrate binding collagen-containing extracellular matrix nucleoplasm	GO:0005654 GO:0006915 GO:0030246 GO:0062023
GL_000876	Polycystin-1	P98161	1B4R 6A70	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane Golgi-associated vesicle membrane Wnt receptor activity anatomical structure morphogenesis basolateral plasma membrane branching morphogenesis of an epithelial tube calcium channel activity calcium channel complex calcium ion transmembrane transport calcium ion transport calcium-independent cell-matrix adhesion carbohydrate binding cartilage condensation cartilage development cation channel complex cell surface cell-cell signaling by wnt cell-matrix adhesion ciliary membrane cilium cytoplasm detection of mechanical stimulus digestive tract development embryonic placenta development endoplasmic reticulum establishment of epithelial cell polarity extracellular exosome genitalia development heart development homophilic cell adhesion via plasma membrane adhesion molecules in utero embryonic development kidney development lateral plasma membrane liver development lung epithelium development lymph vessel morphogenesis membrane mesonephric duct development mesonephric tubule development metanephric ascending thin limb development metanephric collecting duct development metanephric distal tubule morphogenesis metanephric proximal tubule development migrasome mitocytosis motile cilium neural tube development nucleus peptidyl-serine phosphorylation placenta blood vessel development plasma membrane polycystin complex positive regulation of cytosolic calcium ion concentration positive regulation of transcription by RNA polymerase II protein domain specific binding protein export from nucleus protein heterotetramerization protein kinase binding receptor signaling pathway via JAK-STAT regulation of G1/S transition of mitotic cell cycle regulation of cell adhesion regulation of cell cycle regulation of mitotic spindle organization regulation of proteasomal protein catabolic process response to fluid shear stress skin development spinal cord development transcription regulator inhibitor activity transmembrane transporter binding	GO:0000139 GO:0001502 GO:0001701 GO:0001822 GO:0001889 GO:0001892 GO:0002133 GO:0005262 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005886 GO:0005929 GO:0006611 GO:0006816 GO:0007156 GO:0007160 GO:0007161 GO:0007204 GO:0007259 GO:0007507 GO:0009653 GO:0009986 GO:0016020 GO:0016323 GO:0016328 GO:0018105 GO:0019901 GO:0019904 GO:0021510 GO:0021915 GO:0030155 GO:0030246 GO:0030660 GO:0031514 GO:0034405 GO:0034703 GO:0034704 GO:0036303 GO:0042813 GO:0043588 GO:0044325 GO:0045944 GO:0048565 GO:0048754 GO:0048806 GO:0050982 GO:0051216 GO:0051290 GO:0051726 GO:0060170 GO:0060236 GO:0060428 GO:0060674 GO:0061136 GO:0070062 GO:0070588 GO:0072164 GO:0072177 GO:0072205 GO:0072218 GO:0072237 GO:0072287 GO:0090162 GO:0140416 GO:0140494 GO:0160040 GO:0198738 GO:2000045
GL_000877	Polycystin-1-like protein 2	Q7Z442		Homo sapiens (human)	9606	calcium channel activity calcium ion binding carbohydrate binding detection of mechanical stimulus membrane	GO:0005262 GO:0005509 GO:0016020 GO:0030246 GO:0050982
GL_000880	Polycystin-1-like protein 3	Q7Z443		Homo sapiens (human)	9606	calcium channel activity carbohydrate binding cation channel complex cellular response to acidic pH detection of chemical stimulus involved in sensory perception of sour taste detection of mechanical stimulus extracellular exosome kidney development membrane monoatomic cation transport plasma membrane receptor complex sensory perception of sour taste	GO:0001581 GO:0001822 GO:0005262 GO:0005886 GO:0006812 GO:0016020 GO:0030246 GO:0034703 GO:0043235 GO:0050915 GO:0050982 GO:0070062 GO:0071468
GL_000883	Polypeptide N-acetylgalactosaminyltransferase 1	Q10472		Homo sapiens (human)	9606	Golgi cisterna membrane Golgi membrane O-glycan processing carbohydrate binding endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane extracellular region manganese ion binding membrane perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via serine protein O-linked glycosylation via threonine protein O-linked glycosylation viral protein processing	GO:0000139 GO:0004653 GO:0005576 GO:0005789 GO:0006493 GO:0016020 GO:0016266 GO:0018242 GO:0018243 GO:0019082 GO:0030145 GO:0030246 GO:0032580 GO:0033116 GO:0048471
GL_000888	Polypeptide N-acetylgalactosaminyltransferase 10	Q86SR1	2D7I 2D7R	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_000891	Polypeptide N-acetylgalactosaminyltransferase 11	Q8NCW6		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane Notch binding Notch receptor processing Notch signaling involved in heart development O-glycan processing carbohydrate binding cilium assembly determination of left/right symmetry metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via threonine protein O-linked glycosylation regulation of Notch signaling pathway	GO:0000139 GO:0004653 GO:0005112 GO:0005794 GO:0006493 GO:0007220 GO:0007368 GO:0008593 GO:0016266 GO:0018243 GO:0030246 GO:0046872 GO:0060271 GO:0061314
GL_000895	Polypeptide N-acetylgalactosaminyltransferase 12	Q8IXK2	6PXU	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_000897	Polypeptide N-acetylgalactosaminyltransferase 13	Q8IUC8		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via serine protein O-linked glycosylation via threonine protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0018242 GO:0018243 GO:0030246 GO:0046872
GL_000900	Polypeptide N-acetylgalactosaminyltransferase 14	Q96FL9		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_000902	Polypeptide N-acetylgalactosaminyltransferase 15	Q8N3T1		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation transport vesicle	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030133 GO:0030246 GO:0046872

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