GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **151 - 175** of **298** in total

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GlyCosmos Lectin ▲	Lectin Name	UniProt ID	PDB IDs	LfDB IDs	Monosaccharide Specificities	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID
GL_001379	BOS complex subunit NOMO3	P69849				Homo sapiens (human)	9606	carbohydrate binding determination of left/right asymmetry in lateral mesoderm endoplasmic reticulum membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane negative regulation of nodal signaling pathway ribosome binding	GO:0003140 GO:0005789 GO:0030246 GO:0043022 GO:0160063 GO:0160064 GO:1900108
GL_001380	C-type lectin domain family 4 member M Aliases: DCSIGNR CRD Fc	Q9H2X3	1K9J 1SL6 1XAR 1XPH 3JQH	LfDB0278		Homo sapiens (human)	9606	ICAM-3 receptor activity adaptive immune response antigen processing and presentation calcium-dependent protein binding carbohydrate binding cell-cell recognition cytoplasm external side of plasma membrane extracellular region fucose binding host cell immune response innate immune response intracellular signal transduction intracellular transport of virus leukocyte cell-cell adhesion mannose binding membrane metal ion binding peptide antigen binding peptide antigen transport plasma membrane receptor-mediated endocytosis of virus by host cell receptor-mediated virion attachment to host cell signaling receptor activity viral entry into host cell viral genome replication virion attachment to host cell virion binding virus receptor activity	GO:0001618 GO:0002250 GO:0005537 GO:0005576 GO:0005737 GO:0005886 GO:0006955 GO:0007159 GO:0009897 GO:0009988 GO:0016020 GO:0019062 GO:0019065 GO:0019079 GO:0019882 GO:0030246 GO:0030369 GO:0035556 GO:0038023 GO:0042605 GO:0042806 GO:0043657 GO:0045087 GO:0046718 GO:0046790 GO:0046813 GO:0046872 GO:0046968 GO:0048306 GO:0075733
GL_001382	CD209 antigen Aliases: DC-SIGN LSECtin CRD Fc	Q9NNX6	1K9I 1SL4 1SL5 2B6B 2IT5 2IT6 2XR5 2XR6 6GHV 7NL6 7NL7	LfDB0019 LfDB0277	Man	Homo sapiens (human)	9606	B cell adhesion adaptive immune response antigen processing and presentation carbohydrate binding cell surface cell-cell recognition cytoplasm endocytosis external side of plasma membrane extracellular region fucose binding heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules host cell immune response innate immune response intracellular signal transduction intracellular transport of virus leukocyte cell-cell adhesion mannose binding membrane metal ion binding peptide antigen binding peptide antigen transport plasma membrane positive regulation of T cell proliferation positive regulation of viral life cycle regulation of T cell proliferation viral entry into host cell viral genome replication virion attachment to host cell virion binding virus receptor activity	GO:0001618 GO:0002250 GO:0005537 GO:0005576 GO:0005737 GO:0005886 GO:0006897 GO:0006955 GO:0007157 GO:0007159 GO:0009897 GO:0009986 GO:0009988 GO:0016020 GO:0019062 GO:0019079 GO:0019882 GO:0030246 GO:0035556 GO:0042102 GO:0042129 GO:0042605 GO:0042806 GO:0043657 GO:0045087 GO:0046718 GO:0046790 GO:0046872 GO:0046968 GO:0075733 GO:0097323 GO:1903902
GL_001410	Collagen alpha-1(IX) chain	P20849	2UUR 5CTD 5CTI 5CVA 5CVB			Homo sapiens (human)	9606	animal organ morphogenesis carbohydrate binding collagen type IX trimer collagen-containing extracellular matrix endoplasmic reticulum lumen extracellular matrix organization extracellular matrix structural constituent conferring tensile strength extracellular region extracellular space metal ion binding protein homodimerization activity	GO:0005576 GO:0005594 GO:0005615 GO:0005788 GO:0009887 GO:0030020 GO:0030198 GO:0030246 GO:0042803 GO:0046872 GO:0062023
GL_001413	Complement C4-B	P0C0L5	6YSQ			Homo sapiens (human)	9606	axon blood microparticle carbohydrate binding complement activation, classical pathway complement activation complement binding dendrite detection of molecule of bacterial origin endopeptidase inhibitor activity extracellular exosome extracellular region extracellular space inflammatory response innate immune response opsonization plasma membrane positive regulation of apoptotic cell clearance symbiont cell surface synapse	GO:0001848 GO:0004866 GO:0005576 GO:0005615 GO:0005886 GO:0006954 GO:0006956 GO:0006958 GO:0008228 GO:0030246 GO:0030424 GO:0030425 GO:0032490 GO:0045087 GO:0045202 GO:0070062 GO:0072562 GO:0106139 GO:2000427
GL_001415	Contactin-1	Q12860	2EE2 3S97			Homo sapiens (human)	9606	Notch signaling pathway axon guidance axon brain development carbohydrate binding cell adhesion cell-cell adhesion mediator activity cell-cell adhesion central nervous system myelin formation cerebellum development extracellular exosome gene expression locomotory behavior membrane plasma membrane positive regulation of gene expression positive regulation of neuron projection development positive regulation of sodium ion transport postsynaptic membrane presynaptic membrane side of membrane	GO:0005886 GO:0007155 GO:0007219 GO:0007411 GO:0007420 GO:0007626 GO:0010467 GO:0010628 GO:0010765 GO:0010976 GO:0016020 GO:0021549 GO:0030246 GO:0030424 GO:0032289 GO:0042734 GO:0045211 GO:0070062 GO:0098552 GO:0098609 GO:0098632
GL_001459	Epididymis-specific alpha-mannosidase	Q9Y2E5				Homo sapiens (human)	9606	alpha-mannosidase activity carbohydrate binding extracellular exosome lysosomal lumen lysosome mannose metabolic process metal ion binding oligosaccharide catabolic process	GO:0004559 GO:0005764 GO:0006013 GO:0009313 GO:0030246 GO:0043202 GO:0046872 GO:0070062
GL_001465	Endoplasmic reticulum membrane protein complex subunit 7	Q9NPA0	1B0G 1LP9 2J8U 2JCC 2UWE 6WW7 6Z3W 7ADO 8EOI 8S9S			Homo sapiens (human)	9606	EMC complex carbohydrate binding endoplasmic reticulum membrane membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence tail-anchored membrane protein insertion into ER membrane	GO:0005789 GO:0016020 GO:0030246 GO:0045050 GO:0071816 GO:0072546
GL_001477	F-box only protein 6	Q9NRD1				Homo sapiens (human)	9606	DNA damage checkpoint signaling DNA repair ERAD pathway SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process carbohydrate binding cytoplasm cytosol endoplasmic reticulum quality control compartment glycoprotein catabolic process protein ubiquitination proteolysis response to unfolded protein ubiquitin protein ligase activity	GO:0000077 GO:0005737 GO:0005829 GO:0006281 GO:0006508 GO:0006516 GO:0006986 GO:0016567 GO:0019005 GO:0030246 GO:0031146 GO:0036503 GO:0044322 GO:0061630
GL_001497	Galactose mutarotase	Q96C23	1SNZ 1SO0			Homo sapiens (human)	9606	aldose 1-epimerase activity carbohydrate binding carbohydrate metabolic process cytoplasm extracellular exosome galactose catabolic process via UDP-galactose galactose metabolic process glucose metabolic process	GO:0004034 GO:0005737 GO:0005975 GO:0006006 GO:0006012 GO:0030246 GO:0033499 GO:0070062
GL_001503	Galactose-3-O-sulfotransferase 3	Q96A11				Homo sapiens (human)	9606	3'-phosphoadenosine 5'-phosphosulfate binding Golgi cisterna membrane carbohydrate binding galactose 3-O-sulfotransferase activity galactosylceramide sulfotransferase activity glycolipid biosynthetic process membrane monosaccharide metabolic process oligosaccharide metabolic process poly-N-acetyllactosamine metabolic process proteoglycan biosynthetic process proteoglycan sulfotransferase activity sulfur compound metabolic process	GO:0001733 GO:0005996 GO:0006790 GO:0009247 GO:0009311 GO:0016020 GO:0030166 GO:0030246 GO:0030309 GO:0032580 GO:0050656 GO:0050694 GO:0050698
GL_001504	GDH/6PGL endoplasmic bifunctional protein	O95479	8EM2			Homo sapiens (human)	9606	6-phosphogluconolactonase activity NADP binding carbohydrate binding endoplasmic reticulum lumen endoplasmic reticulum glucose 1-dehydrogenase (NAD+) activity glucose 1-dehydrogenase (NADP+) activity glucose 1-dehydrogenase [NAD(P)] activity glucose metabolic process glucose-6-phosphate dehydrogenase activity pentose-phosphate shunt, oxidative branch regulation of cortisol biosynthetic process response to alcohol response to nutrient levels	GO:0004345 GO:0005783 GO:0005788 GO:0006006 GO:0009051 GO:0017057 GO:0030246 GO:0031667 GO:0047934 GO:0047935 GO:0047936 GO:0050661 GO:0097305 GO:2000064
GL_001629	Glucokinase regulatory protein	Q14397	4BB9 4BBA 4LY9 4MQU 4MRO 4MSU 4OHK 4OHM 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3 4PX2 4PX3 4PX5 4PXS			Homo sapiens (human)	9606	amino sugar catabolic process carbohydrate binding carbon-oxygen lyase activity cytoplasm cytosol enzyme binding enzyme inhibitor activity ether hydrolase activity fructose-6-phosphate binding glucose homeostasis glucose sensor activity kinase inhibitor activity mitochondrion negative regulation of glucokinase activity nucleoplasm peptidoglycan turnover protein import into nucleus response to fructose response to glucose triglyceride homeostasis urate metabolic process	GO:0004857 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0006606 GO:0009254 GO:0009749 GO:0009750 GO:0016803 GO:0016835 GO:0019210 GO:0019899 GO:0030246 GO:0033132 GO:0042593 GO:0046348 GO:0046415 GO:0070095 GO:0070328 GO:0141089
GL_001648	Hematopoietic progenitor cell antigen CD34	P28906				Homo sapiens (human)	9606	RNA polymerase II-specific DNA-binding transcription factor binding apical plasma membrane basal plasma membrane carbohydrate binding cell motility cell-cell adhesion cell-matrix adhesion cytoplasm endothelial cell proliferation endothelium development external side of plasma membrane extracellular exosome assembly extracellular region glomerular endothelium development glomerular endothelium fenestra glomerular filtration hematopoietic stem cell proliferation hemopoiesis intercellular bridge leukocyte migration lysosome mesangial cell-matrix adhesion metanephric glomerular mesangial cell differentiation negative regulation of gene expression negative regulation of interleukin-2 production paracrine signaling perinuclear region of cytoplasm plasma membrane positive regulation of angiogenesis positive regulation of gene expression positive regulation of granulocyte colony-stimulating factor production positive regulation of odontogenesis positive regulation of vasculogenesis signal transduction stem cell proliferation sulfate binding tissue homeostasis transdifferentiation vascular wound healing	GO:0001894 GO:0001935 GO:0003094 GO:0003158 GO:0005576 GO:0005737 GO:0005764 GO:0005886 GO:0007160 GO:0007165 GO:0009897 GO:0009925 GO:0010628 GO:0010629 GO:0016324 GO:0030097 GO:0030246 GO:0032703 GO:0035759 GO:0036053 GO:0038001 GO:0042482 GO:0043199 GO:0045171 GO:0045766 GO:0048471 GO:0048870 GO:0050900 GO:0060290 GO:0061042 GO:0061629 GO:0071425 GO:0071657 GO:0071971 GO:0072011 GO:0072089 GO:0072254 GO:0098609 GO:2001214
GL_001664	Inter-alpha-trypsin inhibitor heavy chain H1	P19827	6FPY 6FPZ			Homo sapiens (human)	9606	blood microparticle calcium ion binding carbohydrate binding collagen-containing extracellular matrix extracellular exosome extracellular region hyaluronan metabolic process hyaluronic acid binding serine-type endopeptidase inhibitor activity	GO:0004867 GO:0005509 GO:0005540 GO:0005576 GO:0030212 GO:0030246 GO:0062023 GO:0070062 GO:0072562
GL_001666	Interleukin-2	P60568	1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E 5UTZ 6LX3 6LXW 6VWU 6YE3 7DR4 7M2G 7RA9 7RAA 7YZJ 7ZMZ			Homo sapiens (human)	9606	T cell differentiation activated T cell proliferation adaptive immune response carbohydrate binding cell adhesion cell-cell signaling cytokine activity extracellular region extracellular space extrinsic apoptotic signaling pathway in absence of ligand glycosphingolipid binding growth factor activity immune response interleukin-2 receptor binding interleukin-2-mediated signaling pathway kappa-type opioid receptor binding kinase activator activity leukocyte activation involved in immune response natural killer cell activation negative regulation of B cell apoptotic process negative regulation of T-helper 17 cell differentiation negative regulation of apoptotic process negative regulation of inflammatory response negative regulation of lymphocyte proliferation negative regulation of protein phosphorylation positive regulation of B cell proliferation positive regulation of activated T cell proliferation positive regulation of cell growth positive regulation of cell population proliferation positive regulation of cytosolic calcium ion concentration positive regulation of dendritic spine development positive regulation of immunoglobulin production positive regulation of inflammatory response positive regulation of interleukin-17 production positive regulation of isotype switching to IgG isotypes positive regulation of plasma cell differentiation positive regulation of regulatory T cell differentiation positive regulation of tissue remodeling positive regulation of transcription by RNA polymerase II positive regulation of type II interferon production positive regulation of tyrosine phosphorylation of STAT protein protein kinase C-activating G protein-coupled receptor signaling pathway regulation of CD4-positive, alpha-beta T cell proliferation regulation of T cell homeostatic proliferation response to ethanol response to tacrolimus transcription by RNA polymerase II	GO:0001933 GO:0002250 GO:0002366 GO:0002639 GO:0002903 GO:0005125 GO:0005134 GO:0005576 GO:0005615 GO:0006366 GO:0006955 GO:0007155 GO:0007204 GO:0007205 GO:0007267 GO:0008083 GO:0008284 GO:0019209 GO:0030101 GO:0030217 GO:0030246 GO:0030307 GO:0030890 GO:0031851 GO:0032729 GO:0032740 GO:0034105 GO:0038110 GO:0042104 GO:0042531 GO:0043066 GO:0043208 GO:0045471 GO:0045591 GO:0045944 GO:0046013 GO:0048304 GO:0050672 GO:0050728 GO:0050729 GO:0050798 GO:0060999 GO:0097192 GO:1900100 GO:1901327 GO:2000320 GO:2000561
GL_001669	Keratin, type II cytoskeletal 1	P04264	4ZRY 6E2J 6UUI			Homo sapiens (human)	9606	blood microparticle carbohydrate binding collagen-containing extracellular matrix complement activation, lectin pathway cornified envelope cytoplasm cytoskeleton cytosol establishment of skin barrier extracellular exosome extracellular region extracellular space fibrinolysis ficolin-1-rich granule lumen intermediate filament organization keratin filament keratinization membrane negative regulation of inflammatory response nucleus peptide cross-linking protein heterodimerization activity protein heterotetramerization regulation of angiogenesis response to oxidative stress signaling receptor activity structural constituent of skin epidermis	GO:0001533 GO:0001867 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0005856 GO:0006979 GO:0016020 GO:0018149 GO:0030246 GO:0030280 GO:0031424 GO:0038023 GO:0042730 GO:0045095 GO:0045109 GO:0045765 GO:0046982 GO:0050728 GO:0051290 GO:0061436 GO:0062023 GO:0070062 GO:0072562 GO:1904813
GL_001679	Laforin	O95278	4R30 4RKK			Homo sapiens (human)	9606	L-glutamate transmembrane transport Wnt signaling pathway autophagosome assembly calcium ion transport carbohydrate binding carbohydrate phosphatase activity carbohydrate phosphorylation cytoplasm cytoplasmic side of rough endoplasmic reticulum membrane cytosol dendrite dephosphorylation glial cell proliferation glycogen (starch) synthase activity glycogen binding glycogen biosynthetic process glycogen metabolic process habituation mitochondrion organization myosin phosphatase activity negative regulation of cell cycle negative regulation of dephosphorylation negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation negative regulation of phosphatase activity nucleoplasm nucleus peptidyl-tyrosine dephosphorylation perikaryon phosphatase activity plasma membrane positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein dephosphorylation protein dimerization activity protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity regulation of cell growth regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein ubiquitination starch binding	GO:0000045 GO:0001558 GO:0004373 GO:0004722 GO:0004725 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0005977 GO:0005978 GO:0006470 GO:0006816 GO:0007005 GO:0008138 GO:0010629 GO:0010923 GO:0014009 GO:0015813 GO:0016055 GO:0016239 GO:0016311 GO:0016791 GO:0017018 GO:0019203 GO:0030246 GO:0030425 GO:0031396 GO:0033137 GO:0035305 GO:0035335 GO:0042306 GO:0042803 GO:0043161 GO:0043204 GO:0045786 GO:0046835 GO:0046959 GO:0046983 GO:0061136 GO:0098556 GO:1903076 GO:2001069 GO:2001070
GL_001691	Lysosomal alpha-glucosidase	P10253	5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8 7P2Z 7P32			Homo sapiens (human)	9606	alpha-1,4-glucosidase activity alpha-glucosidase activity aorta development autolysosome lumen azurophil granule membrane carbohydrate binding cardiac muscle contraction diaphragm contraction extracellular exosome ficolin-1-rich granule membrane glucose metabolic process glycogen catabolic process glycophagy heart morphogenesis intracellular membrane-bounded organelle locomotory behavior lysosomal lumen lysosomal membrane lysosome organization lysosome maltose alpha-glucosidase activity maltose metabolic process membrane muscle cell cellular homeostasis neuromuscular process controlling balance neuromuscular process controlling posture plasma membrane regulation of the force of heart contraction sucrose metabolic process tertiary granule membrane tissue development vacuolar sequestering	GO:0000023 GO:0002026 GO:0002086 GO:0003007 GO:0004558 GO:0005764 GO:0005765 GO:0005886 GO:0005980 GO:0005985 GO:0006006 GO:0007040 GO:0007626 GO:0009888 GO:0016020 GO:0030246 GO:0032450 GO:0035577 GO:0035904 GO:0043181 GO:0043202 GO:0043231 GO:0046716 GO:0050884 GO:0050885 GO:0060048 GO:0061723 GO:0070062 GO:0070821 GO:0090599 GO:0101003 GO:0120282
GL_001699	Lysosomal alpha-mannosidase	O00754				Homo sapiens (human)	9606	Golgi membrane N-glycan processing alpha-mannosidase activity azurophil granule lumen carbohydrate binding extracellular exosome extracellular region extracellular space intracellular membrane-bounded organelle learning or memory lysosomal lumen lysosome mannose metabolic process metal ion binding nucleoplasm oligosaccharide catabolic process protein deglycosylation protein modification process	GO:0000139 GO:0004559 GO:0005576 GO:0005615 GO:0005654 GO:0005764 GO:0006013 GO:0006491 GO:0006517 GO:0007611 GO:0009313 GO:0030246 GO:0035578 GO:0036211 GO:0043202 GO:0043231 GO:0046872 GO:0070062
GL_001703	Malectin	Q14165	6S7T			Homo sapiens (human)	9606	carbohydrate binding endoplasmic reticulum membrane endoplasmic reticulum enzyme binding membrane oligosaccharyltransferase complex plasma membrane protein N-linked glycosylation specific granule membrane	GO:0005783 GO:0005789 GO:0005886 GO:0006487 GO:0008250 GO:0016020 GO:0019899 GO:0030246 GO:0035579
GL_001708	Maltase-glucoamylase	O43451	2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP			Homo sapiens (human)	9606	alpha-1,4-glucosidase activity amylase activity apical plasma membrane carbohydrate binding catalytic activity dextrin catabolic process extracellular exosome ficolin-1-rich granule membrane glucan 1,4-alpha-glucosidase activity maltose alpha-glucosidase activity maltose catabolic process plasma membrane starch catabolic process tertiary granule membrane	GO:0000025 GO:0003824 GO:0004339 GO:0004558 GO:0005886 GO:0005983 GO:0016160 GO:0016324 GO:0030246 GO:0032450 GO:0070062 GO:0070821 GO:0101003 GO:1901027
GL_001720	Nectin-1	Q15223	3ALP 3SKU 3U82 3U83 4FMF 4MYW			Homo sapiens (human)	9606	adherens junction apical junction complex axon guidance carbohydrate binding cell adhesion molecule binding cell adhesion cell-cell adhesion cell-cell contact zone coreceptor activity dendrite desmosome organization enamel mineralization extracellular region growth cone membrane heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules hippocampal mossy fiber to CA3 synapse homophilic cell adhesion via plasma membrane adhesion molecules identical protein binding immune response iron ion transport lens morphogenesis in camera-type eye membrane plasma membrane presynaptic active zone membrane protein homodimerization activity protein localization to cell junction protein-containing complex binding regulation of synapse assembly retina development in camera-type eye viral entry into host cell virion binding virus receptor activity	GO:0001618 GO:0002089 GO:0002934 GO:0005576 GO:0005886 GO:0005912 GO:0006826 GO:0006955 GO:0007155 GO:0007156 GO:0007157 GO:0007411 GO:0015026 GO:0016020 GO:0030246 GO:0030425 GO:0032584 GO:0042802 GO:0042803 GO:0043296 GO:0044291 GO:0044877 GO:0046718 GO:0046790 GO:0048787 GO:0050839 GO:0051963 GO:0060041 GO:0070166 GO:0098609 GO:0098686 GO:1902414
GL_001725	Neutral alpha-glucosidase AB	Q14697	8D43 8EMR			Homo sapiens (human)	9606	Golgi apparatus N-glycan processing RNA binding alpha-glucosidase activity carbohydrate binding carbohydrate metabolic process endoplasmic reticulum lumen extracellular exosome glucan 1,3-alpha-glucosidase activity glucosidase II complex intracellular membrane-bounded organelle melanosome membrane	GO:0003723 GO:0005788 GO:0005794 GO:0005975 GO:0006491 GO:0016020 GO:0017177 GO:0030246 GO:0033919 GO:0042470 GO:0043231 GO:0070062 GO:0090599
GL_001728	Neutral alpha-glucosidase C	Q8TET4				Homo sapiens (human)	9606	N-glycan processing alpha-1,4-glucosidase activity carbohydrate binding maltose alpha-glucosidase activity	GO:0004558 GO:0006491 GO:0030246 GO:0032450

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