GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	March 3, 2025
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **1 - 25** of **297** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology ▲	Gene Ontology ID
GL_000197	C-type lectin domain family 7 member A	Q9BXN2		Homo sapiens (human)	9606	(1->3)-beta-D-glucan binding MHC protein binding T cell activation antifungal innate immune response carbohydrate binding carbohydrate mediated signaling cell activation cell recognition cell surface cellular response to molecule of fungal origin cytoplasm defense response to protozoan detection of fungus detection of molecule of fungal origin detection of yeast identical protein binding inflammatory response innate immune response membrane metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of T-helper 17 type immune response positive regulation of calcium-mediated signaling positive regulation of canonical NF-kappaB signal transduction positive regulation of cell maturation positive regulation of cell migration positive regulation of cell population proliferation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cytokine production involved in immune response positive regulation of cytokine production involved in inflammatory response positive regulation of dendritic cell cytokine production positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of killing of cells of another organism positive regulation of lymphocyte activation positive regulation of monocyte chemotactic protein-1 production positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis positive regulation of protein-containing complex assembly positive regulation of respiratory burst positive regulation of superoxide anion generation positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of wound healing regulation of calcineurin-NFAT signaling cascade regulation of canonical NF-kappaB signal transduction response to yeast stimulatory C-type lectin receptor signaling pathway	GO:0001775 GO:0001872 GO:0001878 GO:0001879 GO:0002223 GO:0002720 GO:0002732 GO:0005737 GO:0005886 GO:0006910 GO:0006954 GO:0008037 GO:0008284 GO:0009756 GO:0009986 GO:0010628 GO:0016020 GO:0016046 GO:0030246 GO:0030335 GO:0031334 GO:0032491 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032743 GO:0032747 GO:0032755 GO:0032757 GO:0032760 GO:0032930 GO:0038187 GO:0042110 GO:0042287 GO:0042802 GO:0042832 GO:0043122 GO:0043123 GO:0043280 GO:0045087 GO:0045429 GO:0046872 GO:0050766 GO:0050850 GO:0051091 GO:0051092 GO:0051251 GO:0051712 GO:0060267 GO:0061760 GO:0070884 GO:0071226 GO:0071639 GO:0090303 GO:1900017 GO:1903431 GO:2000318
GL_002359	Pentraxin-related protein PTX3	P26022	7ZL1 8PVQ	Homo sapiens (human)	9606	(1->3)-beta-D-glucan binding complement component C1q complex binding extracellular matrix organization extracellular matrix extracellular region extracellular space identical protein binding inflammatory response innate immune response negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process negative regulation by host of viral process negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process negative regulation of viral entry into host cell opsonization ovarian cumulus expansion positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis response to yeast specific granule lumen tertiary granule lumen virion binding	GO:0001550 GO:0001849 GO:0001872 GO:0001878 GO:0005576 GO:0005615 GO:0006954 GO:0008228 GO:0030198 GO:0031012 GO:0035580 GO:0042802 GO:0044793 GO:0044869 GO:0044871 GO:0045087 GO:0045429 GO:0046597 GO:0046790 GO:0050766 GO:1903016 GO:1903019 GO:1904724
GL_001835	Sorbitol dehydrogenase	Q00796	1PL6 1PL7 1PL8	Homo sapiens (human)	9606	(R,R)-butanediol dehydrogenase activity D-sorbitol dehydrogenase (acceptor) activity D-xylulose reductase activity L-iditol 2-dehydrogenase activity L-xylitol catabolic process L-xylitol metabolic process NAD binding carbohydrate binding cytosol extracellular exosome extracellular space flagellated sperm motility fructose biosynthetic process glucose metabolic process glucuronate catabolic process to xylulose 5-phosphate identical protein binding membrane mitochondrial membrane motile cilium ribitol 2-dehydrogenase activity sorbitol catabolic process zinc ion binding	GO:0000721 GO:0003939 GO:0005615 GO:0005829 GO:0006006 GO:0006062 GO:0008270 GO:0016020 GO:0019640 GO:0030246 GO:0030317 GO:0031514 GO:0031966 GO:0042802 GO:0046370 GO:0046526 GO:0047833 GO:0050255 GO:0051160 GO:0051164 GO:0051287 GO:0070062
GL_001183	1,4-alpha-glucan-branching enzyme	Q04446	4BZY 5CLT 5CLW	Homo sapiens (human)	9606	1,4-alpha-glucan branching enzyme activity carbohydrate binding cation binding cytoplasm cytosol extracellular exosome generation of precursor metabolites and energy glycogen biosynthetic process glycogen metabolic process hydrolase activity, hydrolyzing O-glycosyl compounds negative regulation of neuron apoptotic process	GO:0003844 GO:0004553 GO:0005737 GO:0005829 GO:0005977 GO:0005978 GO:0006091 GO:0030246 GO:0043169 GO:0043524 GO:0070062
GL_005069	Phytanoyl-CoA dioxygenase, peroxisomal	O14832	2A1X	Homo sapiens (human)	9606	2-oxobutyrate catabolic process 2-oxoglutarate metabolic process 9+0 non-motile cilium L-ascorbic acid binding carboxylic acid binding cytosol fatty acid alpha-oxidation ferrous iron binding isoprenoid metabolic process methyl-branched fatty acid metabolic process peroxisomal matrix peroxisome phytanoyl-CoA dioxygenase activity	GO:0001561 GO:0005777 GO:0005782 GO:0005829 GO:0006103 GO:0006720 GO:0008198 GO:0019606 GO:0031406 GO:0031418 GO:0048244 GO:0097089 GO:0097731
GL_005250	Prolyl hydroxylase EGLN3	Q9H6Z9		Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity DNA damage response L-ascorbic acid binding activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process cellular response to hypoxia cytoplasm cytosol ferrous iron binding hypoxia-inducible factor-proline dioxygenase activity nucleoplasm nucleus peptidyl-proline 4-dioxygenase activity protein hydroxylation regulation of cell population proliferation regulation of neuron apoptotic process response to hypoxia	GO:0001666 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0006974 GO:0008198 GO:0016706 GO:0018126 GO:0031418 GO:0031545 GO:0042127 GO:0043523 GO:0071456 GO:0160082
GL_005117	Transmembrane prolyl 4-hydroxylase	Q9NXG6	6TP5	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding calcium ion binding endoplasmic reticulum membrane endoplasmic reticulum hypoxia-inducible factor-proline dioxygenase activity iron ion binding procollagen-proline 4-dioxygenase activity regulation of erythrocyte differentiation	GO:0004656 GO:0005506 GO:0005509 GO:0005783 GO:0005789 GO:0016706 GO:0031418 GO:0045646 GO:0160082
GL_004978	Egl nine homolog 1	Q9GZT9	2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT 6YVW 6YVX 6YVZ 6YW0 6YW1 6YW2 6YW3 6YW4 6ZBN 6ZBO 7Q5V 7Q5X 7UJV 7UMP 8J1K 8Q5S 8Q64 8Q6D 8Q6E	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding cardiac muscle tissue morphogenesis cellular response to hypoxia cytoplasm cytosol enzyme binding ferrous iron binding glutamatergic synapse heart trabecula formation hypoxia-inducible factor-proline dioxygenase activity intracellular iron ion homeostasis intracellular membrane-bounded organelle intracellular oxygen homeostasis labyrinthine layer development negative regulation of DNA-binding transcription factor activity negative regulation of cyclic-nucleotide phosphodiesterase activity nucleus peptidyl-proline 4-dioxygenase activity peptidyl-proline dioxygenase activity positive regulation of transcription by RNA polymerase II postsynaptic density regulation of angiogenesis regulation of modification of postsynaptic structure regulation protein catabolic process at postsynapse response to hypoxia response to nitric oxide ventricular septum morphogenesis	GO:0001666 GO:0005634 GO:0005737 GO:0005829 GO:0006879 GO:0008198 GO:0014069 GO:0016706 GO:0019899 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043231 GO:0043433 GO:0045765 GO:0045944 GO:0051344 GO:0055008 GO:0060347 GO:0060412 GO:0060711 GO:0071456 GO:0071731 GO:0098978 GO:0099159 GO:0140252 GO:0160082
GL_005016	Prolyl hydroxylase EGLN2	Q96KS0	5V1B	Homo sapiens (human)	9606	2-oxoglutarate-dependent dioxygenase activity L-ascorbic acid binding cell redox homeostasis cellular response to hypoxia cytoplasm ferrous iron binding hypoxia-inducible factor-proline dioxygenase activity intracellular estrogen receptor signaling pathway nucleoplasm nucleus oxygen sensor activity peptidyl-proline 4-dioxygenase activity peptidyl-proline hydroxylation to 4-hydroxy-L-proline positive regulation of protein catabolic process regulation of cell growth regulation of neuron apoptotic process response to hypoxia	GO:0001558 GO:0001666 GO:0005634 GO:0005654 GO:0005737 GO:0008198 GO:0016706 GO:0018401 GO:0019826 GO:0030520 GO:0031418 GO:0031545 GO:0043523 GO:0045454 GO:0045732 GO:0071456 GO:0160082
GL_002835	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	P22413	2YS0 6WET 6WEU 6WEV 6WEW 6WFJ 8GHR	Homo sapiens (human)	9606	3',5'-cyclic-AMP phosphodiesterase activity 3'-phosphoadenosine 5'-phosphosulfate binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process ATP binding ATP diphosphatase activity ATP metabolic process GTP diphosphatase activity UTP diphosphatase activity basolateral plasma membrane bone mineralization calcium ion binding cell surface cellular response to insulin stimulus cyclic-GMP-AMP hydrolase activity dinucleotide phosphatase activity exonuclease activity extracellular space gene expression generation of precursor metabolites and energy immune response inorganic diphosphate transport insulin receptor binding intracellular phosphate ion homeostasis lysosomal membrane melanocyte differentiation membrane negative regulation of bone mineralization negative regulation of cell growth negative regulation of fat cell differentiation negative regulation of glucose import negative regulation of glycogen biosynthetic process negative regulation of hh target transcription factor activity negative regulation of insulin receptor signaling pathway negative regulation of protein autophosphorylation nucleic acid binding nucleic acid metabolic process nucleoside triphosphate catabolic process nucleoside triphosphate diphosphatase activity phosphatase activity phosphate ion homeostasis phosphate-containing compound metabolic process phosphodiesterase I activity plasma membrane polysaccharide binding protein homodimerization activity regulation of bone mineralization response to ATP scavenger receptor activity sequestering of triglyceride zinc ion binding	GO:0003676 GO:0004115 GO:0004527 GO:0004528 GO:0004551 GO:0005044 GO:0005158 GO:0005509 GO:0005524 GO:0005615 GO:0005765 GO:0005886 GO:0006091 GO:0006796 GO:0006955 GO:0008270 GO:0009143 GO:0009986 GO:0010467 GO:0016020 GO:0016323 GO:0016791 GO:0030247 GO:0030282 GO:0030308 GO:0030318 GO:0030500 GO:0030502 GO:0030505 GO:0030643 GO:0030730 GO:0031953 GO:0032869 GO:0033198 GO:0036219 GO:0036221 GO:0042803 GO:0045599 GO:0045719 GO:0046034 GO:0046325 GO:0046627 GO:0047429 GO:0047693 GO:0050427 GO:0050656 GO:0055062 GO:0090304 GO:0106177 GO:1990787
GL_001503	Galactose-3-O-sulfotransferase 3	Q96A11		Homo sapiens (human)	9606	3'-phosphoadenosine 5'-phosphosulfate binding Golgi cisterna membrane carbohydrate binding galactose 3-O-sulfotransferase activity galactosylceramide sulfotransferase activity glycolipid biosynthetic process membrane monosaccharide metabolic process oligosaccharide metabolic process poly-N-acetyllactosamine metabolic process proteoglycan biosynthetic process proteoglycan sulfotransferase activity sulfur compound metabolic process	GO:0001733 GO:0005996 GO:0006790 GO:0009247 GO:0009311 GO:0016020 GO:0030166 GO:0030246 GO:0030309 GO:0032580 GO:0050656 GO:0050694 GO:0050698
GL_002763	Glycogen debranching enzyme	P35573		Homo sapiens (human)	9606	4-alpha-glucanotransferase activity amylo-alpha-1,6-glucosidase activity cytoplasm cytosol extracellular region ficolin-1-rich granule lumen glycogen biosynthetic process glycogen catabolic process glycogen debranching enzyme activity inclusion body isoamylase complex nucleus polysaccharide binding polyubiquitin modification-dependent protein binding response to glucocorticoid response to nutrient sarcoplasmic reticulum secretory granule lumen	GO:0004133 GO:0004134 GO:0004135 GO:0005576 GO:0005634 GO:0005737 GO:0005829 GO:0005978 GO:0005980 GO:0007584 GO:0016234 GO:0016529 GO:0030247 GO:0031593 GO:0034774 GO:0043033 GO:0051384 GO:1904813
GL_002529	Glycogen phosphorylase, liver form	P06737	1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW 8EMS	Homo sapiens (human)	9606	5-phosphoribose 1-diphosphate biosynthetic process AMP binding ATP binding SHG alpha-glucan phosphorylase activity bile acid binding cytoplasm cytosol extracellular exosome extracellular region ficolin-1-rich granule lumen glucose binding glucose homeostasis glycogen catabolic process glycogen metabolic process glycogen phosphorylase activity identical protein binding linear malto-oligosaccharide phosphorylase activity necroptotic process purine nucleobase binding pyridoxal phosphate binding response to bacterium secretory granule lumen vitamin binding	GO:0002060 GO:0005524 GO:0005536 GO:0005576 GO:0005737 GO:0005829 GO:0005977 GO:0005980 GO:0006015 GO:0008184 GO:0009617 GO:0016208 GO:0019842 GO:0030170 GO:0032052 GO:0034774 GO:0042593 GO:0042802 GO:0070062 GO:0070266 GO:0102250 GO:0102499 GO:1904813
GL_003892	ATP-dependent 6-phosphofructokinase, muscle type	P08237	4OMT	Homo sapiens (human)	9606	6-phosphofructokinase activity 6-phosphofructokinase complex AMP binding ATP binding apical plasma membrane canonical glycolysis cytosol fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose binding fructose-6-phosphate binding glucose homeostasis glycogen catabolic process glycolysis from storage polysaccharide through glucose-1-phosphate glycolytic process through fructose-6-phosphate glycolytic process identical protein binding kinase binding membrane metal ion binding monosaccharide binding muscle cell cellular homeostasis nucleus positive regulation of insulin secretion positive regulation of transcription by RNA polymerase II sperm principal piece	GO:0003872 GO:0005524 GO:0005634 GO:0005829 GO:0005945 GO:0005980 GO:0006002 GO:0006096 GO:0016020 GO:0016208 GO:0016324 GO:0019900 GO:0030388 GO:0032024 GO:0042593 GO:0042802 GO:0045944 GO:0046716 GO:0046872 GO:0048029 GO:0061615 GO:0061621 GO:0070061 GO:0070095 GO:0093001 GO:0097228
GL_003956	ATP-dependent 6-phosphofructokinase, platelet type	Q01813	4RH3 4U1R 4WL0 4XYJ 4XYK 4XZ2 7TFF	Homo sapiens (human)	9606	6-phosphofructokinase activity 6-phosphofructokinase complex AMP binding ATP binding cadherin binding canonical glycolysis cellular response to leukemia inhibitory factor cytoplasm cytosol extracellular exosome fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose-6-phosphate binding identical protein binding membrane metal ion binding monosaccharide binding nucleus protein-containing complex binding	GO:0003872 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0005945 GO:0006002 GO:0016020 GO:0016208 GO:0030388 GO:0042802 GO:0044877 GO:0045296 GO:0046872 GO:0048029 GO:0061621 GO:0070062 GO:0070095 GO:1990830
GL_003651	ATP-dependent 6-phosphofructokinase, liver type	P17858	7LW1	Homo sapiens (human)	9606	6-phosphofructokinase activity 6-phosphofructokinase complex AMP binding ATP binding canonical glycolysis cytosol extracellular exosome extracellular region ficolin-1-rich granule lumen fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose binding fructose-6-phosphate binding glycolytic process identical protein binding kinase binding membrane metal ion binding monosaccharide binding negative regulation of insulin secretion response to glucose secretory granule lumen	GO:0003872 GO:0005524 GO:0005576 GO:0005829 GO:0005945 GO:0006002 GO:0006096 GO:0009749 GO:0016020 GO:0016208 GO:0019900 GO:0030388 GO:0034774 GO:0042802 GO:0046676 GO:0046872 GO:0048029 GO:0061621 GO:0070061 GO:0070062 GO:0070095 GO:1904813
GL_001504	GDH/6PGL endoplasmic bifunctional protein	O95479	8EM2	Homo sapiens (human)	9606	6-phosphogluconolactonase activity NADP binding carbohydrate binding endoplasmic reticulum lumen endoplasmic reticulum glucose 1-dehydrogenase (NAD+) activity glucose 1-dehydrogenase (NADP+) activity glucose metabolic process glucose-6-phosphate dehydrogenase activity pentose-phosphate shunt, oxidative branch regulation of cortisol biosynthetic process response to alcohol response to nutrient levels	GO:0004345 GO:0005783 GO:0005788 GO:0006006 GO:0009051 GO:0017057 GO:0030246 GO:0031667 GO:0047934 GO:0047935 GO:0050661 GO:0097305 GO:2000064
GL_003393	Fructose-1,6-bisphosphatase 1	P09467	1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 6LS5 6LW2 7C9Q 7CVH 7CVN 7CWE 7EZF 7EZP 7EZR 7WJV 7WVB	Homo sapiens (human)	9606	AMP binding RNA polymerase II-specific DNA-binding transcription factor binding cellular hyperosmotic salinity response cellular hypotonic salinity response cellular response to cAMP cellular response to insulin stimulus cellular response to magnesium ion cellular response to phorbol 13-acetate 12-myristate cellular response to raffinose cellular response to xenobiotic stimulus cytoplasm cytosol dephosphorylation extracellular exosome fructose 1,6-bisphosphate 1-phosphatase activity fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose metabolic process gluconeogenesis identical protein binding metal ion binding monosaccharide binding negative regulation of Ras protein signal transduction negative regulation of cell growth negative regulation of glycolytic process negative regulation of transcription by RNA polymerase II nucleus regulation of gluconeogenesis response to nutrient levels sucrose biosynthetic process	GO:0000122 GO:0005634 GO:0005737 GO:0005829 GO:0005986 GO:0006000 GO:0006002 GO:0006094 GO:0006111 GO:0016208 GO:0016311 GO:0030308 GO:0030388 GO:0031667 GO:0032869 GO:0042132 GO:0042802 GO:0045820 GO:0046580 GO:0046872 GO:0048029 GO:0061629 GO:0070062 GO:0071286 GO:0071320 GO:0071466 GO:0071475 GO:0071477 GO:0097403 GO:1904628
GL_002536	Hexokinase-1	P19367	1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB	Homo sapiens (human)	9606	ATP binding GDP-mannose biosynthetic process from mannose GDP-mannose biosynthetic process canonical glycolysis carbohydrate phosphorylation cytosol establishment of protein localization to mitochondrion fructokinase activity fructose 6-phosphate metabolic process glucokinase activity glucosamine kinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process hexokinase activity inflammatory response innate immune response intracellular glucose homeostasis maintenance of protein location in mitochondrion mannokinase activity mannose metabolic process membrane raft mitochondrial outer membrane mitochondrion peptidoglycan binding positive regulation of cytokine production involved in immune response positive regulation of interleukin-1 beta production	GO:0001678 GO:0002720 GO:0004340 GO:0004396 GO:0005524 GO:0005536 GO:0005739 GO:0005741 GO:0005829 GO:0006002 GO:0006006 GO:0006013 GO:0006096 GO:0006954 GO:0008865 GO:0009298 GO:0019158 GO:0032731 GO:0042834 GO:0045087 GO:0045121 GO:0046835 GO:0047931 GO:0051156 GO:0061621 GO:0061728 GO:0072655 GO:0072656
GL_002596	Hexokinase-4	P35557	1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I 7T78 7T79	Homo sapiens (human)	9606	ATP binding NADP metabolic process calcium ion import canonical glycolysis carbohydrate phosphorylation cellular response to insulin stimulus cellular response to leptin stimulus cytosol fructokinase activity glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose catabolic process glucose homeostasis glucose metabolic process glucose sensor activity glycolytic process intracellular glucose homeostasis mannokinase activity mitochondrion negative regulation of gluconeogenesis nucleoplasm positive regulation of glycogen biosynthetic process positive regulation of insulin secretion regulation of glycolytic process regulation of insulin secretion regulation of potassium ion transport response to glucose	GO:0001678 GO:0004340 GO:0005524 GO:0005536 GO:0005654 GO:0005739 GO:0005829 GO:0006006 GO:0006007 GO:0006096 GO:0006110 GO:0006739 GO:0008865 GO:0009749 GO:0019158 GO:0032024 GO:0032869 GO:0042593 GO:0043266 GO:0044320 GO:0045721 GO:0045725 GO:0046835 GO:0050796 GO:0051156 GO:0061621 GO:0070509 GO:0141089
GL_002600	Hexokinase-2	P52789	2NZT 5HEX 5HFU 5HG1	Homo sapiens (human)	9606	ATP binding apoptotic mitochondrial changes canonical glycolysis carbohydrate phosphorylation cellular response to leukemia inhibitory factor centrosome cytosol establishment of protein localization to mitochondrion fructokinase activity fructose 6-phosphate metabolic process glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process hexokinase activity intracellular glucose homeostasis intracellular membrane-bounded organelle lactation maintenance of protein location in mitochondrion membrane mitochondrial outer membrane mitochondrion negative regulation of mitochondrial membrane permeability negative regulation of reactive oxygen species metabolic process positive regulation of angiogenesis positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization regulation of glucose import response to hypoxia response to ischemia sarcoplasmic reticulum	GO:0001666 GO:0001678 GO:0002931 GO:0004340 GO:0004396 GO:0005524 GO:0005536 GO:0005739 GO:0005741 GO:0005813 GO:0005829 GO:0006002 GO:0006006 GO:0006096 GO:0007595 GO:0008637 GO:0008865 GO:0016020 GO:0016529 GO:0035795 GO:0043231 GO:0045766 GO:0046324 GO:0046835 GO:0051156 GO:0061621 GO:0072655 GO:0072656 GO:1904925 GO:1990830 GO:2000378
GL_002481	Hexokinase-3	P52790	3HM8	Homo sapiens (human)	9606	ATP binding canonical glycolysis carbohydrate phosphorylation cytosol extracellular region ficolin-1-rich granule lumen fructokinase activity fructose 6-phosphate metabolic process glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process hexokinase activity intracellular glucose homeostasis mitochondrion secretory granule lumen	GO:0001678 GO:0004340 GO:0004396 GO:0005524 GO:0005536 GO:0005576 GO:0005739 GO:0005829 GO:0006002 GO:0006006 GO:0006096 GO:0008865 GO:0034774 GO:0046835 GO:0051156 GO:0061621 GO:1904813
GL_002486	Hexokinase HKDC1	Q2TB90		Homo sapiens (human)	9606	ATP binding carbohydrate phosphorylation cytoplasm cytosol fructokinase activity glucokinase activity glucose 6-phosphate metabolic process glucose binding glucose metabolic process glycolytic process intracellular glucose homeostasis mitochondrial membrane mitochondrion photoreceptor inner segment	GO:0001678 GO:0001917 GO:0004340 GO:0005524 GO:0005536 GO:0005737 GO:0005739 GO:0005829 GO:0006006 GO:0006096 GO:0008865 GO:0031966 GO:0046835 GO:0051156
GL_003353	Pyruvate kinase PKLR	P30613	2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 5SC8 5SC9 5SCA 5SCB 5SCC 5SCD 5SCE 5SCF 5SCG 5SCH 5SCI 5SCJ 5SCK 5SCL 5SDT 6NN4 6NN5 6NN7 6NN8 7FRV 7FRW 7FRX 7FRY 7FRZ 7FS0 7FS1 7FS2 7FS3 7FS4 7FS5 7FS6 7FS7 7FS8 7FS9 7FSA 7FSB 7FSC 7FSD 7QDN 7QZU 8TBS 8TBT 8TBU 8XFD	Homo sapiens (human)	9606	ATP binding cellular response to epinephrine stimulus cellular response to insulin stimulus cytoplasm cytosol extracellular exosome glycolytic process kinase activity magnesium ion binding monosaccharide binding phosphorylation potassium ion binding pyruvate biosynthetic process pyruvate kinase activity pyruvate kinase complex response to ATP response to cAMP response to glucose response to hypoxia response to metal ion response to nutrient	GO:0000287 GO:0001666 GO:0004743 GO:0005524 GO:0005737 GO:0005829 GO:0006096 GO:0007584 GO:0009749 GO:0010038 GO:0016301 GO:0016310 GO:0030955 GO:0032869 GO:0033198 GO:0042866 GO:0048029 GO:0051591 GO:0070062 GO:0071872 GO:1902912
GL_003444	Alpha-protein kinase 1	Q96QP1	5Z2C	Homo sapiens (human)	9606	ATP binding centrosome cilium assembly cilium cytoplasmic pattern recognition receptor signaling pathway cytosol histone H2AS1 kinase activity innate immune response monosaccharide binding positive regulation of canonical NF-kappaB signal transduction protein phosphorylation protein serine kinase activity protein serine/threonine kinase activity spindle pole	GO:0000922 GO:0002753 GO:0004674 GO:0005524 GO:0005813 GO:0005829 GO:0005929 GO:0006468 GO:0043123 GO:0044024 GO:0045087 GO:0048029 GO:0060271 GO:0106310

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