GlyCosmos Portal

GlyCosmos Lectins

Integrated list of Lectins, including proteins with carbohydrate binding function obtained from UniProt and lectin data from Lectin Frontier DataBase (LfDB), UniLectin and CarboGrove. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Source	Last Updated
MCAW	July 10, 2019
UniLectin	June 14, 2023
UniProt	June 6, 2024
Lectin Frontier DataBase (LfDB)	April 6, 2018
CarboGrove	June 14, 2023

Displaying entries **1 - 25** of **298** in total

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GlyCosmos Lectin	Lectin Name	UniProt ID	PDB IDs	Organism	Taxonomy ID	Gene Ontology	Gene Ontology ID ▲
GL_001691	Lysosomal alpha-glucosidase	P10253	5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8 7P2Z 7P32	Homo sapiens (human)	9606	alpha-1,4-glucosidase activity alpha-glucosidase activity aorta development autolysosome lumen azurophil granule membrane carbohydrate binding cardiac muscle contraction diaphragm contraction extracellular exosome ficolin-1-rich granule membrane glucose metabolic process glycogen catabolic process glycophagy heart morphogenesis intracellular membrane-bounded organelle locomotory behavior lysosomal lumen lysosomal membrane lysosome organization lysosome maltose alpha-glucosidase activity maltose metabolic process membrane muscle cell cellular homeostasis neuromuscular process controlling balance neuromuscular process controlling posture plasma membrane regulation of the force of heart contraction sucrose metabolic process tertiary granule membrane tissue development vacuolar sequestering	GO:0000023 GO:0002026 GO:0002086 GO:0003007 GO:0004558 GO:0005764 GO:0005765 GO:0005886 GO:0005980 GO:0005985 GO:0006006 GO:0007040 GO:0007626 GO:0009888 GO:0016020 GO:0030246 GO:0032450 GO:0035577 GO:0035904 GO:0043181 GO:0043202 GO:0043231 GO:0046716 GO:0050884 GO:0050885 GO:0060048 GO:0061723 GO:0070062 GO:0070821 GO:0090599 GO:0101003 GO:0120282
GL_001708	Maltase-glucoamylase	O43451	2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP	Homo sapiens (human)	9606	alpha-1,4-glucosidase activity amylase activity apical plasma membrane carbohydrate binding catalytic activity dextrin catabolic process extracellular exosome ficolin-1-rich granule membrane glucan 1,4-alpha-glucosidase activity maltose alpha-glucosidase activity maltose catabolic process plasma membrane starch catabolic process tertiary granule membrane	GO:0000025 GO:0003824 GO:0004339 GO:0004558 GO:0005886 GO:0005983 GO:0016160 GO:0016324 GO:0030246 GO:0032450 GO:0070062 GO:0070821 GO:0101003 GO:1901027
GL_001679	Laforin	O95278	4R30 4RKK	Homo sapiens (human)	9606	L-glutamate transmembrane transport Wnt signaling pathway autophagosome assembly calcium ion transport carbohydrate binding carbohydrate phosphatase activity carbohydrate phosphorylation cytoplasm cytoplasmic side of rough endoplasmic reticulum membrane cytosol dendrite dephosphorylation glial cell proliferation glycogen (starch) synthase activity glycogen binding glycogen biosynthetic process glycogen metabolic process habituation mitochondrion organization myosin phosphatase activity negative regulation of cell cycle negative regulation of dephosphorylation negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation negative regulation of phosphatase activity nucleoplasm nucleus peptidyl-tyrosine dephosphorylation perikaryon phosphatase activity plasma membrane positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein dephosphorylation protein dimerization activity protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity regulation of cell growth regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein ubiquitination starch binding	GO:0000045 GO:0001558 GO:0004373 GO:0004722 GO:0004725 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0005977 GO:0005978 GO:0006470 GO:0006816 GO:0007005 GO:0008138 GO:0010629 GO:0010923 GO:0014009 GO:0015813 GO:0016055 GO:0016239 GO:0016311 GO:0016791 GO:0017018 GO:0019203 GO:0030246 GO:0030425 GO:0031396 GO:0033137 GO:0035305 GO:0035335 GO:0042306 GO:0042803 GO:0043161 GO:0043204 GO:0045786 GO:0046835 GO:0046959 GO:0046983 GO:0061136 GO:0098556 GO:1903076 GO:2001069 GO:2001070
GL_001477	F-box only protein 6	Q9NRD1		Homo sapiens (human)	9606	DNA damage checkpoint signaling DNA repair ERAD pathway SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process carbohydrate binding cytoplasm cytosol endoplasmic reticulum quality control compartment glycoprotein catabolic process protein ubiquitination proteolysis response to unfolded protein ubiquitin protein ligase activity	GO:0000077 GO:0005737 GO:0005829 GO:0006281 GO:0006508 GO:0006516 GO:0006986 GO:0016567 GO:0019005 GO:0030246 GO:0031146 GO:0036503 GO:0044322 GO:0061630
GL_003128	Lysyl oxidase homolog 2	Q9Y4K0	5ZE3	Homo sapiens (human)	9606	basement membrane calcium ion binding chromatin collagen fibril organization collagen-containing extracellular matrix copper ion binding endoplasmic reticulum endothelial cell migration endothelial cell proliferation epithelial to mesenchymal transition extracellular space heterochromatin organization membrane negative regulation of DNA-templated transcription negative regulation of stem cell population maintenance negative regulation of transcription by RNA polymerase II nucleoplasm nucleus oligosaccharide binding peptidyl-lysine oxidation positive regulation of chondrocyte differentiation positive regulation of epithelial to mesenchymal transition protein modification process protein-lysine 6-oxidase activity response to copper ion response to hypoxia sprouting angiogenesis	GO:0000122 GO:0000785 GO:0001666 GO:0001837 GO:0001935 GO:0002040 GO:0004720 GO:0005507 GO:0005509 GO:0005604 GO:0005615 GO:0005634 GO:0005654 GO:0005783 GO:0010718 GO:0016020 GO:0018057 GO:0030199 GO:0032332 GO:0036211 GO:0043542 GO:0045892 GO:0046688 GO:0062023 GO:0070492 GO:0070828 GO:1902455
GL_002455	Endoglin	P17813	5HZV 5HZW 5I04	Homo sapiens (human)	9606	BMP signaling pathway activin binding artery morphogenesis atrial cardiac muscle tissue morphogenesis atrioventricular canal morphogenesis bone development branching involved in blood vessel morphogenesis cardiac atrium morphogenesis cardiac ventricle morphogenesis cell adhesion cell chemotaxis cell migration involved in endocardial cushion formation cell migration cell motility cell surface cellular response to mechanical stimulus central nervous system vasculogenesis coreceptor activity detection of hypoxia dorsal aorta morphogenesis endocardial cushion morphogenesis endothelial microparticle epithelial to mesenchymal transition involved in endocardial cushion formation epithelial to mesenchymal transition external side of plasma membrane extracellular matrix constituent secretion extracellular matrix disassembly extracellular space focal adhesion galactose binding glycosaminoglycan binding heart looping identical protein binding negative regulation of cell migration negative regulation of endothelial cell proliferation negative regulation of gene expression negative regulation of nitric-oxide synthase activity negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway nuclear body outflow tract septum morphogenesis plasma membrane positive regulation of BMP signaling pathway positive regulation of SMAD protein signal transduction positive regulation of angiogenesis positive regulation of collagen biosynthetic process positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of gene expression positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of protein phosphorylation positive regulation of systemic arterial blood pressure positive regulation of transcription by RNA polymerase II positive regulation of vascular associated smooth muscle cell differentiation protein homodimerization activity receptor complex regulation of DNA-templated transcription regulation of cell adhesion regulation of cell population proliferation regulation of phosphorylation regulation of transforming growth factor beta receptor signaling pathway response to hypoxia response to xenobiotic stimulus signaling receptor activator activity smooth muscle tissue development transforming growth factor beta binding transforming growth factor beta receptor activity transforming growth factor beta receptor signaling pathway transmembrane signaling receptor activity type I transforming growth factor beta receptor binding type II transforming growth factor beta receptor binding vascular associated smooth muscle cell development vasculogenesis venous blood vessel morphogenesis ventricular trabecula myocardium morphogenesis wound healing	GO:0000122 GO:0001569 GO:0001570 GO:0001666 GO:0001837 GO:0001934 GO:0001937 GO:0001947 GO:0003084 GO:0003148 GO:0003198 GO:0003203 GO:0003208 GO:0003209 GO:0003222 GO:0003273 GO:0004888 GO:0005024 GO:0005114 GO:0005534 GO:0005539 GO:0005615 GO:0005886 GO:0005925 GO:0006355 GO:0007155 GO:0007179 GO:0009410 GO:0009897 GO:0009986 GO:0010628 GO:0010629 GO:0015026 GO:0016477 GO:0016604 GO:0017015 GO:0022009 GO:0022617 GO:0030155 GO:0030336 GO:0030509 GO:0030512 GO:0030513 GO:0030546 GO:0032967 GO:0034713 GO:0035912 GO:0042060 GO:0042127 GO:0042325 GO:0042802 GO:0042803 GO:0043235 GO:0045766 GO:0045944 GO:0048185 GO:0048745 GO:0048844 GO:0048845 GO:0048870 GO:0050431 GO:0051001 GO:0051897 GO:0055009 GO:0060326 GO:0060348 GO:0060391 GO:0070278 GO:0070483 GO:0071260 GO:0072563 GO:0097084 GO:1905007 GO:1905065 GO:1905222
GL_000272	Calreticulin	P27797	2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY 7QPD 8TZO 8TZR	Homo sapiens (human)	9606	DNA binding ERAD pathway MHC class I peptide loading complex RNA binding acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endocytic vesicle lumen endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum external side of plasma membrane extracellular exosome extracellular region extracellular space focal adhesion glucocorticoid receptor signaling pathway hormone binding integrin binding intracellular calcium ion homeostasis iron ion binding lumenal side of endoplasmic reticulum membrane mRNA binding membrane molecular sequestering activity negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm phagocytic vesicle membrane positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding chaperone protein folding in endoplasmic reticulum protein folding protein localization to nucleus protein maturation by protein folding protein stabilization protein-folding chaperone binding regulation of DNA-templated transcription regulation of apoptotic process regulation of meiotic nuclear division response to estradiol response to glycoside response to testosterone response to xenobiotic stimulus ribosome sarcoplasmic reticulum lumen sequestering of calcium ion smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding unfolded protein binding zinc ion binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003677 GO:0003723 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005840 GO:0005925 GO:0006355 GO:0006457 GO:0006611 GO:0006874 GO:0007283 GO:0008270 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010595 GO:0010628 GO:0016020 GO:0017148 GO:0022417 GO:0030246 GO:0030670 GO:0030866 GO:0031625 GO:0032355 GO:0033018 GO:0033116 GO:0033144 GO:0033574 GO:0034504 GO:0034975 GO:0036503 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0042921 GO:0042981 GO:0044183 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0051087 GO:0051208 GO:0055007 GO:0060473 GO:0062023 GO:0070062 GO:0071257 GO:0071285 GO:0071682 GO:0090398 GO:0098553 GO:0098586 GO:0140313 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_003393	Fructose-1,6-bisphosphatase 1	P09467	1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 6LS5 6LW2 7C9Q 7CVH 7CVN 7CWE 7EZF 7EZP 7EZR 7WJV 7WVB	Homo sapiens (human)	9606	AMP binding RNA polymerase II-specific DNA-binding transcription factor binding cellular hyperosmotic salinity response cellular hypotonic salinity response cellular response to cAMP cellular response to insulin stimulus cellular response to magnesium ion cellular response to phorbol 13-acetate 12-myristate cellular response to raffinose cellular response to xenobiotic stimulus cytoplasm cytosol dephosphorylation extracellular exosome fructose 1,6-bisphosphate 1-phosphatase activity fructose 1,6-bisphosphate metabolic process fructose 6-phosphate metabolic process fructose metabolic process gluconeogenesis identical protein binding metal ion binding monosaccharide binding negative regulation of Ras protein signal transduction negative regulation of cell growth negative regulation of glycolytic process negative regulation of transcription by RNA polymerase II nucleus regulation of gluconeogenesis response to nutrient levels sucrose biosynthetic process	GO:0000122 GO:0005634 GO:0005737 GO:0005829 GO:0005986 GO:0006000 GO:0006002 GO:0006094 GO:0006111 GO:0016208 GO:0016311 GO:0030308 GO:0030388 GO:0031667 GO:0032869 GO:0042132 GO:0042802 GO:0045820 GO:0046580 GO:0046872 GO:0048029 GO:0061629 GO:0070062 GO:0071286 GO:0071320 GO:0071466 GO:0071475 GO:0071477 GO:0097403 GO:1904628
GL_000876	Polycystin-1	P98161	1B4R 6A70	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane Golgi-associated vesicle membrane Wnt receptor activity anatomical structure morphogenesis basolateral plasma membrane branching morphogenesis of an epithelial tube calcium channel activity calcium channel complex calcium ion transmembrane transport calcium ion transport calcium-independent cell-matrix adhesion carbohydrate binding cartilage condensation cartilage development cation channel complex cell surface cell-cell signaling by wnt cell-matrix adhesion ciliary membrane cilium cytoplasm detection of mechanical stimulus digestive tract development embryonic placenta development endoplasmic reticulum establishment of epithelial cell polarity extracellular exosome genitalia development heart development homophilic cell adhesion via plasma membrane adhesion molecules in utero embryonic development kidney development lateral plasma membrane liver development lung epithelium development lymph vessel morphogenesis membrane mesonephric duct development mesonephric tubule development metanephric ascending thin limb development metanephric collecting duct development metanephric distal tubule morphogenesis metanephric proximal tubule development migrasome mitocytosis motile cilium neural tube development nucleus peptidyl-serine phosphorylation placenta blood vessel development plasma membrane polycystin complex positive regulation of cytosolic calcium ion concentration positive regulation of transcription by RNA polymerase II protein domain specific binding protein export from nucleus protein heterotetramerization protein kinase binding receptor signaling pathway via JAK-STAT regulation of G1/S transition of mitotic cell cycle regulation of cell adhesion regulation of cell cycle regulation of mitotic spindle organization regulation of proteasomal protein catabolic process response to fluid shear stress skin development spinal cord development transcription regulator inhibitor activity transmembrane transporter binding	GO:0000139 GO:0001502 GO:0001701 GO:0001822 GO:0001889 GO:0001892 GO:0002133 GO:0005262 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005886 GO:0005929 GO:0006611 GO:0006816 GO:0007156 GO:0007160 GO:0007161 GO:0007204 GO:0007259 GO:0007507 GO:0009653 GO:0009986 GO:0016020 GO:0016323 GO:0016328 GO:0018105 GO:0019901 GO:0019904 GO:0021510 GO:0021915 GO:0030155 GO:0030246 GO:0030660 GO:0031514 GO:0034405 GO:0034703 GO:0034704 GO:0036303 GO:0042813 GO:0043588 GO:0044325 GO:0045944 GO:0048565 GO:0048754 GO:0048806 GO:0050982 GO:0051216 GO:0051290 GO:0051726 GO:0060170 GO:0060236 GO:0060428 GO:0060674 GO:0061136 GO:0070062 GO:0070588 GO:0072164 GO:0072177 GO:0072205 GO:0072218 GO:0072237 GO:0072287 GO:0090162 GO:0140416 GO:0140494 GO:0160040 GO:0198738 GO:2000045
GL_004606	Basigin	P35613	3B5H 3I84 3I85 3QQN 3QR2 4U0Q 5X0T 5XF0 6LYY 6LZ0 7CKO 7CKR 7DA5 7DAA 7DCE 7XY8	Homo sapiens (human)	9606	Golgi membrane acrosomal membrane angiogenesis axon guidance axon basolateral plasma membrane cadherin binding cell surface receptor signaling pathway cell-cell adhesion mediator activity decidualization dendrite self-avoidance embryo implantation endoplasmic reticulum membrane endosome endothelial tube morphogenesis extracellular exosome focal adhesion homophilic cell adhesion via plasma membrane adhesion molecules intracellular membrane-bounded organelle mannose binding melanosome membrane mitochondrion neural retina development neutrophil chemotaxis odontogenesis of dentin-containing tooth photoreceptor cell maintenance photoreceptor inner segment photoreceptor outer segment plasma membrane positive regulation of endothelial cell migration positive regulation of interleukin-6 production positive regulation of matrix metallopeptidase secretion positive regulation of vascular endothelial growth factor production positive regulation of viral entry into host cell protein localization to plasma membrane response to cAMP response to mercury ion response to peptide hormone sarcolemma signaling receptor activity virus receptor activity	GO:0000139 GO:0001525 GO:0001618 GO:0001750 GO:0001917 GO:0002080 GO:0003407 GO:0005537 GO:0005739 GO:0005768 GO:0005789 GO:0005886 GO:0005925 GO:0007156 GO:0007166 GO:0007411 GO:0007566 GO:0010575 GO:0010595 GO:0016020 GO:0016323 GO:0030424 GO:0030593 GO:0032755 GO:0038023 GO:0042383 GO:0042470 GO:0042475 GO:0043231 GO:0043434 GO:0045296 GO:0045494 GO:0046598 GO:0046689 GO:0046697 GO:0051591 GO:0061154 GO:0070062 GO:0070593 GO:0072659 GO:0098632 GO:1904466
GL_002347	Neural cell adhesion molecule 1	P13591	2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	Homo sapiens (human)	9606	Golgi membrane cell adhesion cell surface collagen-containing extracellular matrix commissural neuron axon guidance cytosol epithelial to mesenchymal transition external side of plasma membrane extracellular region membrane plasma membrane regulation of semaphorin-plexin signaling pathway virus receptor activity	GO:0000139 GO:0001618 GO:0001837 GO:0005576 GO:0005829 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0062023 GO:0071679 GO:2001260
GL_001231	Alpha-mannosidase 2	Q16706		Homo sapiens (human)	9606	Golgi medial cisterna Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding cis-Golgi network extracellular exosome hydrolase activity, hydrolyzing N-glycosyl compounds in utero embryonic development liver development lung alveolus development mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity membrane metal ion binding mitochondrion organization positive regulation of neurogenesis protein glycosylation protein homodimerization activity respiratory gaseous exchange by respiratory system retina morphogenesis in camera-type eye vacuole organization viral protein processing	GO:0000139 GO:0001701 GO:0001889 GO:0004559 GO:0004572 GO:0005797 GO:0005801 GO:0006013 GO:0006486 GO:0006491 GO:0007005 GO:0007033 GO:0007585 GO:0016020 GO:0016799 GO:0019082 GO:0030246 GO:0042803 GO:0046872 GO:0048286 GO:0050769 GO:0060042 GO:0070062
GL_002758	HLA class II histocompatibility antigen, DRB1 beta chain	P01911	1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FYT 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2SEB 2WBJ 2XN9 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6HBY 6NIX 6QZA 6QZC 6QZD 6R0E 6V0Y 6V13 6V15 6V18 6V19 6V1A 8TBP	Homo sapiens (human)	9606	CD4 receptor binding ER to Golgi transport vesicle membrane Golgi membrane MHC class II protein complex binding MHC class II protein complex MHC class II receptor activity T cell receptor binding T cell receptor signaling pathway T-helper 1 type immune response antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II autolysosome membrane cell surface clathrin-coated endocytic vesicle membrane detection of bacterium endocytic vesicle membrane epidermis development external side of plasma membrane extracellular exosome extracellular space humoral immune response immune response immunological synapse inflammatory response to antigenic stimulus intermediate filament late endosome membrane lumenal side of endoplasmic reticulum membrane lysosomal membrane macrophage differentiation membrane myeloid dendritic cell antigen processing and presentation negative regulation of T cell proliferation negative regulation of inflammatory response to antigenic stimulus negative regulation of type II interferon production peptide antigen assembly with MHC class II protein complex peptide antigen binding plasma membrane polysaccharide binding positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade positive regulation of T cell activation positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immune response to tumor cell positive regulation of canonical NF-kappaB signal transduction positive regulation of immune response positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of kinase activity positive regulation of memory T cell differentiation positive regulation of monocyte differentiation positive regulation of protein phosphorylation positive regulation of viral entry into host cell protein tetramerization regulation of T-helper cell differentiation regulation of interleukin-10 production regulation of interleukin-4 production signal transduction structural constituent of cytoskeleton trans-Golgi network membrane transport vesicle membrane	GO:0000139 GO:0001772 GO:0001916 GO:0001934 GO:0002437 GO:0002469 GO:0002491 GO:0002503 GO:0002842 GO:0002862 GO:0005200 GO:0005615 GO:0005765 GO:0005882 GO:0005886 GO:0006955 GO:0006959 GO:0007165 GO:0008544 GO:0009897 GO:0009986 GO:0012507 GO:0016020 GO:0016045 GO:0019886 GO:0023026 GO:0030225 GO:0030247 GO:0030658 GO:0030666 GO:0030669 GO:0031902 GO:0032395 GO:0032588 GO:0032653 GO:0032673 GO:0032689 GO:0032831 GO:0033674 GO:0035774 GO:0042088 GO:0042130 GO:0042605 GO:0042608 GO:0042609 GO:0042613 GO:0043123 GO:0043382 GO:0043410 GO:0045622 GO:0045657 GO:0045893 GO:0046598 GO:0050778 GO:0050852 GO:0050870 GO:0051262 GO:0070062 GO:0070374 GO:0098553 GO:0120281 GO:2000516
GL_002832	HLA class II histocompatibility antigen, DR alpha chain	P01903	1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4H1L 4H25 4H26 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 5V4M 5V4N 6ATF 6ATI 6ATZ 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6NIX 6QZA 6QZC 6QZD 6R0E 6V0Y 6V13 6V15 6V18 6V19 6V1A 7N19 7NZE 7O00 7YX9 7YXB 7Z0Q 8CMB 8CMC 8CMD 8CME 8CMF 8CMG 8CMH 8CMI 8EUQ 8TBP	Homo sapiens (human)	9606	ER to Golgi transport vesicle membrane Golgi membrane MHC class II protein complex binding MHC class II protein complex MHC class II receptor activity T cell receptor binding adaptive immune response antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II autolysosome membrane cell surface clathrin-coated endocytic vesicle membrane cognition early endosome membrane endocytic vesicle membrane extracellular exosome immune response immunological synapse late endosome membrane lumenal side of endoplasmic reticulum membrane lysosomal membrane lysosome myeloid dendritic cell antigen processing and presentation peptide antigen assembly with MHC class II protein complex peptide antigen binding plasma membrane polysaccharide binding positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of T cell activation positive regulation of T cell mediated cytotoxicity positive regulation of immune response positive regulation of memory T cell differentiation regulation of T-helper cell differentiation trans-Golgi network membrane transport vesicle membrane	GO:0000139 GO:0001772 GO:0001916 GO:0002250 GO:0002469 GO:0002491 GO:0002503 GO:0002504 GO:0005764 GO:0005765 GO:0005886 GO:0006955 GO:0009986 GO:0012507 GO:0019886 GO:0023026 GO:0030247 GO:0030658 GO:0030666 GO:0030669 GO:0031901 GO:0031902 GO:0032395 GO:0032588 GO:0032831 GO:0042605 GO:0042608 GO:0042613 GO:0043382 GO:0045622 GO:0050778 GO:0050870 GO:0050890 GO:0070062 GO:0098553 GO:0120281 GO:2000516
GL_002343	Cation-independent mannose-6-phosphate receptor	P11717	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32 8AFZ	Homo sapiens (human)	9606	G protein-coupled receptor signaling pathway G-protein alpha-subunit binding Golgi apparatus Golgi membrane animal organ regeneration cell surface clathrin coat clathrin-coated endocytic vesicle membrane early endosome endocytic vesicle endosome membrane endosome enzyme binding extracellular exosome focal adhesion identical protein binding insulin-like growth factor II binding insulin-like growth factor binding insulin-like growth factor receptor activity late endosome liver development lysosomal transport mannose binding membrane nuclear envelope lumen perinuclear region of cytoplasm phosphoprotein binding plasma membrane positive regulation by host of viral process positive regulation of apoptotic process post-embryonic development receptor-mediated endocytosis response to retinoic acid response to tetrachloromethane retinoic acid binding retromer complex binding secretory granule membrane signal transduction signaling receptor activity spermatogenesis trans-Golgi network membrane trans-Golgi network transport vesicle trans-Golgi network transport vesicle	GO:0000139 GO:0001889 GO:0001965 GO:0001972 GO:0005010 GO:0005520 GO:0005537 GO:0005641 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0005925 GO:0006898 GO:0007041 GO:0007165 GO:0007186 GO:0007283 GO:0009791 GO:0009986 GO:0010008 GO:0016020 GO:0019899 GO:0030118 GO:0030133 GO:0030139 GO:0030140 GO:0030667 GO:0030669 GO:0031100 GO:0031995 GO:0032526 GO:0032588 GO:0038023 GO:0042802 GO:0043065 GO:0044794 GO:0048471 GO:0051219 GO:0070062 GO:1904772 GO:1905394
GL_004115	Glucosamine 6-phosphate N-acetyltransferase	Q96EK6	2HUZ 2O28 3CXP 3CXQ 3CXS	Homo sapiens (human)	9606	Golgi membrane UDP-N-acetylglucosamine biosynthetic process cytosol endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum endosome membrane glucosamine 6-phosphate N-acetyltransferase activity identical protein binding monosaccharide binding	GO:0000139 GO:0004343 GO:0005783 GO:0005793 GO:0005829 GO:0006048 GO:0010008 GO:0042802 GO:0048029
GL_001238	Alpha-mannosidase 2x	P49641		Homo sapiens (human)	9606	Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding hydrolase activity, hydrolyzing N-glycosyl compounds mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein glycosylation	GO:0000139 GO:0004559 GO:0004572 GO:0006013 GO:0006486 GO:0006491 GO:0016799 GO:0030246 GO:0046872
GL_001699	Lysosomal alpha-mannosidase	O00754		Homo sapiens (human)	9606	Golgi membrane N-glycan processing alpha-mannosidase activity azurophil granule lumen carbohydrate binding extracellular exosome extracellular region extracellular space intracellular membrane-bounded organelle learning or memory lysosomal lumen lysosome mannose metabolic process metal ion binding nucleoplasm oligosaccharide catabolic process protein deglycosylation protein modification process	GO:0000139 GO:0004559 GO:0005576 GO:0005615 GO:0005654 GO:0005764 GO:0006013 GO:0006491 GO:0006517 GO:0007611 GO:0009313 GO:0030246 GO:0035578 GO:0036211 GO:0043202 GO:0043231 GO:0046872 GO:0070062
GL_000891	Polypeptide N-acetylgalactosaminyltransferase 11	Q8NCW6		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane Notch binding Notch receptor processing Notch signaling involved in heart development O-glycan processing carbohydrate binding cilium assembly determination of left/right symmetry metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via threonine protein O-linked glycosylation regulation of Notch signaling pathway	GO:0000139 GO:0004653 GO:0005112 GO:0005794 GO:0006493 GO:0007220 GO:0007368 GO:0008593 GO:0016266 GO:0018243 GO:0030246 GO:0046872 GO:0060271 GO:0061314
GL_000914	Polypeptide N-acetylgalactosaminyltransferase 3	Q14435		Homo sapiens (human)	9606	Golgi apparatus Golgi cisterna membrane Golgi membrane O-glycan processing calcium ion binding carbohydrate binding carbohydrate metabolic process extracellular exosome fibroblast growth factor receptor signaling pathway manganese ion binding membrane perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via serine protein O-linked glycosylation via threonine protein O-linked glycosylation spermatogenesis	GO:0000139 GO:0004653 GO:0005509 GO:0005794 GO:0005975 GO:0006493 GO:0007283 GO:0008543 GO:0016020 GO:0016266 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0048471 GO:0070062
GL_000912	Polypeptide N-acetylgalactosaminyltransferase 2	Q10471	2FFU 2FFV 4D0T 4D0Z 4D11 5AJN 5AJO 5AJP 5FV9 5NDF 6E7I 6EGS 6NQT	Homo sapiens (human)	9606	Golgi apparatus Golgi cisterna membrane Golgi membrane Golgi stack O-glycan processing carbohydrate binding endoplasmic reticulum membrane extracellular region manganese ion binding membrane perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via serine protein O-linked glycosylation via threonine protein O-linked glycosylation protein maturation	GO:0000139 GO:0004653 GO:0005576 GO:0005789 GO:0005794 GO:0005795 GO:0006493 GO:0016020 GO:0016266 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0048471 GO:0051604
GL_000883	Polypeptide N-acetylgalactosaminyltransferase 1	Q10472		Homo sapiens (human)	9606	Golgi cisterna membrane Golgi membrane O-glycan processing carbohydrate binding endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane extracellular region manganese ion binding membrane perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via serine protein O-linked glycosylation via threonine protein O-linked glycosylation viral protein processing	GO:0000139 GO:0004653 GO:0005576 GO:0005789 GO:0006493 GO:0016020 GO:0016266 GO:0018242 GO:0018243 GO:0019082 GO:0030145 GO:0030246 GO:0032580 GO:0033116 GO:0048471
GL_000794	N-acetylgalactosaminyltransferase 7	Q86SF2	6IWQ 6IWR	Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding carbohydrate metabolic process extracellular exosome membrane metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0005975 GO:0006493 GO:0016020 GO:0016266 GO:0030246 GO:0046872 GO:0070062
GL_000925	Polypeptide N-acetylgalactosaminyltransferase 5	Q7Z7M9		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding glycosaminoglycan biosynthetic process metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006024 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_000897	Polypeptide N-acetylgalactosaminyltransferase 13	Q8IUC8		Homo sapiens (human)	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation via serine protein O-linked glycosylation via threonine protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0018242 GO:0018243 GO:0030246 GO:0046872

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