GlyCosmos Portal

Danio rerio (zebrafish)

Summary

Taxonomy ID: 7955
PubChem Taxonomy: 7955

Genes (748) Glycans (175) Glycoproteins (596) Lectins (18) Pathways (261)

Displaying entries **151 - 175** of **261** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol	GlyTouCan ID
RHO GTPases regulate CFTR trafficking	Cystic fibrosis transmembrane conductance regulator Golgi-associated PDZ and coiled-coil motif-containing Ras homolog family member Q	Q1LX78 Q6PHG0 Q7ZVI3	cftr fe38f01 gopc rhoq wu:fe38f01 wu:fi15a09 zgc:55997 zgc:56254 zgc:65853
Miscellaneous transport and binding events	Cystinosin precursor Leucine rich repeat containing 8 family, member A Leucine rich repeat containing 8 family, member D Leucine-rich repeat-containing 8 VRAC subunit Ab Magnesium transporter NIPA1 Magnesium transporter protein 1 NIPA-like domain containing 3 Progressive ankylosis protein homolog B Si	A2BF98 E7FB32 P58368 Q08BM6 Q4V8W3 Q503T0 Q5XJN7 Q6DHM4 Q7ZV50	ankh ankhb ctns lrrc8a lrrc8aa lrrc8ab lrrc8d lrrc8db magt1 nipa1 nipal3 npal3 si:zfos-323e3.4 wu:fb18g12 wu:fc12a05 wu:fi21b10 zgc:101743 zgc:110194 zgc:153223 zgc:92224
Glycosphingolipid catabolism	Cytosolic beta-glucosidase Neutral ceramidase Non-lysosomal glucosylceramidase Sphingomyelin phosphodiesterase 4 exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase sphingomyelin phosphodiesterase sphingomyelin phosphodiesterase	A0JMM3 A7TUD6 B1B5D9 E7F5W0 F1QUD7 Q4V9A4 Q502A1 Q503Z4 Q5W7F1 Q6PFJ7	NSMase asah2 gba2 gba3 im:6912336 im:6912508 nSMase2 neu3.2 neu3.3 neu3.5 neu4 neuc.1 sb:eu489 si:ch73-316n6.2 si:dkey-11j5.6 smpd2 smpd2a smpd3 smpd4 zgc:100806 zgc:109998 zgc:153998	G58161NS
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Cytosolic endo-beta-N-acetylglucosaminidase E3 ubiquitin-protein ligase AMFR Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Proteasome (Prosome, macropain) 26S subunit, ATPase, 1a Proteasome (Prosome, macropain) 26S subunit, ATPase, 1b Transitional endoplasmic reticulum ATPase UBX domain-containing protein 1 UV excision repair protein RAD23 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A1L251 F1QB30 Q32PS7 Q3B7P7 Q503I8 Q6IQ72 Q6NXA9 Q7SXA3 Q7ZU99 Q7ZWD1	amfra cdc48 engase hm:zeh0386 ik:tdsubc_1f2 ngly1 psmc1 psmc1a psmc1b rad23ab rps27a saks1 tdsubc_1f2 uba52 ubxn1 vcp wu:fa91f08 wu:fb05d04 wu:fj14c10 xx:tdsubc_1f2 zgc:123344 zgc:56516 zgc:66168 zgc:86923	G03934XO G25577BM G28233ME G51034LA G86419OL
Acyl chain remodelling of PC	Cytosolic phospholipase A2 gamma-like Cytosolic phospholipase A2 Group XIIA secretory phospholipase A2 precursor Lysophosphatidylcholine acyltransferase 1 Lysophosphatidylcholine acyltransferase 2 Phospholipase A2 Phospholipase B-like Retinoic acid receptor responder 3-like lysoplasmalogenase lysoplasmalogenase phospholipase A2	A3KNJ5 B3DJ80 P50392 Q0P4C9 Q1LWG4 Q32PR6 Q502J0 Q5BLD1 Q5U3S0 Q6DHK9 Q6DHQ7	aytl1 aytl2 cpla2 im:7137034 im:7138859 lpcat1 lpcat2 pla2g10 pla2g12a pla2g3 pla2g4 pla2g4a plbd1 plbd1a rarres3l tmem86a tmem86b zgc:101699 zgc:113571 zgc:153124 zgc:162119
Acyl chain remodelling of PI	Cytosolic phospholipase A2 gamma-like Cytosolic phospholipase A2 Group XIIA secretory phospholipase A2 precursor Lysophospholipid acyltransferase 7 Phospholipase A2 Phospholipase B-like Retinoic acid receptor responder 3-like	A3KNJ5 B3DJ80 P50392 Q5U3S0 Q6DHK9 Q6DHQ7 Q7SZQ0	cpla2 im:7138859 leng4 mboat7 oact7 pla2g10 pla2g12a pla2g4 pla2g4a plbd1 plbd1a rarres3l zgc:101699 zgc:162119
Arachidonate metabolism	Cytosolic phospholipase A2 Diacylglycerol O-acyltransferase 2 Fatty-acid amide hydrolase 2-A	P50392 Q4V9F0 Q6DH69	cpla2 dgat2 faah2a pla2g4 pla2g4a
Acyl chain remodelling of PS	Cytosolic phospholipase A2 Group XIIA secretory phospholipase A2 precursor Phospholipase A1 member A Phospholipase A2 Retinoic acid receptor responder 3-like	A3KNJ5 P50392 Q6DHK9 Q6DHQ7 Q6NYZ4	cpla2 pla1a pla2g10 pla2g12a pla2g4 pla2g4a rarres3l zgc:162119
PRC2 methylates histones and DNA	DNA (cytosine-5-)-methyltransferase Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2 Histone H2B 3 Histone H2B Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Metal-response element-binding transcription factor 2 Polycomb protein eed Polycomb protein suz12-B Protein Jumonji Uncharacterized protein LOC100126107 Zinc finger protein AEBP2	A3KPR4 A7E2M8 A7MCA8 B0R1D5 B3DJF8 Q08BS4 Q0Z946 Q1JQ07 Q1LVC2 Q4QRF4 Q566T0 Q588C6 Q5BJA5 Q5XJK2 Q6P3H7 Q6PC60 Q6PI20 Q71PD7 Q7SXV2 Q7ZTT0 Q7ZTY4 R4GE15	LOC100150038 LOC100329358 LOC100331412 LOC100332229 LOC103908680 LOC108181627 LOC562770 LOC570661 LOC794549 aebp2 cb633 dnmt3b dnmt3bb.1 dnmt4 eed ezh2 h2af1al h2afvb h2afvl h2afx1 h2afza h2av h2ax1 h2az2a h2az2b h3-5 h3f3a h3f3b.1 h3f3c h3f3d hist1h4l hist2h2l im:6896397 jarid2b jmj mtf2 rbb4 rbb4l rbbp4 rbbp7 si:ch211-113a14.17 si:ch211-113a14.22 si:ch211-113a14.29 si:ch211-113a14.6 si:ch73-36p18.4 si:dkey-108k21.12 si:dkey-108k21.18 si:dkey-108k21.28 si:dkey-23a13.7 suz12 suz12b wu:cegs2813 zgc:112234 zgc:113984 zgc:136399 zgc:152758 zgc:165555 zgc:173585 zgc:173587 zgc:194998 zgc:56685
Keratinization	Desmocollin 2-like protein Desmoglein-2.1 Desmoplakin-A Junction plakoglobin a Keratin 18b Keratin 5 Keratin 93 Keratin 95 Keratin 97 Keratin, type II cytoskeletal 8 Plakophilin 3a Plakophilin-2 Uncharacterized protein LOC100009654 Uncharacterized protein LOC768289	A0A8M2BID5 A2RV44 B0BF33 F1Q8J9 F1QSQ0 F1QV31 H2EQR6 Q05AL9 Q1RLR3 Q6DG66 Q6DHU3 Q6NWF6 Q6PHE4 Q9PVF7	cb112 cb80 ckii dsc dsc2 dsc2l dsg2 dsg2.1 dsga dspa jup jupa krt18b krt2-8 krt5 krt8 krt93 krt94 krt95 krt97 krtt1c6 pkp2 pkp3 pkp3a sb:cb112 sb:cb481 wu:fa91c11 wu:fa91g11 wu:fa96h10 wu:fa97f09 wu:fb02h09 wu:fb58f07 wu:fj02d02 wu:fk69a12 wu:fk78b12 zfCKII zgc:136656 zgc:66015
Formation of the cornified envelope	Desmocollin 2-like protein Desmoglein-2.1 Desmoplakin-A Junction plakoglobin a Lipase Plakophilin 3a Plakophilin-2	A0A8M2BID5 B0BF33 F1Q8J9 F1QSQ0 H2EQR6 Q7ZTR9 Q9PVF7	cb80 dsc dsc2 dsc2l dsg2 dsg2.1 dsga dspa fb73g06 jup jupa lipf pkp2 pkp3 pkp3a wu:fa97f09 wu:fb73g06 wu:fk69a12 zgc:136656 zgc:56632
PCP/CE pathway	Disheveled-associated activator of morphogenesis 1 Dishevelled, dsh homolog 2 (Drosophila) Frizzled 7b Frizzled class receptor 3b Frizzled-1 Frizzled-6 Profilin Profilin Profilin Protein Wnt-1 Protein Wnt-4a Protein Wnt-5b Protein Wnt Rac family small GTPase 2 Rac family small GTPase 3a Rac family small GTPase 3b Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoA-C	A0JBX4 A1BPR0 A9JRY8 B3DJ49 E7F0A1 P24257 P47793 Q5RHJ3 Q6AZA1 Q6DGB7 Q6IQN5 Q6P0Y7 Q7T2E8 Q7ZSZ9 Q802D5 Q803Q5 Q90ZT3 Q92050	daam1b daam1l dvl2 fa91a03 fc83b10 frizzled3b fz10 fz3 fz7 fzd1 fzd3b fzd3l fzd6 fzd7a hm:zeh0341 id:ibd2735 int-1 pfn1 pfn2 pfn2a pfn2b pfn2l rac1 rac1a rac2 rac3 rac3a rac3b rhoac sb:cb813 sb:eu471 si:ch211-87i20.1 wnt-1 wnt-4 wnt-5 wnt1 wnt4 wnt4a wnt5 wnt5a wnt5b wu:fa91a03 wu:fb01g08 wu:fb02e10 wu:fb54f09 wu:fb95b01 wu:fc05d12 wu:fc17e10 wu:fc83b10 wu:fd16e02 wu:fd58f06 wu:fi35b08 wu:fo71e09 wu:fp54a02 zg03 zg07 zg10 zgc:100831 zgc:194774 zgc:55372 zgc:55823 zgc:55917 zgc:65879 zgc:77440 zgc:86686 zgc:86790 zgc:86934
Crosslinking of collagen fibrils	Dorsal-ventral patterning tolloid-like protein 1 Lysyl oxidase homolog 2B Lysyl oxidase homolog 3B Lysyl oxidase homolog Metalloendopeptidase protein-lysine 6-oxidase	A1L1V4 B8A4W9 O57460 Q2ABP1 Q2PS19 Q6NYT8	bmp1a lox loxa loxl1 loxl2b loxl3b mfn si:ch211-238c15.1 tld tll1 tolloid zgc:77447
MAP2K and MAPK activation	Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Interleukin-17 receptor D Mitogen-activated protein kinase Mitogen-activated protein kinase Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 WD repeat domain-containing protein 83 non-specific serine/threonine protein kinase	Q1LY62 Q4V947 Q503S6 Q5FBD1 Q6DEG4 Q6DH44 Q7ZVK8 Q7ZW72 Q8QHJ9	ARAF ERK1 araf cb208 fa56c06 fi06b09 il17rd lamtor2 lamtor3 map2k1 map2k2 map2k2a mapk1 mapk3 mapksp1 mek1 mek2 morg1 sb:eu994 sef si:ch211-242m18.2 wdr83 wu:fa56c06 wu:fi06b09 wu:fj56a12 wu:fj61b01 wu:fk45h07 zERK1 zERK2 zgc:123171 zgc:56557 zgc:92074
Regulation of KIT signaling	E3 ubiquitin-protein ligase CBL Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Kit ligand Mast/stem cell growth factor receptor kita Proto-oncogene tyrosine-protein kinase Src Son of sevenless homolog Tyrosine-protein kinase fynb Tyrosine-protein kinase yes Tyrosine-protein kinase	A1A5H8 A2RRV5 F1RDG9 Q1JPZ3 Q1RLY5 Q56JH6 Q5RKN6 Q5U376 Q6PC73 Q8JFR5	cbl fb18e12 fj59e07 fynb grb2 grb2a grb2b kit kita kitla kitlga lck sos1 sparse src wu:fb18e12 wu:fb34e06 wu:fd16a12 wu:fj59e07 yes yes1 zgc:103549 zgc:136695 zgc:158274 zgc:73077 zgc:92560
Regulation of FZD by ubiquitination	E3 ubiquitin-protein ligase znrf3 Frizzled 8a protein Frizzled 8b protein Frizzled-5 Frizzled-6 Low density lipoprotein receptor-related protein 5 Low-density lipoprotein receptor-related protein Protein Wnt R-spondin 2 R-spondin 4 R-spondin-1 R-spondin-3 Reticulon-4 receptor precursor Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5WWA0 B3DIG4 B5L5I6 F1Q5C9 F1QTJ4 M5AN99 Q3B7P7 Q5R328 Q6DHR0 Q6IYD9 Q6P0Y7 Q6X3Y5 Q7SXA3 Q9PWK6 Q9YI00	LRP6 NgR ZG06 Zfz8b Zwnt[a] fz5 fz6 fz8a fz8b fzA fzc fzd5 fzd6 fzd8a fzd8b hm:zeh0386 ik:tdsubc_1e1 ik:tdsubc_1f2 lrp5 lrp6 ngr rps27a rspo1 rspo2 rspo3 rspo4 rtn4r si:ch211-149p10.1 si:dkey-107i16.4 tdsubc_1f2 uba52 wnt3 wnt3 l wnt3a wnt3l wnt[a] wu:fa91f08 wu:fd02c05 xx:tdsubc_1e1 xx:tdsubc_1f2 zfzA zg05 zgc:123344 zgc:65879 zgc:66168 zgc:77440 znrf3
Vitamin B2 (riboflavin) metabolism	Ectonucleotide pyrophosphatase/phosphodiesterase 1 FAD synthase Solute carrier family 52, riboflavin transporter, member 3-A Tartrate-resistant acid phosphatase type 5	B0JZL7 B0S5Y3 Q68EH8 Q7SXT1	TRAP acp5 acp5a enpp1 flad1 rft2a sb:cb576 si:ch211-142e24.2 slc52a3a wu:fb19f01 wu:fb30b03 wu:fi14e01 wu:fj66f03 zgc:136238 zgc:63825
Heme signaling	Embryonic alpha globin e1 Embryonic globin beta e2 Hemoglobin beta embryonic-3 Hemoglobin subunit beta-1 Hemoglobin, beta adult 2 Membrane-associated progesterone receptor component 2 Proton-coupled folate transporter	Q5BLF6 Q6ZM12 Q7SZC7 Q7T1B0 Q7ZT21 Q7ZWG6 Q90486	HBA2r HBAA1 LOC100334599 OTTDARP00000001843 OTTDARP00000001846 OTTDARP00000002003 SI:dZ118J2.10 SI:dZ118J2.8 ba1 ba1l dZ118J2.6 hba2 hbae1 hbae1.1 hbae1.2 hbae1.3 hbba2 hbbe2 hbbe3 pcft pgrmc2 si:by119c3.1 si:by119c3.3 si:xx-119c3.3 slc46a1 wu:fa12a11 wu:fb25g12 wu:fb74f06 wu:fd12f11 zgc:110736 zgc:56692 zgc:86936
Opsins	Encephalopsin Melanopsin-A Opsin-1, short-wave-sensitive 1 Opsin-5 RPE-retinal G protein-coupled receptor Red-sensitive opsin-1 Red-sensitive opsin-2 Retinal pigment epithelium rhodopsin homolog/peropsin Rhodopsin	A9NJI7 E6P6L8 P35359 Q2KNE5 Q567Y2 Q66I55 Q8AYN0 Q9W6A7 Q9W6A9	Opn5m lws1 lws2 opn1lw1 opn1lw2 opn1sw1 opn1sw2 opn3 opn4 opn4a opn4d opn4m1 opn5 rdops rgr rgr1 rgra rho rrh si:ch211-105n9.2 sws1 uvops zfo2 zgc:103757 zgc:110660
EPH-Ephrin signaling	Ephrin B3 Ephrin type-A receptor 3 Ephrin type-A receptor 4a (Fragment) Ephrin type-B receptor 4a Ephrin-A1 Ephrin-A2 Ephrin-A3 Ephrin-A5b Ephrin-B1 Ephrin-B2b receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	O13146 O13148 O73875 O93431 P79727 P79728 Q5VSJ4 Q6NZS1 Q90YC5 Q90Z31 Q90Z32 Q90Z33 Q90ZN9	D160 EphA3 RTK2 al1 efna1 efna1b efna2 efna3 efna3b efna5 efna5b efnb1 efnb2b efnb3 efnb3b ek1 ek2 epha2 epha2a epha3 epha4 epha4a epha4b epha7 ephb4a ephrin-A3 eplg6 eplg7 fc10d03 fc51g03 hm:zeh0344 id:ibd2782 id:ibd5049 id:ibd5152 lerk6 lerk7 rtk2 rtk5 rtk6 si:dkey-23k6.1 wu:fc10d03 wu:fc51g03 zeh0344 zek1 zek2 zgc:100772 zgc:111938
ESR-mediated signaling	Esr2a protein Estrogen receptor Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Prostaglandin E synthase 3	O57521 P57717 Q5RG12 Q7SZQ8 Q7ZU32	ER[b]2 ER[b]a Tebp cPGES-1 cb820 erbeta2 esr esr1 esr2a hsp90a.2 hsp90a2 hsp90aa1.2 hsp90ab1 hsp90b hspc3 nr3a1 ptges3 ptges3a wu:fb98d06 zfER-beta2 zfER[b]2 zgc:65804 zgc:77131
FGFRL1 modulation of FGFR1 signaling	FGF receptor-like protein 1a FGF18a Fgf23 Fibroblast growth factor 17 Fibroblast growth factor 3 Fibroblast growth factor 8 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Sprouty-related, EVH1 domain containing 1 Sprouty-related, EVH1 domain-containing protein 2	B3DGE3 O57341 P48802 Q1XG76 Q5MK87 Q5TKR8 Q5TLE2 Q6NV01 Q6NYK3 Q6SJP8 Q7SX76 Q8AY90 Q9DFC9	fb14c08 fc89b01 fgf-10 fgf-3 fgf-8 fgf10 fgf10a fgf17 fgf17b fgf18 fgf18a fgf2 fgf22 fgf23 fgf3 fgf4 fgf5 fgf8 fgf8a fgfrl1 fgfrl1a fj51c03 id:ibd5158 si:dkey-21e2.2 si:dkeyp-74c5.3 spred1 spred2 wu:fb14c08 wu:fc89b01 wu:fd11d03 wu:fj51c03 zgc:109774 zgc:64084 zgc:85707
FRS-mediated FGFR2 signaling	FGF18a Fgf23 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 3 Fibroblast growth factor 8 Fibroblast growth factor receptor 2 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Putative fibroblast growth factor 1 Son of sevenless homolog	A2RRV5 B3DGE3 B3DHR9 E7F020 O57341 P48802 P79737 Q1XG76 Q2HXK8 Q38PL0 Q503B6 Q5MK87 Q5RKN6 Q5TKR8 Q5TLE1 Q5TLE2 Q6PBT8 Q6PC73 Q6SJP8 Q8AY90 Q8JG38 Q9DFC9	dob fb18e12 fc89b01 fgf-1 fgf-10 fgf-3 fgf-8 fgf1 fgf10 fgf10a fgf16 fgf17 fgf17b fgf18 fgf18a fgf2 fgf20a fgf22 fgf23 fgf3 fgf4 fgf5 fgf6b fgf7 fgf8 fgf8a fgfr2 fj59e07 frs3 grb2 grb2a grb2b hrasb hrasl id:ibd5158 nras si:dkey-21e2.2 si:dkeyp-74c5.3 sos1 wu:fb05c08 wu:fb18e12 wu:fb34e06 wu:fc89b01 wu:fd11d03 wu:fj59e07 zgc:103549 zgc:109774 zgc:110734 zgc:158274 zgc:194535 zgc:73077
SHC-mediated cascade:FGFR2	FGF18a Fgf23 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 3 Fibroblast growth factor 8 Fibroblast growth factor receptor 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Putative fibroblast growth factor 1 Son of sevenless homolog	A2RRV5 B3DGE3 B3DHR9 O57341 P48802 P79737 Q1XG76 Q2HXK8 Q38PL0 Q503B6 Q5MK87 Q5RKN6 Q5TKR8 Q5TLE1 Q5TLE2 Q6PBT8 Q6PC73 Q6SJP8 Q8AY90 Q8JG38 Q9DFC9	dob fb18e12 fc89b01 fgf-1 fgf-10 fgf-3 fgf-8 fgf1 fgf10 fgf10a fgf16 fgf17 fgf17b fgf18 fgf18a fgf2 fgf20a fgf22 fgf23 fgf3 fgf4 fgf5 fgf6b fgf7 fgf8 fgf8a fgfr2 fj59e07 grb2 grb2a grb2b hrasb hrasl id:ibd5158 nras si:dkey-21e2.2 si:dkeyp-74c5.3 sos1 wu:fb05c08 wu:fb18e12 wu:fb34e06 wu:fc89b01 wu:fd11d03 wu:fj59e07 zgc:103549 zgc:109774 zgc:110734 zgc:158274 zgc:194535 zgc:73077
FGFR2c ligand binding and activation	FGF18a Fgf23 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 8 Fibroblast growth factor receptor 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Putative fibroblast growth factor 1	B3DGE3 O57341 Q2HXK8 Q38PL0 Q5MK87 Q5TKR8 Q5TLE1 Q5TLE2 Q6PBT8 Q6SJP8 Q8JG38 Q9DFC9	dob fc89b01 fgf-1 fgf-8 fgf1 fgf16 fgf17 fgf17b fgf18 fgf18a fgf2 fgf20a fgf23 fgf4 fgf5 fgf6b fgf8 fgf8a fgfr2 id:ibd5158 wu:fb05c08 wu:fc89b01 zgc:194535

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