GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Neisseria gonorrhoeae	36-kDa proteins	Asialo-GM2 (Gangliotriosylceramide; GgO3)	Oligoglycosylceramides	Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva	GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	2115881
Bordetella pertussis	FHA (442-863)	Heparin	Glycosaminoglycans	WiDr cells, HeLa cells, Vero cells, Extracellular matrix (ECM)		Binding	11348687
Helicobacter pylori	Unknown	Fucose	Monosaccharides		Fuc	Binding	8574698
Escherichia coli	Unknown	unnamed ligand	Oligoglycosylceramides		GalNAc(b1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	2435422
Shigella dysenteriae	B subunit	Gb5 (Forssman glycolipid)	Oligoglycosylceramides	Dog small intestine	GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Not Binding	3543013
Cytomegalovirus	Unknown	Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH)	Oligoglycosylceramides		Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Not Binding	9780061
Fusobacterium nucleatum	Lectin-like proteins (adhesin)	Mr 36,900 PRG (Proline-Rich Glycoprotein)	Glycoproteins			Binding	1894623
Herpes simplex virus	Unknown	NAC-heparin (non-anticoagulant heparin)	Glycosaminoglycans	Human cervical cells		Binding	9420059
Helicobacter pylori	35S-labeled or 125I-labeled proteins	GM3(NeuGc)	Monosialoglycosphingolipids	Piglet intestine	NeuGc(a2-3)Gal(b1-4)Glc(b1-1)Cer	Not Binding	9499377
Norovirus	Unknown	Blood group A antigen	Oligosaccharides		GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-3)GlcNAc	Binding	18599458