GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Escherichia coli	Heat-labile enterotoxin (type II(LT-Iia))	GT1b	Trisialoglycosphingolipids		NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	3290106
Legionella pneumophila	Adhesins	GM2(NeuAc)	Monosialoglycosphingolipids	Human epithelial cells (respiratory tract)	GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Not Binding	14687561
Neisseria meningitidis	Type 4-pili	Thyroglobulin containing N-linked complex and hybrid (oligomannosidic) glycans	Glycoproteins	Bovine		Binding	16177210
Vibrio harveyi	CBP (chitin-binding proteins) 53-kDa	N-Acetylglucosamine	Monosaccharides		GlcNAc	Binding	10049907
Escherichia coli	Unknown	GM2(NeuAc)	Monosialoglycosphingolipids		GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	8574698
Actinomyces naeslundii	Unknown	Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside)	Monosialoglycosphingolipids	Human erythrocytes	NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Not Binding	2358461
Helicobacter pylori	Unknown	Heparan sulfate	Glycosaminoglycans			Binding	16088272
Escherichia coli	K99	Sialylparagloboside(NeuGc)	Monosialoglycosphingolipids		NeuGc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer	Binding	7849044
Neisseria gonorrhoeae	Unknown	NAC-heparin (non-anticoagulant heparin)	Glycosaminoglycans	Human epithelial cells		Binding	9420059
Influenza virus	Hemagglutinin H1(1934)	Human and avian receptors containing sialylated glycoconjugates	Glycoconjugates	Airways		Binding	18809496