GlyCosmos Portal

Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database	Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB)	June 1, 2016

Species	Pathogen Adherence Molecule	Ligand Name	Ligand Feature	Target Source	Glycan Sequence	Binding	PubMed ID
Escherichia coli	A and B polypeptide subunits	GD1b	Disialoglycosphingolipids		Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer	Binding	3290106
Clostridium botulinum	Botulinum neurotoxin	GT1b (complex with synaptotagmin II)	Trisialoglycosphingolipids	Presynaptic membrane of neuromuscular junction		Binding	7527117
Helicobacter pylori	Neutrophil-activating proteins (150-kDa)	GM3(NeuAc)	Monosialoglycosphingolipids	Human granulocytes	NeuAc(a2-3)Gal(b1-4)Glc(b1-1)Cer	Not Binding	9228091
Helicobacter pylori	Unknown	GM3(NeuAc)	Monosialoglycosphingolipids		NeuAc(a2-3)Gal(b1-4)Glc(b1-1)Cer	Binding	12628483
Rotavirus	VP8 (galectin)	Sialic acid(2-O-methyl-α-Neu5Ac (Neu5Ac2Me))	Monosaccharides			Binding	17306299
Clostridium botulinum	Botulinum neurotoxin (16S)	Mannose	Monosaccharides	Intestinal epithelial cells (T84)	Man	Not Binding	17156748
Shigella dysenteriae	Unknown	Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH)	Oligoglycosylceramides		Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	15973004
Sporothrix schenckii	Yeast cells and hyphae	Fibronectin	Glycoproteins	Extracellular matrix (ECM)		Binding	15351036
Escherichia coli	Verotoxin	Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH)	Oligoglycosylceramides		Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Binding	15973004
Helicobacter pylori	35S-labeled or 125I-labeled proteins	Gb4 (Globoside; Globotetraose; P antigen)	Oligoglycosylceramides	Human erythrocytes	GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer	Not Binding	9499377