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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Helicobacter pylori | Adhesins | Five-sugar monosialoganglioside | Monosialoglycosphingolipids | Human leukocytes, Human neutrophils | Binding | 10569742 | |
| Haemophilus influenzae | HMW1 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Haemophilus influenzae | HMW2 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Haemophilus influenzae | Hia | Oligosaccharides rich in sialic acid | Oligosaccharides | Human conjunctival cells (respiratory tract) | Binding | 12640357 | |
| Neisseria meningitidis | OpcA | Sialic acid-containing polysaccharides | Polysaccharides | Epithelial cells | Binding | 18076035 | |
| Clostridium tetani | Tetanus toxin (Hc fragment) | GT1b analog | Trisialoglycosphingolipids | Synapse | Binding | 18809496 | |
| Clostridium tetani | Unknown | GT1b analog | Trisialoglycosphingolipids | Synapse | Binding | 18809496 | |
| Influenza virus | Unknown | Neuraminic acid-containing sialoglycoproteins | Glycoproteins | Binding | 15973004 | ||
| Helicobacter pylori | Unknown | Heparan sulfate | Glycosaminoglycans | Binding | 16088272 | ||
| Bordetella pertussis | FHA (filamentous hemagglutinin) | Heparan sulfate | Glycosaminoglycans | Binding | 8574698 | ||
| Bordetella pertussis | FHA (filamentous hemagglutinin) | Heparan sulfate | Glycosaminoglycans | Binding | 8574698 | ||
| Helicobacter pylori | Unknown | Heparan sulfate | Glycosaminoglycans | Binding | 16088272 | ||
| Bordetella pertussis | FHA (filamentous hemagglutinin) | Heparan sulfate | Glycosaminoglycans | Binding | 8574698 | ||
| Helicobacter pylori | Unknown | Heparan sulfate | Glycosaminoglycans | Binding | 16088272 | ||
| Bordetella pertussis | FHA (filamentous hemagglutinin) | Heparan sulfate | Glycosaminoglycans | Binding | 8574698 | ||
| Borrelia burgdorferi | "DbpA, DbpB, Bgp" | Dermatan sulfate | Glycosaminoglycans | Binding | 16299269 | ||
| Helicobacter pylori | Unknown | Heparan sulfate | Glycosaminoglycans | Binding | 16088272 | ||
| Mycoplasma pneumoniae | Unknown | GSLs containing terminal Gal(3SO4)β1-residues | Glycosphingolipids | Binding | 15973004 | ||
| Rotavirus | VP8 (spike protein) | Sialic acid(2-O-methyl-α-Neu5Gc (Neu5Gc2Me)) | Monosaccharides | Binding | 17306299 | ||
| Haemophilus influenzae | HifE (Pili family) | GM1(NeuAc/NeuGc) | Monosialoglycosphingolipids | Binding | 12640357 | ||
| Haemophilus influenzae | HifE (Pili family) | GM1(NeuAc/NeuGc) | Monosialoglycosphingolipids | Binding | 12640357 | ||
| Escherichia coli | F1C | Lactosylceramide (t18:0-h16:0-h24:0) | Diosylceramides | Rabbit small intestine | Gal(b1-4)Glc(b1-1)Cer | Binding | 11877427 |
| Escherichia coli | PapG | alpha-D-galactopyranosyl-(1-4)-beta-D-galactopyranose | Disaccharides | Uroepithelial cells | Gal(a1-4)Gal | Binding | 2886993 |
| Escherichia coli | K1 | unnamed ligand | Disaccharides | Endothelial cells | GlcNAc(b1-4)GlcNAc | Binding | 16564136 |
| Clostridium botulinum | Progenitor toxin (type A) | Lactose | Disaccharides | Intestine-407 cells | Gal(b1-4)Glc | Binding | 15850798 |
