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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source ▲ | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Clostridium difficile | Toxin A | unnamed ligand | Oligosaccharides | Human colonic cells | GalNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 12507507 |
| Clostridium difficile | C-terminal domain of toxin A molecules | unnamed ligand | Oligosaccharides | Human colonic cells | GalNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 12507507 |
| Human immunodeficiency virus | gp120 | Galactosylceramide (Galactocerebroside) | Monoglycosylceramides | Human colonic epithelial cell lines (HT-29/HT-29-A7/HT-29-D4) | Gal(b1-1)Cer | Binding | 8464878 |
| Escherichia coli | P-pili | Surfactant-like particles (SLP) | Non-glycosylated Lipids | Human colonocytes and enterocytes | Binding | 10531281 | |
| Escherichia coli | PapD-PapG (class I) | Surfactant-like particles (SLP) | Non-glycosylated Lipids | Human colonocytes and enterocytes | Binding | 10531281 | |
| Haemophilus influenzae | Hia | Oligosaccharides rich in sialic acid | Oligosaccharides | Human conjunctival cells (respiratory tract) | Binding | 12640357 | |
| Haemophilus influenzae | Hia | unknown carbohydrate ligand | Saccharides | Human conjunctival cells (respiratory tract) | Binding | 10341176 | |
| Adenovirus | Fibre proteins | HSA glycoconjugates | Glycoproteins | Human corneal epithelial(HEC) cells | Binding | 15678425 | |
| Staphylococcus aureus | Unknown | MUC16 mucin | Glycoproteins | Human corneal-limbal epithelial(HCLE) cells | Binding | 17898272 | |
| Streptococcus pneumoniae | Adhesins | GlcNAc(b1-3)Gal sequence | Saccharides | Human endothelial cells | GlcNAc(b1-3)Gal | Binding | 6886624 |
| Haemophilus influenzae | HMW1 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Haemophilus influenzae | HMW2 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Neisseria gonorrhoeae | Unknown | Pentosan polysulfate (PP) | Polysaccharides | Human epithelial cells | Binding | 9420059 | |
| Neisseria gonorrhoeae | Unknown | Dextran sulfate | Polysaccharides | Human epithelial cells | Binding | 9420059 | |
| Neisseria gonorrhoeae | Unknown | NAC-heparin (non-anticoagulant heparin) | Glycosaminoglycans | Human epithelial cells | Binding | 9420059 | |
| Pseudomonas aeruginosa | Type 4-pili | Surface-localized glycoconjugates (non-sialylated GSL and glycoproteins) | Glycoconjugates | Human epithelial cells | Binding | 9224879 | |
| Legionella pneumophila | Adhesins | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Human epithelial cells (respiratory tract) | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 14687561 |
| Legionella pneumophila | Adhesins | unnamed ligand | Oligosaccharides | Human epithelial cells (respiratory tract) | Gal(b1-4)GlcNAc | Binding | 14687561 |
| Legionella pneumophila | Adhesins | GD1a | Disialoglycosphingolipids | Human epithelial cells (respiratory tract) | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Not Binding | 14687561 |
| Legionella pneumophila | Adhesins | GM3(NeuAc) | Monosialoglycosphingolipids | Human epithelial cells (respiratory tract) | NeuAc(a2-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 14687561 |
| Legionella pneumophila | Adhesins | GM1 | Monosialoglycosphingolipids | Human epithelial cells (respiratory tract) | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Not Binding | 14687561 |
| Legionella pneumophila | Adhesins | GM2(NeuAc) | Monosialoglycosphingolipids | Human epithelial cells (respiratory tract) | GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Not Binding | 14687561 |
| Legionella pneumophila | Adhesins | Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1) | Oligoglycosylceramides | Human epithelial cells (respiratory tract) | Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 14687561 |
| Haemophilus influenzae | HMW1 | unknown carbohydrate ligand | Saccharides | Human epithelial cells (respiratory tract) | Binding | 10341176 | |
| Haemophilus influenzae | HMW2 | unknown carbohydrate ligand | Saccharides | Human epithelial cells (respiratory tract) | Binding | 10341176 |
