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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule ▼ | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Rotavirus | VP8 (galectin) | Sialic acid(2-O-methyl-α-Neu5Ac (Neu5Ac2Me)) | Monosaccharides | Binding | 17306299 | ||
| Rotavirus | VP8 | Sialic acid | Monosaccharides | Epithelial cells of small intestine | Binding | 16511112 | |
| Rotavirus | VP8 | Sialic acid | Monosaccharides | Binding | 18540062 | ||
| Theiler's murine encephalomyelitis virus | VP2 amino acids on puff B | Sialic acid (α2,3) | Saccharides | Central nervous system | NeuAc(a2-3) | Binding | 16575521 |
| Foot-and-mouth disease virus | VP1 protein (RGD motif) | αvβ3 Integrin | Glycoproteins | BHK-21/LLC-MK2/HeLa/BK-LF | Binding | 7533862 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | αvβ3 Integrin (independent of expression of Heparan sulfate on cell-sulface) | Glycoproteins | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparin | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparin | Glycosaminoglycans | Extracellular matrix (ECM) | Not Binding | 9557639 | |
| Actinomyces naeslundii | Unknown | GD1b | Disialoglycosphingolipids | Human brain | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 2358461 |
| Clostridium tetani | Unknown | GD1b | Disialoglycosphingolipids | Brain membrane | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 6257717 |
| Norovirus | Unknown | Sialylated type 2 chain conjugates (S-type 2-HSA) | Glycoproteins | Human serum albumin | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD | Binding | 19054801 |
| Norovirus | Unknown | Sialyl Lewis x (SLex-HSA) | Glycoproteins | Human serum albumin | NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD | Binding | 19054801 |
| Influenza virus | Unknown | GM3(NeuAc) | Monosialoglycosphingolipids | Granulocytes | NeuAc(a2-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 8823909 |
| Influenza virus | Unknown | Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) | Monosialoglycosphingolipids | Granulocytes | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 8823909 |
| Sendai virus | Unknown | Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) | Monosialoglycosphingolipids | Granulocytes | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 8823909 |
| Actinomyces naeslundii | Unknown | GM1 | Monosialoglycosphingolipids | Human brain | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 2358461 |
| Helicobacter pylori | Unknown | unnamed ligand | Oligosaccharides | Stomach | NeuAc(a2-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Polyoma virus | Unknown | Sialylated oligosaccharides | Oligosaccharides | Erythrocytes | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 6316632 |
| Polyoma virus | Unknown | unnamed ligand | Oligosaccharides | Murine small plaque | NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc | Binding | 8574698 |
| Reovirus | Unknown | Sialic acid (α2,6) | Saccharides | Most organs including the central nervous system/heart/liver | NeuAc(a2-6) | Binding | 18216114 |
| Mycoplasma pneumoniae | Unknown | Sulfo-lactosylceramide (SM3) | Sulfoglycosphingolipids | Human colon adenocarcinoma cells (WiDr ) | HSO3(-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 2470753 |
