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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature ▲ | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Pseudomonas aeruginosa | PA-IL (51-kDa) | Galactose-alpha-1,3-galactose | Disaccharides | Gal(a1-3)Gal | Binding | 15049333 | |
| Pseudomonas aeruginosa | PA-IL (51-kDa) | Galactose-alpha-1,4-galactose | Disaccharides | Gal(a1-4)Gal | Binding | 15049333 | |
| Pseudomonas aeruginosa | PA-IIL | Blood group H antigen | Disaccharides | Fuc(a1-2)Gal | Binding | 16762477 | |
| Pseudomonas aeruginosa | PA-IL | Melibiose | Disaccharides | Gal(a1-6)Glc | Binding | 10967261 | |
| Ralstonia solanacearum | RSL (30-kDa proteins) | Blood group H antigen | Disaccharides | Fuc(a1-2)Gal | Binding | 16762477 | |
| Norovirus | Unknown | Blood group H antigen | Disaccharides | Fuc(a1-2)Gal | Binding | 18599458 | |
| Neisseria gonorrhoeae | N-methylphenyl-alanine pili | Glucosamine-galactose carbohydrate | Disaccharides | Binding | 12640357 | ||
| Streptococcus pneumoniae | PsaA (Lary family) | N-acetylhexosamine-galactose | Disaccharides | Binding | 12640357 | ||
| Norovirus | Unknown | Blood group H antigen | Disaccharides | Saliva | Fuc(a1-2)Gal | Not Binding | 18701592 |
| Streptococcus pneumoniae | Adhesins | unnamed ligand | Disaccharides | GalNAc(b1-4)Gal | Binding | 6886624 | |
| Pseudomonas aeruginosa | Pili | unnamed ligand | Disaccharides | GalNAc(b1-4)Gal | Binding | 8574698 | |
| Actinomyces naeslundii | Unknown | unnamed ligand | Disaccharides | GalNAc(b1-3)Gal | Binding | 12628483 | |
| Escherichia coli | SafS | α-sialyl-2-3-β-galactose | Disaccharides | Binding | 12640357 | ||
| Clostridium botulinum | Botulinum neurotoxin (type C) | GD1b | Disialoglycosphingolipids | Presynaptic neuronal cells | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 18242046 |
| Clostridium tetani | Tetanus toxin | GD1b | Disialoglycosphingolipids | Brain membrane | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 6257717 |
| Clostridium botulinum | BoNT/C (located within amino acid residues 1122-1290) | GD1b | Disialoglycosphingolipids | Presynaptic neuronal cells | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 18242046 |
| Influenza virus | Hemagglutinin (HA) | GD1a | Disialoglycosphingolipids | Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas) | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 11030743 |
| Actinomyces naeslundii | Unknown | GD1b | Disialoglycosphingolipids | Human brain | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 2358461 |
| Clostridium tetani | Unknown | GD1b | Disialoglycosphingolipids | Brain membrane | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 6257717 |
| Actinomyces naeslundii | Type-2 fimbrial lectins | GD1a | Disialoglycosphingolipids | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 3804448 | |
| Actinomyces naeslundii | Type-2 fimbrial lectins | GD1b | Disialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 3804448 | |
| Escherichia coli | K99 | GD1a(NeuGc) | Disialoglycosphingolipids | NeuGc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuGc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 7849044 | |
| Vibrio cholerae | Cholera toxin | GD1b | Disialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 8574698 | |
| Vibrio cholerae | Cholera toxin | GD1b | Disialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 3290106 | |
| Vibrio cholerae | Cholera toxin | GD1b | Disialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 7527546 |
