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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule ▼ | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Escherichia coli | Heat-labile enterotoxin | DSPG (Disialosyl paragloboside) | Disialoglycosphingolipids | NeuAc(a2-8)NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Escherichia coli | Heat-labile enterotoxin | Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) | Monosialoglycosphingolipids | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Escherichia coli | Heat-labile enterotoxin | GQ1b | Tetrasialoglycosphingolipids | NeuAc(a2-8)NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Escherichia coli | Heat-labile enterotoxin | Lactosylceramide (Lactocerebroside) | Diosylceramides | Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Escherichia coli | Heat-labile enterotoxin | Lc4Cer (Lactotetraosylceramide) | Oligoglycosylceramides | Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Helicobacter pylori | HPNAP (neutrophil-activating protein of H. pylori) | Acid glycosphingolipids | Acidic Glycosphingolipids | Human neutrophil granulocytes | Binding | 11087709 | |
| Helicobacter pylori | HP0721 | Sialyl Lewis x (SLex) antigen | Oligosaccharides | Gastric epithelial progenitors (GEPs) | NeuAc(a2-3)Gal(b1-4) | Binding | 16406776 |
| Newcastle disease virus | HN(hemagglutinin-neuraminidase) glycoproteins | Sialic acid | Monosaccharides | Binding | 17205603 | ||
| Haemophilus influenzae | HMW2 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Haemophilus influenzae | HMW2 | unknown carbohydrate ligand | Saccharides | Human epithelial cells (respiratory tract) | Binding | 10341176 | |
| Haemophilus influenzae | HMW1 | Oligosaccharides rich in sialic acid | Oligosaccharides | Human epithelial cells | Binding | 12640357 | |
| Haemophilus influenzae | HMW1 | unknown carbohydrate ligand | Saccharides | Human epithelial cells (respiratory tract) | Binding | 10341176 | |
| Human immunodeficiency virus | HIV surface glycoprotein gp120 | Galactosylceramide (Galactocerebroside) | Monoglycosylceramides | Neural cell lines | Gal(b1-1)Cer | Binding | 1857969 |
| Clostridium botulinum | HA | Lactose | Disaccharides | Intestinal epithelial cells (T84) | Gal(b1-4)Glc | Binding | 17156748 |
| Clostridium botulinum | HA | N-Acetylgalactosamine | Monosaccharides | Intestinal epithelial cells (T84) | GalNAc | Binding | 17156748 |
| Clostridium botulinum | HA | Galactose | Monosaccharides | Intestinal epithelial cells (T84) | Gal | Binding | 17156748 |
| Clostridium botulinum | HA | N-Acetylglucosamine | Monosaccharides | Intestinal epithelial cells (T84) | GlcNAc | Not Binding | 17156748 |
| Clostridium botulinum | HA | Mannose | Monosaccharides | Intestinal epithelial cells (T84) | Man | Not Binding | 17156748 |
| Clostridium botulinum | HA | Glucose | Monosaccharides | Intestinal epithelial cells (T84) | Glc | Not Binding | 17156748 |
| Clostridium botulinum | HA | Fucose | Monosaccharides | Intestinal epithelial cells (T84) | Fuc | Not Binding | 17156748 |
| Lassa virus | Glycoprotein (GP) | O-mannosyl glycans on alpha-dystroglycan (DG) | O-glycans | Fibroblasts, Epithelial cells, Endothelial cells, Hepatocytes | Binding | 17360738 | |
| Lymphocytic choriomeningitis virus | Glycoprotein (GP) | O-mannosyl glycans on alpha-dystroglycan (DG) | O-glycans | Fibroblasts, Epithelial cells, Endothelial cells, Hepatocytes | Binding | 17360738 | |
| New world arenavirus | Glycoprotein (GP) | O-mannosyl glycans on alpha-dystroglycan (DG) | O-glycans | Binding | 17360738 | ||
| Entamoeba histolytica | Gal/GalNAc Lectins (260-kDa) | N-Acetylgalactosamine | Monosaccharides | c-Met on hepatocytes | GalNAc | Binding | 9878032 |
| Entamoeba histolytica | Gal/GalNAc Lectins (260-kDa) | Galactose | Monosaccharides | c-Met on hepatocytes | Gal | Binding | 9878032 |
