Interleukin-6 signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
JAK1, JAK2, (TYK2)IL6ST:JAK1, JAK2, (TYK2)IL6STsIL6RIL6:IL6R-2IL6IL6:sIL6R:sgp130sgp130IL6:IL6RIL6RIL6:sIL6R:IL6RB:JAKsIL6:IL6RA:IL6RB:JAKsIL6 receptor trimer:JAKsIL6 receptor hexamer:JAKsIL6 receptor hexamer:Activated JAKsATPADPTyrosine phosphorylated IL6 receptor hexamer:Activated JAKsSTAT1, STAT3Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3p-Y701-STAT1, p-Y705-STAT3p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3STAT1/3 homo and heterodimersSHP2Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3SOCS3Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBLCBLIL6R inhibitorsIL6R:IL6R inhibitors
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025