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Standards Ontologies Notations
Guidelines
MIRAGE
Interleukin-6 receptor subunit alpha

Summary
UniProt ID
P08887
Gene Symbol
  • IL6R
Gene ID
3570
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011451
GlyGen
P08887
PubChem
P08887
The O-GlcNAc Database
P08887
Re-Glyco
P08887
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin domain
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 8 entries
GO Term
extracellular region
extracellular space
plasma membrane
receptor complex
external side of plasma membrane
apical plasma membrane
interleukin-6 receptor complex
ciliary neurotrophic factor receptor complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Site Annotations
Displaying 1 entry
Position Description
245 Not glycosylated
Annotation information from UniProt.
Sequence
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 12 in total
Position Description PubMed ID GlyTouCan ID Source
55 N-linked (GlcNAc...) asparagine
93 N-linked (GlcNAc...) asparagine
139
197
221 N-linked (GlcNAc...) asparagine
245 N-linked (GlcNAc...) asparagine
320
329
335
350 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 6 entries
Pathway Name Organism
Interleukin-4 and Interleukin-13 signaling Homo sapiens
Interleukin-6 signaling Homo sapiens
MAPK1 (ERK2) activation Homo sapiens
MAPK3 (ERK1) activation Homo sapiens
Potential therapeutics for SARS Homo sapiens
Transcriptional regulation of granulopoiesis Homo sapiens
Disease
Displaying all 5 entries
DO ID Disease Name Source
DOID:0080545 hyper IgE syndrome
DOID:10534 stomach cancer
DOID:10652 Alzheimer's disease
DOID:12858 Huntington's disease
DOID:9970 obesity
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025