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Interleukin-6 receptor subunit alpha

Summary

UniProt ID

P08887

Gene Symbol

IL6R

Organism

Homo sapiens (human)

External Links

GlycoProtDB: GPDB0011451
GlyGen: P08887
PubChem: P08887
The O-GlcNAc Database: P08887

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **11 - 20** of 27 in total

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GO Term
response to cytokine
positive regulation of osteoblast differentiation
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
acute-phase response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
extrinsic apoptotic signaling pathway

Displaying **all 8** entries
GO Term
extracellular region
extracellular space
plasma membrane
receptor complex
apical plasma membrane
interleukin-6 receptor complex
external side of plasma membrane
ciliary neurotrophic factor receptor complex

Displaying **all 8** entries
GO Term
cytokine receptor activity
enzyme binding
protein homodimerization activity
interleukin-6 receptor activity
interleukin-11 receptor activity
interleukin-11 binding
interleukin-6 binding
ciliary neurotrophic factor binding

Site Annotations

Displaying 1 entry
Position	Description
245	Not glycosylated

Annotation information from UniProt.

Sequence

MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
55	N-linked (GlcNAc...) asparagine	10066782 28060820		UniProt GlyGen
93	N-linked (GlcNAc...) asparagine	10066782 28060820	G83460ZZ	GlycoProtDB UniProt GlyGen
197			G49108TO	GlyGen The O-GlcNAc Database
221	N-linked (GlcNAc...) asparagine	10066782 28060820		UniProt GlyGen
245	N-linked (GlcNAc...) asparagine	28060820		UniProt GlyGen
320			G57321FI	GlyGen
329			G43417UB	GlyGen
335			G53434XO	GlyGen
350	N-linked (GlcNAc...) asparagine	28060820		UniProt GlyGen
352	O-linked (GlcNAc) threonine	28060820		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Interleukin-4 and Interleukin-13 signaling	Homo sapiens
Interleukin-6 signaling	Homo sapiens
MAPK1 (ERK2) activation	Homo sapiens
MAPK3 (ERK1) activation	Homo sapiens
Potential therapeutics for SARS	Homo sapiens
Transcriptional regulation of granulopoiesis	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements