Signaling by NODAL

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
SMAD4p-2S-SMAD2,3:SMAD4p-2S-SMAD2,3p-2S-SMAD2,3:SMAD4SMAD2,3:SMAD4:FOXH1:Activin Response ElementActivin Response ElementFOXH1NODAL(27-347) dimerNODAL dimerNODAL ReceptorNODAL Ligand:NODAL ReceptorNODAL dimer, NODAL:GDF1NODAL:ACVR1B:ACVR2A,B:EGF-CFCNODAL:p-ACVR1B:ACVR2:EGF-CFCATPADPNODAL:ACVR1C:ACVR2B:EGF-CFCNODAL:p-ACVR1C:ACVR2B:EGF-CFCSMAD2,3SMAD2,3:SMAD4:FOXO3:FoxO3a-binding ElementFoxO3a-binding ElementFOXO3
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 17 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O00292 Left-right determination factor 2
  • EBAF
  • LEFTA
  • LEFTY2
  • LEFTYA
  • TGFB4
view
O43524 Forkhead box protein O3
  • FKHRL1
  • FOXO3
  • FOXO3A
view
O75593 Forkhead box protein H1
  • FAST1
  • FAST2
  • FOXH1
view
O75610 Left-right determination factor 1
  • LEFTB
  • LEFTY1
  • LEFTYB
view
O95813 Cerberus
  • CER1
  • DAND4
view
P09958 Furin
  • FUR
  • FURIN
  • PACE
  • PCSK3
view
P0CG37 Cryptic protein
  • CFC1
view
P13385 Protein Cripto
  • CRIPTO
  • CRIPTO-1
  • TDGF1
view
P27037 Activin receptor type-2A
  • ACVR2
  • ACVR2A
view
P27539 Embryonic growth/differentiation factor 1
  • GDF1
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025