Interleukin-7 signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-STAT5p-STAT5 dimerp-STAT5 dimerJAK3IL2RG:JAK3IL2RGIL7PPBSFSFIL7R:JAK1IL7:IL7R:JAK1IL7:IL7R:JAK1:IL2RG:JAK3ATPIL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3IL7:IL7R:JAK1:IL2RG:p-JAK3ADPIL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5BSTAT5IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5BCISH gene, SOCS1 gene, SOCS2 gene:p-STAT5 dimerCISH gene, SOCS1 gene, SOCS2 geneCISH,SOCS1,SOCS2BRWD1 genep-STAT5 dimer:BRWD1 geneImmunoglobulin kappa locusRAG1:RAG2 recombinase:Immunoglobulin kappa locusRAG1:RAG2 recombinaseCRLF2:IL7RIL7R:TSLP:CRLF2TSLPSTAT3IL7R:TSLP:CRLF2:STAT3IL7R:TSLP:CRLF2:p-STAT3p-STAT3IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunitsPI3K regulatory subunitsIRS1,2IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2BRWD1BRWD1:AcK(9,14,18,79)-p(S10,T11)-histone H3AcK(9,14,18,79)-p(S10,T11)-histone H3JAK3:JAK3 inhibitorsJAK3 inhibitorsJAK1IL7RBRG1WDR9:BRG1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025