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Hepatocyte growth factor

Summary

UniProt ID

P14210

Gene Symbol

HGF
HPTA

Organism

Homo sapiens (human)

External Links

GlyConnect

GlyGen

P14210

PubChem

P14210

RaftProt

P14210

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Kringle
Non-syndromic deafness
Pyrrolidone carboxylic acid
Reference proteome
Repeat
Serine protease homolog
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 28 in total

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GO Term
cell morphogenesis
epithelial to mesenchymal transition
positive regulation of protein phosphorylation
negative regulation of interleukin-6 production
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
regulation of p38MAPK cascade
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of DNA biosynthetic process

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
membrane
platelet alpha granule lumen

Displaying **all 4** entries
GO Term
signaling receptor binding
growth factor activity
identical protein binding
chemoattractant activity

Annotation information from UniProt.

Sequence

MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
294			G57789QC G64394MX G60542VK G93656SY G01543ZX G11629QQ G74239ZQ G52126RR G52527GH G89664KV G17689DH G22310AV G48414YA G77252PU	UniProt GlyGen GlyConnect
402			G57789QC G64394MX G60542VK G93656SY G01543ZX G11629QQ G74239ZQ G52126RR G52527GH G89664KV G17689DH G22310AV G48414YA G77252PU	UniProt GlyGen GlyConnect
476	O-linked (GalNAc...) threonine	1482348	G45637XA G81006GJ	UniProt GlyGen GlyConnect
566			G57789QC G64394MX G01543ZX G11629QQ G74239ZQ G86880BF G52126RR G52527GH G89664KV G40834TG G17689DH G22310AV G45395BF G08918WF G48414YA G77252PU G27126ED G04657PL G27058EU G41071NU G42124LM G90659AW	UniProt GlyGen GlyConnect
653			G57789QC G64394MX G01543ZX G11629QQ G74239ZQ G52126RR G52527GH G17689DH G22310AV G48414YA G77252PU G46691LC G27058EU G83460ZZ G41071NU G80920RR G42124LM G90659AW G62765YT G41247ZX	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 18 in total

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Pathway Name	Organism
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
Drug-mediated inhibition of MET activation	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens
Interleukin-7 signaling	Homo sapiens
MET Receptor Activation	Homo sapiens
MET activates PI3K/AKT signaling	Homo sapiens
MET activates PTK2 signaling	Homo sapiens
MET activates PTPN11	Homo sapiens
MET activates RAP1 and RAC1	Homo sapiens
MET activates RAS signaling	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements