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MIRAGE
Binding and entry of HIV virion

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Mature HIV virionVirion with CD4 bound to gp120CD4Virion with exposed coreceptor binding sitesVirion with CD4:gp120 bound to CCR5/CXCR4CCR5, CXCR4Virion with gp41 exposedVirion with fusogenically activated gp41Virion with gp41 fusion peptide in insertion complexVirion with gp41 forming hairpin structureCD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4Viral core surrounded by Matrix layer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025