Activation of ATR in response to replication stress

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
CDC25Ap-S124-CDC25AATPADPChk1phospho-Chk1Persistent single-stranded DNARPA-ssDNA complexRPA heterotrimerATR:ATRIP:RPA:ssDNA signaling complexATR:ATRIPRad17-RFC complex bound to DNARAD17:RFC9-1-1 complexRad9-Hus1-Rad1 bound to DNACLSPNclaspin bound to DNA replication forkCDK:DDK:MCM10:active pre-replicative complex:CDC45Activated claspin bound to DNA replication forkp-S216-CDC25CCDC25C
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025