Activation of ATR in response to replication stress

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
CDC25AADPp-S124-CDC25AATPChk1phospho-Chk1RPA heterotrimerRPA-ssDNA complexPersistent single-stranded DNAATR:ATRIPATR:ATRIP:RPA:ssDNA signaling complexRAD17:RFCRad17-RFC complex bound to DNARad9-Hus1-Rad1 bound to DNA9-1-1 complexCDK:DDK:MCM10:active pre-replicative complex:CDC45claspin bound to DNA replication forkCLSPNActivated claspin bound to DNA replication forkp-S216-CDC25CCDC25C
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: March 31, 2025