Senescence-Associated Secretory Phenotype (SASP)

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ATPPhospho-Ribosomal protein S6 kinaseADPRibosomal protein S6 kinaseIL6 genep-T235,S321-CEBPB:NF-kB:IL6 genep-T235,S321-CEBPB homodimerNF-kB complexIL6CCNA:p-T160-CDK2Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complexCdh1:phospho-APC/C complexCyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complexGLP:G9aEHMT1:EHMT2:Cdh1:p-APC/CUb-EHMT1:Ub-EHMT2:Cdh1:p-APC/CUbSAMSAHIL6 gene:NucleosomeIL6 gene:Nucleosome-H3K9Me2IL8 gene:NucleosomeIL8 gene:Nucleosome-H3K9Me2LAPp-T235-CEBPBp-T235, S321-CEBPBCEBPB genep-T235,S321-CEBPB:NF-kB:IL8 GeneIL8 geneIL8CDKN2B genep-T235,S321-CEBPB:CDKN2B GeneMTS2IGFBP7 geneAP-1:IGFBP7 genep-2S-cJUN:p-2S,2T-cFOSPSFp-2S-JUN:p-2S,2T-FOS:IL1A geneIL1A geneIL1AINK4CDK4,CDK6:INK4CDK4,CDK6
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 44 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O60814 Histone H2B type 1-K
  • H2BC12
  • H2BFT
  • HIRIP1
  • HIST1H2BK
view
O95231 Homeobox protein VENTX
  • HPX42B
  • VENTX
  • VENTX2
view
P01100 Protein c-Fos
  • FOS
  • G0S7
view
P01583 Interleukin-1 alpha
  • IL1A
  • IL1F1
view
P04908 Histone H2A type 1-B/E
  • H2AC4
  • H2AC8
  • H2AFA
  • H2AFM
  • HIST1H2AB
  • HIST1H2AE
view
P05231 Interleukin-6
  • IFNB2
  • IL6
view
P05412 Transcription factor Jun
  • JUN
view
P06899 Histone H2B type 1-J
  • H2BC11
  • H2BFR
  • HIST1H2BJ
view
P16104 Histone H2AX
  • H2AFX
  • H2AX
view
P17676 CCAAT/enhancer-binding protein beta
  • CEBPB
  • TCF5
view
a simple tooltip

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.2.1

Last updated: April 7, 2025