G alpha (12/13) signalling events

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
G-protein G12/G13 (inactive)Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive).Ligand:GPCR complexes that activate G12/13Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active).GTPGDPG-protein alpha (12/13):GTPLigands of GPCRs that activate G12/13GPCRs that activate G12/13G-protein beta-gamma complexG-protein alpha (13):GTPG13-activated p115-RhoGEFARHGEF1RHOA:GDPRHOA:GTPRHOA/B/C:GTPRhoA,B,C:GDPROCK1,ROCK2Activated ROCK:RhoA/B/C:GTPLARGG-protein alpha (12/13):LARGPLXNB1G-protein alpha (12/13):LARG:Plexin B1G-protein alpha (12/13):GDPG-protein alpha (12):GTPG alpha (12):BTKBTKG alpha (12):Active BTKBTK_HUMANROCK1,ROCK2:ROCKiROCKi
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025