G alpha (12/13) signalling events

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ROCKiROCK1,ROCK2:ROCKiROCK1,ROCK2Ligand:GPCR complexes that activate G12/13Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive).G-protein G12/G13 (inactive)GDPGTPLigand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active).G-protein beta-gamma complexG-protein alpha (12/13):GTPLigands of GPCRs that activate G12/13GPCRs that activate G12/13ARHGEF1G13-activated p115-RhoGEFG-protein alpha (13):GTPRHOA:GDPRHOA:GTPRhoA,B,C:GDPRHOA/B/C:GTPActivated ROCK:RhoA/B/C:GTPG-protein alpha (12/13):LARGLARGG-protein alpha (12/13):LARG:Plexin B1PLXNB1G-protein alpha (12/13):GDPBTKG alpha (12):BTKG-protein alpha (12):GTPG alpha (12):Active BTKBTK_HUMAN
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 41 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
A8MVX0 Rho guanine nucleotide exchange factor 33
  • ARHGEF33
view
O14827 Ras-specific guanine nucleotide-releasing factor 2
  • GRF2
  • RASGRF2
view
O15085 Rho guanine nucleotide exchange factor 11
  • ARHGEF11
  • KIAA0380
view
O43157 Plexin-B1
  • KIAA0407
  • PLXN5
  • PLXNB1
  • SEP
view
O60229 Kalirin
  • DUET
  • DUO
  • HAPIP
  • KALRN
  • TRAD
view
O75116 Rho-associated protein kinase 2
  • KIAA0619
  • ROCK2
view
O75962 Triple functional domain protein
  • TRIO
view
P08134 Rho-related GTP-binding protein RhoC
  • ARH9
  • ARHC
  • RHOC
view
P10911 Proto-oncogene DBL
  • DBL
  • MCF2
view
P15498 Proto-oncogene vav
  • VAV
  • VAV1
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025