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MIRAGE
G alpha (s) signalling events

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Heterotrimeric G-protein Gs (inactive)Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive)Ligand:GPCR complexes that activate GsGTPGDPGPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active)Gs:GTPLigands of GPCRs that activate GsGPCRs that activate GsG-protein beta-gamma complexcAMPAMPH2OPDE4APDE4A:PDE4A inhibitorsPDE4A inhibitorsPDE3APDE3A inhibitors:PDE3APDE3A inhibitorsG alpha (s):GDPPiADRB2:Catecholamine:GRKpS-ADRB2:Catecholamine:GRKADPATPpS-ADRB2:CatecholaminepS-ADRB2:Catecholamine:ARRB1,ARRB2ARRBG alpha (s):GTP:SRCSRCG alpha (s):GTP:p-Y419-SRCp-Y419-SRCADRB2:ADR,NAdGRK2, GRK3, GRK5, GRK6Adenylate cyclase (Mg2+ cofactor)Gs-activated adenylate cyclasePPi
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025