RAF activation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
YWHAB dimerinactive RAFs:YWHAB dimerinactive RAFsdephosphorylated inactive RAFS:YWHAB dimerH2OPidephosphorylated inactive RAFsp21 RAS:GTPp21 RAS:GTP:'activator' RAF:YWHAB dimer'activator' RAF:YWHAB dimerdephosphorylated "receiver" RAF/KSR1p21 RAS:GTP:homo/heterodimerized RAF complexATPADPp-S311,S406 KSR1:MARK3KSR1:MARK3p-S311,S406 KSR1:MARK3:YWHAB dimerp-S311 KSR1:MARK3:YWHAB dimerp-S311 KSR1:MARK3p21 RAS:GTP:activated RAF homo/heterodimer complexesRAF dimer inhibitorsp21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025