RNA Polymerase II Pre-transcription Events

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
pol II transcription complexGTF2BTFIIDTFIIAtemplate DNA with first transcript dinucleotide, opened to +8 positionTFIIERNA Polymerase II (unphosphorylated):TFIIF complexTFIIHpol II transcription complex containing 4-9 nucleotide long transcripttemplate DNA:4-9 nucleotide transcript hybridPol II Promoter Escape ComplexDNA containing Pol II promoter with transcript with 2 or 3 nucleotidesSUPT4H1DSIF complexSUPT5HEloBElongin B:C complexEloCT160FACT complexSUPT16HNELFBNELF complexNELFCDRDBPNELFACDK9P-TEFb complexCCNT1,CCNT2,CCNKElongin AElongin ComplexPaused processive elongation complexProcessive elongation complexArrested processive elongation complexDSIF:NELF:early elongation complexAborted early elongation complexAborted elongation complex after arrestp-POLR2TCEA1NTPPAF1Cdamaged DNA substrate:nascent mRNA hybridMLLT3EAF1AFF4CTDP1MLLT1ELLIWS1TFIIFSUPT6HEAF2pol II open pre-initiation complexpol II closed pre-initiation complex
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025