Complex I biogenesis

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
NUBPLNUBPL:4Fe-4S4Fe-4SNDUF subunitsNDUF:4Fe-4S subunitsNDUFV1:4Fe-4S:FMNNDUFV1NDUFV2:4Fe-4SFMNNDUFV2NDUFAF7:NDUFS2:2x4Fe-4SIP subcomplexNDUFA9:FADNDUFS7:4Fe-4SNDUFS8:2x4Fe-4SNDUFS3TIMMDC1Intermediate 1NDUFAF3NDUFAF4HP subcomplexIntermediate 2MT-ND1315kDa subcomplexNDUFAF5NDUFAF6COA1:MT-ND2370 kDa subcomplexTMEM186:MT-ND3MT-ND6MCIA complexNDUFB6550kDa complexMT-ND4 mRNAMT-ND4815kDa complexMT-ND5NDUFA12FP subcomplexNDUFV3NDUFAF2NDUFS1:2x4Fe-4SNDUFS6NDUFS4980kDa complexNDUFS5NDUFAF7Complex I
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025